期刊
SCIENCE ADVANCES
卷 2, 期 12, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.1601838
关键词
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资金
- International Research and Development Program of the National Research Foundation of Korea (NRF) - Ministry of Science, ICT, and Future Planning (MSIP) [2016K1A3A1A32913356]
- Mid-Career Researcher Support Program through the NRF - MSIP [2016R1A2B3014157]
- Leading Foreign Research Institute Recruitment Program through the NRF - MSIP [2013K1A4A3055268]
- National Research Foundation of Korea [2016K1A3A1A32913356] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Hybrid liposome/metal nanoparticles are promising candidate materials for biomedical applications. However, the poor selectivity and low yield of the desired hybrid during synthesis pose a challenge. We designed a programmable liposome by selective encoding of a reducing agent, which allows self-crystallization of metal nanoparticles within the liposome to produce stable liposome/metal nanoparticles alone. We synthesized seven types of liposome/monometallic and more complex liposome/bimetallic hybrids. The resulting nanoparticles are tunable in size and metal composition, and their surface plasmon resonance bands are controllable in visible and near infrared. Owing to outer lipid bilayer, our liposome/Au nanoparticle shows better colloidal stability in biologically relevant solutions as well as higher endocytosis efficiency than gold nanoparticles without the liposome. We used this hybrid in intracellular imaging of living cells via surface-enhanced Raman spectroscopy, taking advantage of its improved physicochemical properties. We believe that our method greatly increases the utility of metal nanoparticles in in vivo applications.
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