3.8 Review

The Road Toward Transformative Treatments for Food Allergy

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Review Allergy

Mechanisms of oral immunotherapy

Suzanne M. Barshow et al.

Summary: Food allergy is a significant global health concern affecting up to 10% of the population in developed nations, with oral immunotherapy (OIT) showing promise as a treatment. While some patients achieve sustained unresponsiveness with OIT, this state is immunologically distinct from natural tolerance.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

Article Allergy

Interrupting reactivation of immunologic memory diverts the allergic response and prevents anaphylaxis

Kelly Bruton et al.

Summary: The study found that blocking IL-4/IL-13 signaling can abort IgE production and skew the cytokine response away from a type 2 signature. T(H)2A cells identified by single-cell RNA sequencing expanded with peanut stimulation and maintained their pathogenic phenotype.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Review Allergy

Integrating oral immunotherapy into clinical practice

Stephanie A. Leonard et al.

Summary: The approval of new food allergy treatments in 2020 will require adjustment in allergy offices and open communication with patients and their families. Oral immunotherapy may not be suitable for every patient, and proper selection and management of candidates is crucial.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Immunology

Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy

Yoshihiro Takasato et al.

Summary: Oral immunotherapy (OIT) is an effective approach to controlling food allergy, but the detailed mechanisms are still unknown. Research has shown that desensitization modulates the activation of mast cells, leading to enhanced expansion of regulatory T cells and promotion of clinical allergic unresponsiveness.

MUCOSAL IMMUNOLOGY (2021)

Article Immunology

Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade

Christine Bangert et al.

Summary: Therapeutic options for autoimmune diseases typically involve immunosuppressive agents, but sustained clinical benefit is rare. A study on atopic dermatitis patients treated with dupilumab found decreases in skin immune cell counts and normalization of transcriptomic dysregulation. However, specific immune cell populations persisted after clinical remission, indicating a persisting disease memory.

SCIENCE IMMUNOLOGY (2021)

Editorial Material Allergy

The role of immunoglobulin A in oral tolerance and food allergy

Jennifer Pier et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2021)

Article Immunology

Mucosal Nanoemulsion Allergy Vaccine Suppresses Alarmin Expression and Induces Bystander Suppression of Reactivity to Multiple Food Allergens

Mohammad Farazuddin et al.

Summary: The study demonstrates that intranasal immunotherapy using NE-allergen formulation can suppress Th2 immune response and protect mice from food allergen challenges. The protection is associated with higher levels of Th1 cytokines. NE vaccine containing both egg and peanut can significantly reduce reactivity to oral challenges with either allergen.

FRONTIERS IN IMMUNOLOGY (2021)

Review Allergy

Peanut allergy: Beyond the oral immunotherapy plateau

Kelly Bruton et al.

Summary: Oral immunotherapy has potential in peanut allergy treatment but also limitations. Current research focuses on reservoirs of peanut-specific memory B cells and Th2 cells, further investigation into the cellular and molecular interactions is needed to identify new therapeutic targets for the future.

CLINICAL AND TRANSLATIONAL ALLERGY (2021)

Review Immunology

Memory Generation and Re-Activation in Food Allergy

Joshua F. E. Koenig et al.

Summary: Recent studies have highlighted the critical role of memory cells in maintaining lifelong food allergies, particularly in the analysis of allergen-specific B and T cells. The discovery of Th2A and Tfh13 populations has advanced our understanding of allergen-specific T cell phenotypes, although their contribution to IgE memory responses remains unclear.

IMMUNOTARGETS AND THERAPY (2021)

Review Allergy

Use of biologics in food allergy management

M. Worm et al.

Summary: Food allergies are a common medical issue, with children being the most affected group. The standard care involves acute treatment and long-term food avoidance. Current developments in causal treatment, such as specific immunotherapy and biologics, show promising results in improving tolerability and efficacy for food allergy patients.

ALLERGOLOGIE (2021)

Letter Allergy

IgE to galactose-α-1,3-galactose wanes over time in patients who avoid tick bites

Margaret Shin Kim et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

Article Allergy

Peanut-Specific IgA and IgG4 in Saliva are Modulated by Peanut OIT

Michael Kulis et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Allergy

Vaccine against peanut allergy based on engineered virus-like particles displaying single major peanut allergens

Federico Storni et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Review Multidisciplinary Sciences

A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy

Samira Imran et al.

ISCIENCE (2020)

Review Biochemistry & Molecular Biology

Antibody-Drug Conjugates for Cancer Therapy

Umbreen Hafeez et al.

MOLECULES (2020)

Article Allergy

Oral immunotherapy for peanut allergy: The pro argument

R. Sharon Chinthrajah et al.

WORLD ALLERGY ORGANIZATION JOURNAL (2020)

Review Biochemistry & Molecular Biology

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

Mohamed-Reda Benmebarek et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Meeting Abstract Allergy

Safety and Tolerability of a Novel Peptide-Based Immunotherapy for Peanut Allergy

Sara R. Prickett et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Article Allergy

Human BCR analysis of single-sorted, putative IgE+ memory B cells in food allergy

Rodrigo Jimenez-Saiz et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Article Allergy

Individually dosed omalizumab facilitates peanut oral immunotherapy in peanut allergic adolescents

Josef Brandstrom et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2019)

Article Multidisciplinary Sciences

Identification of a T follicular helper cell subset that drives anaphylactic IgE

Uthaman Gowthaman et al.

SCIENCE (2019)

Article Allergy

Long-Term Outcome of Peanut Oral Immunotherapy Facilitated Initially by Omalizumab

Christina S. K. Yee et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

Article Medicine, Research & Experimental

Phase 2a randomized, placebo-controlled study of anti-IL-33 in peanut allergy

Sharon Chinthrajah et al.

JCI INSIGHT (2019)

Article Medicine, General & Internal

Prevalence and Severity of Food Allergies Among US Adults

Ruchi S. Gupta et al.

JAMA NETWORK OPEN (2019)

Article Allergy

Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice

Joseph J. Dolence et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

The Initiation of Th2 Immunity Towards Food Allergens

Yosef Ellenbogen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Allergy

Immune mechanisms of oral immunotherapy

Michael D. Kulis et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Review Allergy

Treatment for food allergy

A. Wesley Burks et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease

J. Morgan Knight et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Medicine, General & Internal

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

M. Castro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Immunology

Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies

Shangjun Sun et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

Review Immunology

Dual Role of Toll-like Receptors in Human and Experimental Asthma Models

Amin Zakeri et al.

FRONTIERS IN IMMUNOLOGY (2018)

Editorial Material Allergy

The IgE memory reservoir in food allergy

Rodrigo Jimenez-Saiz et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Article Environmental Sciences

The Epidemiology of Food Allergy in the Global Context

Wenyin Loh et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Article Medicine, General & Internal

AR101 Oral Immunotherapy for Peanut Allergy

Brian P. Vickery et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Allergy

Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults

Stacie M. Jones et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Allergy

A humanized mouse model of anaphylactic peanut allergy

Oliver T. Burton et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Allergy

Lifelong memory responses perpetuate humoral TH2 immunity and anaphylaxis in food allergy

Rodrigo Jimenez-Saiz et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Allergy

Omalizumab facilitates rapid oral desensitization for peanut allergy

Andrew J. MacGinnitie et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

IgG1 memory B cells keep the memory of IgE responses

Jin-Shu He et al.

NATURE COMMUNICATIONS (2017)

Article Biotechnology & Applied Microbiology

Safety and long-term immunological effects of CryJ2-LAMP plasmid vaccine in Japanese red cedar atopic subjects: A phase I study

Yan Su et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2017)

Article Allergy

Increasing Emergency Department Visits for Anaphylaxis, 2005-2014

Megan S. Motosue et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2017)

Article Allergy

B cells establish, but do not maintain, long-lived murine anti-peanut IgEa

D. M. Moutsoglou et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2016)

Review Allergy

Does atopic dermatitis cause food allergy? A systematic review

Teresa Tsakok et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Allergy

Human B-cell isotype switching origins of IgE

Timothy J. Looney et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Review Allergy

The Natural History of Food Allergy

Jessica Savage et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2016)

Correction Allergy

Safety and feasibility of oral immunotherapy to multiple allergens for food allergy (vol 10, 1, 2014)

Philippe Begin et al.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2016)

Article Medicine, General & Internal

Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy

George Du Toit et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Allergy

Accidental exposures to peanut in a large cohort of Canadian children with peanut allergy

Sabrine Cherkaoui et al.

CLINICAL AND TRANSLATIONAL ALLERGY (2015)

Review Immunology

Regulatory constraints in the generation and differentiation of IgE-expressing B cells

Zhiyong Yang et al.

CURRENT OPINION IN IMMUNOLOGY (2014)

Review Immunology

Peptide based immunotherapy: A pivotal tool for allergy treatment

Kriti Gupta et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2014)

Article Allergy

Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy

Brian P. Vickery et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

Article Allergy

Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity

Oliver T. Burton et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

Article Medicine, General & Internal

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

Lisa A. Beck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Allergy

A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients

Lynda C. Schneider et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Allergy

Sublingual immunotherapy for peanut allergy: A randomized, double-blind, placebo-controlled multicenter trial

David M. Fleischer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Letter Allergy

Sublingual versus oral immunotherapy for peanut-allergic children: A retrospective comparison

Edwin H. Kim et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Allergy

IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses

Willem van de Veen et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Pediatrics

The Economic Impact of Childhood Food Allergy in the United States

Ruchi Gupta et al.

JAMA PEDIATRICS (2013)

Article Allergy

The natural history of persistent peanut allergy

Dara L. Neuman-Sunshine et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2012)

Review Immunology

Characterization of CD4+ T cell subsets in allergy

Erik Wambre et al.

CURRENT OPINION IN IMMUNOLOGY (2012)

Article Immunology

Sequential class switching is required for the generation of high affinity IgE antibodies

Huizhong Xiong et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

Review Immunology

Oral tolerance to food protein

O. Pabst et al.

MUCOSAL IMMUNOLOGY (2012)

Review Biotechnology & Applied Microbiology

The potential of biologics for the treatment of asthma

Girolamo Pelaia et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Medicine, General & Internal

Oral Immunotherapy for Treatment of Egg Allergy in Children

A. Wesley Burks et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Microbiology

Trained Immunity: A Memory for Innate Host Defense

Mihai G. Netea et al.

CELL HOST & MICROBE (2011)

Letter Allergy

Frequency of US emergency department visits for food-related acute allergic reactions

Sunday Clark et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2011)

Review Immunology

Mechanisms maintaining peripheral tolerance

Daniel L. Mueller

NATURE IMMUNOLOGY (2010)

Article Allergy

Clinical efficacy and immune regulation with peanut oral immunotherapy

Stacie M. Jones et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

Article Immunology

T follicular helper cells differentiate from Th2 cells in response to helminth antigens

Arielle Glatman Zaretsky et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

Article Allergy

Orally administered TGF-β is biologically active in the intestinal mucosa and enhances oral tolerance

Takashi Ando et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

Review Food Science & Technology

IgE-Mediated food allergy diagnosis: Current status and new perspectives

Riccardo Asero et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2007)

Article Immunology

Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy

MR Karlsson et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

Article Medicine, General & Internal

Effect of Anti-IgE therapy in patients with peanut allergy

DYM Leung et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)