期刊
DALTON TRANSACTIONS
卷 51, 期 11, 页码 4429-4434出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2dt00243d
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资金
- National Science Centre (Poland) [UMO-2016/23/D/ST5/00417]
In this study, eight rhodium complexes were prepared and found to be catalytically active in the hydrothiolation of terminal alkynes. The steric bulk of the carbene was found to significantly affect the reaction rate and selectivity. The experimental conditions were optimized to enable efficient synthesis of α-vinyl sulfides with high atom economy and low catalyst loading.
Eight rhodium complexes-including four new compounds-with the generic formula [RhCl(cod)(NHC)] (cod is 1,3-cyclooctadiene) differing by the size of their N-heterocyclic carbene (NHC) ligand were prepared, characterized, and found to be catalytically active in the hydrothiolation of terminal alkynes with aliphatic or aromatic thiols. The steric bulk of the carbene was found to markedly influence the reaction rate and selectivity. In particular, superbulky NHCs led to the almost quantitative formation of the sole alpha-vinyl sulfide products. The experimental conditions were optimized to allow the straightforward synthesis of a broad range of mono- and disubstituted alpha-adducts starting from terminal alkynes (18 examples) and thiols (5 examples). Altogether, the procedure devised in this study provides an easy access to alpha-vinyl sulfides with full atom economy and a low catalyst loading.
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