期刊
ACS APPLIED BIO MATERIALS
卷 5, 期 2, 页码 771-778出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.1c01161
关键词
electrospinning; on-demand release; reduced graphene oxide; mucoadhesive; buccal mucosa
资金
- Centre National de la Recherche Scientifique (CNRS)
- University of Lille
- Hauts-de-France region
- CPER Photonics for Society
- French Renatech network
- i-SITE foundation of the University of Lille
- European Union's Horizon 2020 Research and Innovation Staff Exchange (RISE) Marie Sklodowska-Curie Actions [690836]
Electrospun fiber mats loaded with therapeutics are being used as a versatile tool in the biomedical field, with stimuli-responsive fiber mats offering timely and controlled drug delivery, particularly for on-demand hormone release like insulin. Research has shown that modified poly(acrylic acid) fiber mats can effectively deliver insulin through buccal and corneal routes.
Electrospun fiber mats loaded with therapeutics have gained considerable attention as a versatile tool in the biomedical field. While these bandages are largely based on fast-dissolving polymers to release the cargo, stimuli-responsive fiber mats have the advantages of providing a timely and spatially controlled drug delivery platform, which can be refilled and reused several times. These benefits make electrospun fiber patches original platforms for painless and convenient on-demand hormone release. Because of the high need of more convenient and non-invasive methods for delivering insulin, a hormone that is currently used to treat hundred million people with diabetes worldwide, we have investigated the tremendous potential of reduced graphene oxide modified poly(acrylic acid) based fiber mats as an original platform for buccal and corneal insulin delivery on-demand. The PAA@rGO hydrogel-like fibers rendered water-insoluble by incorporating beta-cyclodextrin, followed by thermal cross-linking, which showed adequate tensile strength along with high adsorption capacity of insulin at pH 7 and good recyclability. The fiber mats maintained good fibrous morphology and high loading efficiency even after five loading-release cycles. The mucoadhesive nature of the fibers allowed their application for insulin delivery via the eye cornea and the buccal mouth lining, as evidenced in ex vivo studies. Insulin loaded PAA@rGO hydrogel-like fibers showed an insulin flux via buccal lining of pigs of 16.6 +/- 2.9 mu g cm(-2) h(-1) and 24.3 +/- 3.1 mu g cm(-2) h(-1) for porcine cornea. Testing on healthy adult volunteers confirmed the excellent, mucoadhesive nature of the bandage, with three out of six volunteers feeling completely comfortable (note 8.3) while wearing the patches in the buccal cavity.
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