Nanoscale Drug Delivery Systems in Glioblastoma

Glioblastoma is the most aggressive cerebral tumor in adults. However, the current pharmaceuticals in GBM treatment are mainly restricted to few chemotherapeutic drugs and have limited efficacy. Therefore, various nanoscale biomaterials that possess distinct structure and unique property were constructed as vehicles to precisely deliver molecules with potential therapeutic effect. In this review, nanoparticle drug delivery systems including CNTs, GBNs, C-dots, MOFs, Liposomes, MSNs, GNPs, PMs, Dendrimers and Nanogel were exemplified. The advantages and disadvantages of these nanoparticles in GBM treatment were illustrated.

Automated summary

This review illustrates the applications of nanoparticle drug delivery systems in glioblastoma (GBM) treatment. Various nanomaterials are constructed as carriers to precisely deliver molecules with potential therapeutic effect. However, different nanoparticles have their own advantages and disadvantages.