期刊
SCIENCE ADVANCES
卷 2, 期 4, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.1600378
关键词
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资金
- Defense Threat Reduction Agency
- Global Emerging Infections System
- U.S. Centers for Disease Control and Prevention
- Global Biosurveillance Technology Initiative agencies from the U.S. Department of Defense
- U.S. National Institute of Allergy and Infectious Diseases [HHSN272200700016I]
On 29 June 2015, Liberia's respite from Ebola virus disease (EVD) was interrupted for the second time by a renewed outbreak (flare-up) of seven confirmed cases. We demonstrate that, similar to the March 2015 flare-up associated with sexual transmission, this new flare-up was a reemergence of a Liberian transmission chain originating from a persistently infected source rather than a reintroduction from a reservoir or a neighboring country with active transmission. Although distinct, Ebola virus (EBOV) genomes from both flare-ups exhibit significantly low genetic divergence, indicating a reduced rate of EBOV evolution during persistent infection. Using this rate of change as a signature, we identified two additional EVD clusters that possibly arose from persistently infected sources. These findings highlight the risk of EVD flare-ups even after an outbreak is declared over.
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