期刊
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
卷 37, 期 1, 页码 160-172出版社
OXFORD UNIV PRESS
DOI: 10.1093/arclin/acab033
关键词
Proton-magnetic resonance spectroscopy; Methamphetamine; Neuropsychological deficits
资金
- Iran University of Medical Sciences [4956]
This study aimed to examine the relationship between brain metabolite alterations in frontostriatal regions and neuropsychological deficits in patients with methamphetamine use disorder. The findings indicated significant differences in metabolite ratios and poorer performance in neuropsychological tests among methamphetamine users compared to controls. Furthermore, a significant relationship was found between regional metabolite alterations, particularly in the ACC, and neuropsychological deficits in methamphetamine users.
Introduction: Chronic use of methamphetamine induces neuropsychological deficits and neurochemical changes in frontostriatal regions. This study aimed to examine the relationship between brain metabolites alterations in frontostriatal regions and neuropsychological deficits in patients with methamphetamine use disorder. Method: A total of 30 methamphetamine users and 20 control participants were selected and a battery of standardized executive function, attention, and memory tasks, including theWisconsin Card Sorting Test, Stroop Test, andWechsler Memory Scale, was administered to them. Proton-Magnetic resonance spectroscopy (H-MRS) of N-Acetylaspartate/Creatine (NAA/Cr), Choline/Creatine (Cho/Cr), and glutamate + glutamine/creatine (Glx/Cr) in dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), and basal ganglia (BG) were also undertaken. Results: Current findings indicated that there were significant differences between two groups in metabolite ratios including NAA/Cr, Cho/Cr, and Glx/Cr in three areas, except for Glx/Cr in BG. Moreover, compared to healthy controls, methamphetamine users showed poorer performance in all neuropsychological tests. Finally, a significant relationship was found between regional metabolites alterations, particularly in the ACC, and neuropsychological deficits in methamphetamine users. Conclusions: In addition to neurochemical changes and neuropsychological deficits in patients with methamphetamine use disorder, current results highlighted the relationship between these changes in DLPFC, ACC, and BG with cognitive deficits in methamphetamine users.
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