期刊
ACS ORGANIC & INORGANIC AU
卷 2, 期 1, 页码 34-43出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsorginorgau.1c00025
关键词
Asymmetric Catalysis; Ammonium Salt Catalysis; Kinetic Resolution; DFT Calculations
资金
- Austrian Science Funds (FWF) [P31784]
- National Science Foundation [CHE210031]
- XSEDE Science Gateways Program
- [ACI-1548562]
- Austrian Science Fund (FWF) [P31784] Funding Source: Austrian Science Fund (FWF)
The enantioselective synthesis of novel differently functionalized alpha-halogenated alpha-aryl-beta 2,2-amino acid derivatives was achieved using an ammonium-salt-catalyzed asymmetric alpha-halogenation of isoxazolidin-5-ones. The use of Maruoka's spirocyclic binaphthyl-based ammonium salts and detailed mechanistic studies revealed the key features for the catalyst-substrate interactions.
The enantioselective synthesis of a broad variety of novel differently functionalized alpha-halogenated alpha-aryl-beta 2,2-amino acid derivatives by means of an ammonium-salt-catalyzed asymmetric alpha-halogenation of isoxazolidin-5-ones was accomplished. Key to success to obtain high levels of enantioselectivities was the use of Maruoka's spirocyclic binaphthyl-based ammonium salts, and detailed accompanying mechanistic studies using density functional theory methods revealed the key features for the catalyst-substrate interactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据