Intramolecular Hydrogen-Bond Activation: Strategies, Benefits, and Influence in Catalysis

The activation of molecules through intramolecular hydrogen-bond formation to promote chemical reactions appears as a suitable strategy in organic synthesis, especially for the preparation of chiral compounds under metal and organocatalytic conditions. The use of this interaction has enabled reactivity enhancement of reagents, as well as stabilization of the chemical species and enantiocontrol of the processes.

Automated summary

The activation of molecules through intramolecular hydrogen-bond formation is an effective strategy in organic synthesis for enhancing reactivity, stabilizing chemical species, and controlling enantioselectivity.