期刊
NATURE MICROBIOLOGY
卷 1, 期 9, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMICROBIOL.2016.103
关键词
-
类别
资金
- Japan Science and Technology Agency, JSPS KAKENHI [15H04732]
- Yakult Bio-Science Foundation
- Naito Memorial Foundation
- Senshin Medical Research Foundation
- Astellas Foundation for Research on Metabolic Disorders
- AMED-CREST, AMED
- RIKEN Pioneering Project 'Biology of Symbiosis'
- Grants-in-Aid for Scientific Research [16H05207, 16K18711, 15H04732, 16J11295, 25112006] Funding Source: KAKEN
Immunoglobulin A (IgA) is the main antibody isotype secreted into the intestinal lumen. IgA plays a critical role in the defence against pathogens and in the maintenance of intestinal homeostasis. However, how secreted IgA regulates gut microbiota is not completely understood. In this study, we isolated monoclonal IgA antibodies from the small intestine of healthy mouse. As a candidate for an efficient gut microbiota modulator, we selected a W27 IgA, which binds to multiple bacteria, but not beneficial ones such as Lactobacillus casei. W27 could suppress the cell growth of Escherichia coli but not L. casei in vitro, indicating an ability to improve the intestinal environment. Indeed W27 oral treatment could modulate gut microbiota composition and have a therapeutic effect on both lymphoproliferative disease and colitis models in mice. Thus, W27 IgA oral treatment is a potential remedy for inflammatory bowel disease, acting through restoration of host-microbial symbiosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据