Progress and challenges in functional nanomaterial-based suspension array technology for multiplexed biodetection

Suspension array technology (SAT) has aroused substantial interest due to its strong multiplexed detection capability, quick binding kinetics, high throughput, and high detection sensitivity. Although rapid developments in material science have led to tremendous progress with regards to SAT, several challenges still exist that limit the performance of SAT, including limited barcode numbers, unpredictable barcode signal and suboptimal detection sensitivity. Therefore, major efforts are still needed to further improve performance to fulfill the higher requirements of precision diagnosis. In this review, we focus on summarizing recent advances regarding encoded microspheres and labels for functional nanomaterial-based suspension array technology, then analyze the current challenges and propose corresponding solutions. We anticipate that this review will be helpful for the future design of functional nanomaterial-based SAT platforms with superior performance.

Automated summary

This review summarizes recent advances in functional nanomaterial-based suspension array technology, analyzes current challenges, and proposes corresponding solutions.