期刊
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
卷 25, 期 1, 页码 14-26出版社
MASHHAD UNIV MED SCIENCES
DOI: 10.22038/IJBMS.2022.60380.13381
关键词
Baicalein; Baicalin; Cancer; Inflammatory diseases; Mitochondrial functions
资金
- University industrial research innovation fund of science and technology development center of the Ministry of education of China [2020ITA05022]
- Natural Science Foundation of Hubei Province [2021CFB316]
- Preliminary support project of Hubei Social Science Foundation [21ZD137]
- Hundreds of Schools Unite with Hundreds of Counties-University Serving Rural Revitalization Science and Technology Support Action Plan [BXLBX0847]
Baicalin and baicalein are flavonoids with multiple therapeutic properties, including antibacterial, antiviral, anticancer, anticonvulsant, anti-oxidant, hepatoprotective, and neuroprotective effects. These properties are attributed to their ability to scavenge reactive oxygen species (ROS) and interact with various signaling molecules associated with different cellular processes. This review summarizes the molecular mechanisms underlying the chemopreventive and chemotherapeutic applications of baicalin and baicalein, with a particular focus on their effects on mitochondrial dynamics and functions.
The flavonoids, baicalin, and its aglycone baicalein possess multi-fold therapeutic properties and are mainly found in the roots of Oroxylum indicum (L.) Kurz and Scutellaria baicalensis Georgi. These flavonoids have been reported to possess various pharmacological properties, including antibacterial, antiviral, anticancer, anticonvulsant, anti-oxidant, hepatoprotective, and neuroprotective effects. The pharmacological properties of baicalin and baicalein are due to their abilities to scavenge reactive oxygen species (ROS) and interaction with various signaling molecules associated with apoptosis, inflammation, autophagy, cell cycle, mitochondrial dynamics, and cytoprotection. In this review, we summarized the molecular mechanisms underlying the chemopreventive and chemotherapeutic applications of baicalin and baicalein in the treatment of cancer and inflammatory diseases. In addition, the preventive effects of baicalin and baicalein on mitochondrial dynamics and functions were highlighted with a particular emphasis on their anti-oxidative and cytoprotective properties. The current review highlights could be useful for future prospective studies to further improve the pharmacological applications of baicalein and baicalin. These studies should define the threshold for optimal drug exposure, dose optimization and focus on therapeutic drug monitoring, objective disease markers, and baicalin/baicalein drug levels.
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