期刊
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
卷 5, 期 1, 页码 15-26出版社
WILEY
DOI: 10.1002/ame2.12207
关键词
Alzheimer's disease; animal model; cognitive deficits; memory loss; stem cell therapy
资金
- National Natural Science Foundation of China [81941012]
- CAMS initiative for Innovative Medicine of China [2021--I2 M--1--034]
- National Key Research and Development Project [2017YFA0105200]
Alzheimer's disease is a neurodegenerative disorder that can be improved by stem cell transplantation, which has the potential to ameliorate cognitive deficits. Stem cell transplantation has inherent advantages in improving cognitive impairment and memory dysfunction, but certain limitations need to be overcome.
Alzheimer's disease (AD) is a neurodegenerative disorder. The pathology of AD is characterized by extracellular amyloid beta (A beta) plaques, neurofibrillary tangles composed of hyperphosphorylated tau, neuronal death, synapse loss, and brain atrophy. Many therapies have been tested to improve or at least effectively modify the course of AD. Meaningful data indicate that the transplantation of stem cells can alleviate neuropathology and significantly ameliorate cognitive deficits in animal models with Alzheimer's disease. Transplanted stem cells have shown their inherent advantages in improving cognitive impairment and memory dysfunction, although certain weaknesses or limitations need to be overcome. This review recapitulates rodent models for AD, the therapeutic efficacy of stem cells, influencing factors, and the underlying mechanisms behind these changes. Stem cell therapy provides perspective and challenges for its clinical application in the future.
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