期刊
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
卷 63, 期 2, 页码 -出版社
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.63.2.12
关键词
mouse model; conventional outflow; glaucoma; intraocular pressure; ocular hypertension; outflow facility
资金
- Aerie Pharmaceuticals, Inc.
- Aerpio Pharmaceuticals, Inc.
- Allergan
- Bausch + Lomb
- BrightFocus Foundation
- Glaucoma Research Foundation
- Glaukonix, Inc.
- Glaukos Corp.
- Nicox Visible Science
- Novartis Pharmaceuticals, Inc.
- Regeneron Pharmaceuticals
- Santen, Inc.
- Western Glaucoma Foundation
This article highlights the importance of using mice as a valuable model system for studying conventional outflow resistance and intraocular pressure. It also outlines the minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. These standards are expected to enhance scientific rigor and replicability of research findings.
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据