期刊
JOURNAL OF CLINICAL MEDICINE
卷 5, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/jcm5040041
关键词
signaling transduction pathways; EMT; TGF-; SHH; WNT; modeling
资金
- NIGMS-DMS joint mathematical biology program [DMS-1545771, DMS-1462049]
- PA Department of Health [SAP 4100062224]
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [1462049] Funding Source: National Science Foundation
Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing, and cancer development. It involves cooperation of signaling pathways, such as transformation growth factor- (TGF-), Sonic Hedgehog (SHH), and WNT pathways. These signaling pathways crosstalk to each other and converge to key transcription factors (e.g., SNAIL1) to initialize and maintain the process of EMT. The functional roles of multi-signaling pathway crosstalks in EMT are sophisticated and, thus, remain to be explored. In this review, we focused on three major signal transduction pathways that promote or regulate EMT in carcinoma. We discussed the network structures, and provided a brief overview of the current therapy strategies and drug development targeted to these three signal transduction pathways. Finally, we highlighted systems biology approaches that can accelerate the process of deconstructing complex networks and drug discovery.
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