期刊
MATERIALS ADVANCES
卷 3, 期 8, 页码 3582-3592出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ma01243f
关键词
-
资金
- Spanish MCIN/AIE
- ERDF A way of making Europe
- European Union [CTQ2015-74494-JIN, RTI2018-099504-B-C21, PID2019-109742GB-I00]
- Agencia de Desarrollo Economico de La Rioja (Gobierno de la Rioja) [2017-I-IDD-00031]
- University of Alicante through the Programa de Retencion de Talento [UATALENTO16-03]
- Instituto de Salud Carlos III [CPII20/00029]
- European Social Fund (ESF) Investing in your future
- Spanish Association Against Cancer (AECC)
This study presents an in situ strategy for the synthesis and surface functionalization of highly luminescent mesoporous organometallo-silica nanoparticles. Three different emissive mesoporous nanoparticles were prepared with strong phosphorescence, biocompatibility, and efficient internalization. One of the nanoparticles also exhibited excellent colloidal stability and a large surface area.
Production of mesoporous silica nanoparticles (MSNs) with uniform textural characteristics and imaging properties on a large scale is still a challenge. Thus, the design of simple and scalable methods to obtain reproducible functionalized MSNs has become even more relevant. Herein, we describe an in situ strategy for the synthesis and surface functionalization of highly luminescent mesoporous organometallo-silica nanoparticles. Using the [Ir(dfppy)(2)(dasipy)]PF6 chromophore and TEOS as sol-gel precursors and different capping agents, such as DMDES or APTES, three different emissive MSNs were prepared (NPOH_IS, NPMe_IS and NPNH2_IS), each containing hydroxyl, methyl and amine groups on their surfaces, respectively. All three were tested on human tumor A549 (lung carcinoma) and HeLa (cervix carcinoma) cell lines, showing intense and stable yellow phosphorescence, biocompatibility and efficient internalization. Moreover, NPMe_IS nanoparticles showed excellent colloidal stability, both in water and biological media, and a BET area of 1120 m(2) g(-1), making them not only luminescent biomarkers, but potentially also controlled delivery vectors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据