4.2 Article

Highly emissive hybrid mesoporous organometallo-silica nanoparticles for bioimaging

期刊

MATERIALS ADVANCES
卷 3, 期 8, 页码 3582-3592

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ma01243f

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资金

  1. Spanish MCIN/AIE
  2. ERDF A way of making Europe
  3. European Union [CTQ2015-74494-JIN, RTI2018-099504-B-C21, PID2019-109742GB-I00]
  4. Agencia de Desarrollo Economico de La Rioja (Gobierno de la Rioja) [2017-I-IDD-00031]
  5. University of Alicante through the Programa de Retencion de Talento [UATALENTO16-03]
  6. Instituto de Salud Carlos III [CPII20/00029]
  7. European Social Fund (ESF) Investing in your future
  8. Spanish Association Against Cancer (AECC)

向作者/读者索取更多资源

This study presents an in situ strategy for the synthesis and surface functionalization of highly luminescent mesoporous organometallo-silica nanoparticles. Three different emissive mesoporous nanoparticles were prepared with strong phosphorescence, biocompatibility, and efficient internalization. One of the nanoparticles also exhibited excellent colloidal stability and a large surface area.
Production of mesoporous silica nanoparticles (MSNs) with uniform textural characteristics and imaging properties on a large scale is still a challenge. Thus, the design of simple and scalable methods to obtain reproducible functionalized MSNs has become even more relevant. Herein, we describe an in situ strategy for the synthesis and surface functionalization of highly luminescent mesoporous organometallo-silica nanoparticles. Using the [Ir(dfppy)(2)(dasipy)]PF6 chromophore and TEOS as sol-gel precursors and different capping agents, such as DMDES or APTES, three different emissive MSNs were prepared (NPOH_IS, NPMe_IS and NPNH2_IS), each containing hydroxyl, methyl and amine groups on their surfaces, respectively. All three were tested on human tumor A549 (lung carcinoma) and HeLa (cervix carcinoma) cell lines, showing intense and stable yellow phosphorescence, biocompatibility and efficient internalization. Moreover, NPMe_IS nanoparticles showed excellent colloidal stability, both in water and biological media, and a BET area of 1120 m(2) g(-1), making them not only luminescent biomarkers, but potentially also controlled delivery vectors.

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