Live Birth with or without Preimplantation Genetic Testing for Aneuploidy

To the Editor: Although the results of the trial conducted by Yan et al. (Nov. 25 issue)(1) were robust, the conclusions may not be generalizable to all clinical practices. The authors chose to make the cumulative live-birth rate the primary outcome; live birth per embryo transfer would have been a more clinically relevant metric. The trial also included only young women with a good prognosis for pregnancy rather than all comers. Given that increasing age is associated with an increased risk of aneuploidy, this choice arouses concern about the incidence of aneuploidy among the women included in the study and . . .

Automated summary

This article points out a limitation of a clinical study, stating that its conclusions have certain limitations and may not be applicable to all clinical practices. The choice of outcome measures in the study may also lack clinical relevance, and there are restrictions on the study population, which raises concerns about the incidence of aneuploidy among the subjects.