期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 10, 期 12, 页码 1897-1907出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb02554f
关键词
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资金
- Key R&D Plan of Jiangsu Province [BE2018010-3]
- National Natural Science Foundation of China [31800803, 32071364]
- National Key R&D Program of China [2020YFA0710800]
- Scientific Research Foundation for Talent Introduction of Nanjing Tech University [39803129, 39803130]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Three-dimensional (3D) bioprinting plays a crucial role in tissue engineering. The emerging solution of embedded bioprinting addresses the challenges faced in traditional bioprinting by depositing bioinks into a support bath. This review focuses on the progress of hydrogels used as bioinks and support baths.
Three-dimensional (3D) bioprinting has played an increasingly crucial role in the manufacturing of organized complex tissues and organs, which has shown tremendous potential in the field of tissue engineering. Extrusion-based bioprinting takes advantage of its competitive pricing and flexibility to print various biomaterials, and it has now developed into one of the most used printing techniques. However, extruding soft hydrogels, also known as bioinks, often leads to poor fidelity when printed in air. As an emerging printing approach, 3D embedded bioprinting deposits bioinks not on a platform but into a support bath, preventing constructs from settling and collapsing. This review discusses the challenges faced in the traditional 3D bioprinting of soft or low-viscosity bioinks and the changes brought by embedded bioprinting as an emerging solution. Particular focus is given to the progress of hydrogels used as bioinks and support baths. Finally, we highlight the challenges involved in this process and look forward to the prospects of this technology.
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