期刊
EXCLI JOURNAL
卷 21, 期 -, 页码 317-334出版社
EXCLI JOURNAL MANAGING OFFICE
DOI: 10.17179/excli2021-4382
关键词
Diabetes mellitus; insulin resistance; stress; immune system; insulin signal transduction
类别
There is strong evidence supporting the relationship between stress and insulin resistance. Stress can impair glucose homeostasis through multiple molecular pathways, potentially leading to the development of diabetes.
To date, there is ample evidence to support the strong relationship between stress and insulin resistance. While diabetes mellitus acts as a potent stress inducer, stress may be an upstream event for insulin resistance as well. It is widely recognized that diabetes mellitus is more prevalent among people who have a stressful lifestyle; however, the underlying mechanisms are not well understood. In the current study, we surveyed the scientific literature for possible interactions between stress and insulin resistance and found that stress can impair glucose homeostasis, working through at least six molecular pathways.
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