Genetic and molecular biology of gastric cancer among Iranian patients: an update

Background There is a declining trend of gastric cancer (GC) incidence in the world during recent years that is related to the development of novel diagnostic methods. However, there is still a high ratio of GC mortality among the Iranian population that can be associated with late diagnosis. Despite various reports about the novel diagnostic markers, there is not any general and standard diagnostic panel marker for Iranian GC patients. Therefore, it is required to determine an efficient and general panel of molecular markers for early detection. Main body of the abstract In the present review, we summarized all of the reported markers until now among Iranian GC patients to pave the way for the determination of a population-based diagnostic panel of markers. In this regard, we categorized these markers in different groups based on their involved processes to know which molecular process is more frequent during the GC progression among Iranians. Conclusion We observed that the non-coding RNAs are the main factors involved in GC tumorigenesis in this population.

Automated summary

Non-coding RNAs are found to be the main factors involved in gastric cancer tumorigenesis among the Iranian population, highlighting the need for an efficient and general panel of molecular markers for early detection.