期刊
KIDNEY360
卷 3, 期 2, 页码 337-340出版社
AMER SOC NEPHROLOGY
DOI: 10.34067/KID.0007702021
关键词
chronic kidney disease; biomarkers; brain; kidney tubules; neuroimaging
资金
- National Institute of Diabetes and Digestive Kidney Diseases (NIDDK) Ruth L. Kirschstein National Research Service Award [5F32DK127590-02]
- NIDDK mid-career mentoring award [K24DK110427]
- NIDDK [R01DK098234, R01AG055606, R01 DK092241]
- Alzheimer's Association
This study is the first evaluation of the relationship between kidney tubule biomarkers and brain imaging by MRI in patients with CKD, and it found that urine biomarker concentrations were not associated with brain MRI measures.
Key Points Urine biomarker concentrations reflecting kidney tubule injury and dysfunction were not associated with brain MRI measures. Higher eGFR was associated with lower total brain cerebral blood flow. This is the first evaluation of the relationship of kidney tubule biomarkers with brain imaging by MRI in patients with CKD.
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