期刊
GENOMICS PROTEOMICS & BIOINFORMATICS
卷 14, 期 5, 页码 280-288出版社
ELSEVIER
DOI: 10.1016/j.gpb.2016.03.007
关键词
-
As a leading cause of cancer deaths worldwide, lung cancer is a collection of diseases with diverse etiologies winch can be broadly classified into small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Lung cancer is characterized by genomic and epigenomic alterations; however, mechanisms underlying lung tumorigenesis remain to be elucidated. Long non coding RNAs (lncRNAs) are a group of non-coding RNAs that consist of >200 nucleotides but possess low or no protein-coding potential. Accumulating evidence indicates that abnormal expression of lncRNAs is associated with tumorigenesis of various cancers, including lung cancer, through multiple biological mechanisms involving epigenetic, transcriptional, and post-transcriptional alterations. In this review, we highlight the expression and roles of lncRNAs in NSCLC and discuss their potential clinical applications as diagnostic or prognostic biomarkers, as well as therapeutic targets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据