期刊
AMERICAN JOURNAL OF CANCER RESEARCH
卷 12, 期 1, 页码 327-+出版社
E-CENTURY PUBLISHING CORP
关键词
Prostate cancer; integrated stress response; autophagy; mitochondria; ATF4; eIF2 alpha; STAMP2
类别
STAMP2 suppresses autophagy through modulation of the integrated stress response axis and regulates mitochondrial respiration, both of which have significant metabolic effects and support PCa growth.
Six Transmembrane Protein of Prostate 2 (STAMP2) is critical for prostate cancer (PCa) growth. We previously showed that STAMP2 regulates the expression of stress induced transcription factor ATF4, which is implicated in starvation-induced autophagy. We therefore investigated whether STAMP2 is involved in the regulation of autophagy in PCa cells. Here we show that STAMP2 suppresses autophagy in PCa cells through modulation of the integrated stress response axis. We also find that STAMP2 regulates mitochondrial respiration. These findings suggest that STAMP2 has significant metabolic effects through mitochondrial function and autophagy, both of which support PCa growth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据