☆ 4.2 Review

Ofeleein i mi Vlaptin-Volume II: Immunity Following Infection or mRNA Vaccination, Drug Therapies and Non-Pharmacological Management at Post-Two Years SARS-CoV-2 Pandemic

MEDICINA-LITHUANIA (2022)

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Review Immunology

Airborne or Droplet Precautions for Health Workers Treating Coronavirus Disease 2019?

Prateek Bahl et al.

Summary: Cases of COVID-19 have been reported worldwide, with a high number of healthcare workers being infected. There are conflicting guidelines for COVID-19 prevention, and the available evidence does not support droplet precautions and a 1- to 2-meter spatial separation rule.

JOURNAL OF INFECTIOUS DISEASES (2022)

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Review Pediatrics

Should children be vaccinated against COVID-19?

Petra Zimmermann et al.

Summary: The debate over whether all children under 12 should be vaccinated against COVID-19 continues, with considerations including the relatively low risk of acute COVID-19 in children and the complexity of weighing the risks and benefits of vaccination. Other factors to consider include protection from long-term consequences, population-level impacts, vaccine supply, cost, and avoiding quarantine measures. Ongoing evaluation is needed due to the emergence of new variants of concern.

ARCHIVES OF DISEASE IN CHILDHOOD (2022)

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Article Allergy

Assessment of hand hygiene strategies on skin barrier function during COVID-19 pandemic: A randomized clinical trial

Trinidad Montero-Vilchez et al.

Summary: This study compared the impact of different hand hygiene measures on skin barrier function in healthcare workers. The results showed that daily hand hygiene with alcohol-based hand sanitizers (ABHS) caused the least disruption to the skin barrier and had the highest reduction in bacteria.

CONTACT DERMATITIS (2022)

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Article Oncology

Immunogenicity and Reactogenicity of SARS-CoV-2 Vaccines in Patients With Cancer: The CANVAX Cohort Study

Vivek Naranbhai et al.

Summary: The study investigated the immune responses to SARS-CoV-2 vaccines in cancer patients, showing that the vaccine-induced immune responses were quantitatively lower in cancer patients compared to healthy controls, recommending antibody testing to identify those who may benefit from additional vaccine doses.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Immunology

Reduced Magnitude and Durability of Humoral Immune Responses to COVID-19 mRNA Vaccines Among Older Adults

Mark A. Brockman et al.

Summary: Humoral responses to COVID-19 mRNA vaccines are significantly weaker in older adults, and decline over time. Age is a significant predictor of antibody concentration and virus neutralizing activity, even after adjusting for participant demographics.

JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Oncology

Angioimmunoblastic T-cell lymphoma: treatment strategies and prognostic factors from a retrospective multicenter study in China

Chen Zhang et al.

Summary: This study evaluated treatment programs and prognostic factors of 121 newly diagnosed AITL patients in China, identifying a novel prognostic model including the involvement of nodal areas, age, and Beta-2 microglubulin as highly predictive factors for overall survival.

LEUKEMIA & LYMPHOMA (2022)

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Article Immunology

Large-Scale Study of Antibody Titer Decay following BNT162b2 mRNA Vaccine or SARS-CoV-2 Infection

Ariel Israel et al.

Summary: This study demonstrates that individuals who received the Pfizer-BioNTech mRNA vaccine have higher initial levels of antibodies compared to patients who had been infected with the SARS-CoV-2 virus, but experience a much faster exponential decrease in antibody levels.

VACCINES (2022)

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Article Immunology

A randomized controlled clinical trial on efficacy and safety of anakinra in patients with severe COVID-19

Amir Behnam Kharazmi et al.

Summary: In severe COVID-19 patients, treatment with Anakinra significantly reduced the need for mechanical ventilation and resulted in a shorter hospital stay compared to the control group. There was no significant increase in the risk of infection observed in the study.

IMMUNITY INFLAMMATION AND DISEASE (2022)

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Article Pharmacology & Pharmacy

COVID-19 vaccine use in immunocompromised patients: A commentary on evidence and recommendations

Kristine Duly et al.

Summary: Despite the exclusion of immunocompromised patients from phase 3 COVID-19 vaccine trials, recent data has shown reassuring results on safety and efficacy in this population. Recommendations from various government and professional organizations endorse COVID-19 vaccination in immunocompromised individuals, with ongoing efforts to educate and reassure them to decrease vaccine hesitancy. Further data is needed to fully assess the impact of immunocompromising conditions and immunosuppressing medications on vaccine efficacy.

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2022)

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Review Immunology

Ivermectin for the Treatment of Coronavirus Disease 2019: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Yuani M. Roman et al.

Summary: This systematic review found that in patients with mostly mild COVID-19, ivermectin did not reduce all-cause mortality, hospital stays, or viral clearance compared to the control group. Therefore, ivermectin is not a viable treatment option for COVID-19.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Immunology

Neutralizing Monoclonal Antibody Treatment Reduces Hospitalization for Mild and Moderate Coronavirus Disease 2019 (COVID-19): A Real-World Experience

John Paul Verderese et al.

Summary: In a real-life clinical setting, neutralizing monoclonal antibody (NmAb) treatment significantly reduced hospital utilization among patients with COVID-19 with mild to moderate disease, especially if received within 4 days after symptom onset.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Decline of antibody titres 3 months after two doses of BNT162b2 in non-immunocompromised adults

Alejo Erice et al.

Summary: The study found that after receiving the BNT162b2 vaccine, the antibody levels in some adults declined after 3 months, indicating the possible need for additional doses to maintain high levels of antibodies.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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Letter Gastroenterology & Hepatology

Letter to the Editor: Autoimmune hepatitis after COVID-19 vaccination: A rare adverse effect?

Panagiota Palla et al.

HEPATOLOGY (2022)

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Article Medicine, General & Internal

Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19

Sebastian Havervall et al.

Summary: Emerging data suggests detectable immune responses can last for months after SARS-CoV-2 infection or vaccination, but the degree and duration of protection against reinfection remains uncertain. A study on healthcare workers and COVID-19 patients found that the majority of individuals tested positive for anti-spike IgG antibodies remained positive for at least 8 months, with a significantly reduced risk of reinfection up to 9 months following asymptomatic to mild COVID-19.

JOURNAL OF INTERNAL MEDICINE (2022)

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Letter Gastroenterology & Hepatology

Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed

Gloria Shwe Zin Tun et al.

JOURNAL OF HEPATOLOGY (2022)

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Article Oncology

Mutations in TP53 or DNA damage repair genes define poor prognostic subgroups in primary prostate cancer

Cathleen Nientiedt et al.

Summary: Mutations in TP53 or DNA damage repair genes are frequently detected in primary prostate cancer with high-risk features, and are associated with a worse prognosis and an increased risk for PSA failure or persistence after radical prostatectomy. These alterations can be used to identify men with prostate cancer who may benefit from intensified treatment.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2022)

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Article Immunology

Tocilizumab for Treatment of Mechanically Ventilated Patients With COVID-19

Emily C. Somers et al.

Summary: In mechanically ventilated COVID-19 patients, the use of IL-6 blockade with tocilizumab was associated with lower mortality despite higher occurrence of superinfections.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Immunology

Remdesivir for Severe Coronavirus Disease 2019 (COVID-19) Versus a Cohort Receiving Standard of Care

Susan A. Olender et al.

Summary: In a comparative analysis, remdesivir was found to be associated with significantly higher recovery rates and a 62% reduced mortality rate compared to standard-of-care treatment by day 14 in patients with severe COVID-19.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Respiratory System

Rationale and evidence on the use of tocilizumab in COVID-19: a systematic review

A. Cortegiani et al.

Summary: Current evidence on the clinical efficacy and safety of tocilizumab in patients with COVID-19 is insufficient, further trials are needed. Its use should be considered experimental, requiring ethical approval and clinical trial oversight.

PULMONOLOGY (2021)

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Review Virology

Convalescent plasma is a clutch at straws in COVID-19 management! A systematic review and meta-analysis

Soumya Sarkar et al.

Summary: Convalescent plasma therapy (CPT) may help reduce mortality, accelerate viral clearance, and improve clinical conditions in COVID-19 patients, but the existing evidence is of low quality. Further randomized controlled trials are needed to confirm the safety and effectiveness of CPT.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Medicine, General & Internal

Dexamethasone in Hospitalized Patients with Covid-19

Peter Horby et al.

Summary: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Editorial Material Health Care Sciences & Services

Consequences of the COVID-19 Pandemic: Reduced Hemoglobin A1c Diabetes Monitoring

Maren S. Fragala et al.

POPULATION HEALTH MANAGEMENT (2021)

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Review Biology

Repurposing Colchicine in Treating Patients with COVID-19: A Systematic Review and Meta-Analysis

Chi-Hone Lien et al.

Summary: This systematic review evaluated the effects of colchicine treatment in COVID-19 patients, finding that colchicine treatment was associated with a significantly lower risk of mortality. However, this benefit was not observed in the subgroup analysis of randomized controlled trials. Further studies are required to confirm the potential benefits of colchicine treatment.

LIFE-BASEL (2021)

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Article Rheumatology

Humoral and cellular responses to mRNA vaccines against SARS-CoV-2 in patients with a history of CD20 B-cell-depleting therapy (RituxiVac): an investigator-initiated, single-centre, open-label study

Matthias B. Moor et al.

Summary: The study investigated immune responses to SARS-CoV-2 mRNA vaccines in patients receiving CD20-targeted B-cell-depleting therapies. Results showed blunted immune responses in these patients, indicating potential challenges in vaccination strategies for this population.

LANCET RHEUMATOLOGY (2021)

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Review Endocrinology & Metabolism

Ivermectin and mortality in patients with COVID-19: A systematic review, meta-analysis, and meta-regression of randomized controlled trials

Ahmad Fariz Malvi Zamzam Zein et al.

Summary: This study showed that ivermectin has a beneficial effect on reducing mortality in patients with COVID-19, especially in severe cases. Hypertension may reduce the benefit of ivermectin, while age, sex, and diabetes do not seem to have a significant impact on its effectiveness.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

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Article Allergy

COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in emergency department

Mathias Van Singer et al.

Summary: This study found that specific biomarkers in the concentrations at clinical presentation in the emergency department of COVID-19 patients had good accuracy in predicting 30-day intubation/mortality and oxygen requirement, serving as potential early triage tools for identifying patients with adverse outcomes.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia A Randomized Clinical Trial

Olivier Hermine et al.

Summary: In this clinical trial of COVID-19 patients with pneumonia requiring oxygen support but not in the ICU, tocilizumab did not reduce WHO-CPS scores below 5 by day 4 but may have reduced the risk of needing noninvasive ventilation, mechanical ventilation, or death by day 14. There was no difference in mortality by day 28. Further studies are needed to confirm these preliminary results.

JAMA INTERNAL MEDICINE (2021)

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Article Public, Environmental & Occupational Health

Case Report: Home-based Management of Severe COVID-19 with Low-dose Tofacitinib

Ashish Sharma et al.

Summary: The COVID-19 pandemic has had a severe impact globally, with systemic glucocorticoid being the first-line therapy for severe cases. During the peak crisis in India, patients treated with oral medications at home due to hospital bed shortages showed promising results in managing severe COVID-19 outside the hospital setting.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2021)

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Editorial Material Medicine, General & Internal

The Role of Masks in Mitigating the SARS-CoV-2 Pandemic: Another Piece of the Puzzle

Christine Laine et al.

ANNALS OF INTERNAL MEDICINE (2021)

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Editorial Material Medicine, General & Internal

Of Masks and Methods

Thomas R. Frieden et al.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Medicine, General & Internal

Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers A Randomized Controlled Trial

Henning Bundgaard et al.

Summary: According to a randomized controlled trial conducted in Denmark, recommending surgical mask use did not significantly reduce the SARS-CoV-2 infection rate, but the results indicated that there may still be some degree of self-protection as suggested by the confidence intervals and related research.

ANNALS OF INTERNAL MEDICINE (2021)

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Review Rheumatology

Anti-inflammatory therapy for COVID-19 infection: the case for colchicine

Aaron Z. Reyes et al.

Summary: The search for effective COVID-19 management strategies is ongoing, with colchicine showing promise in targeting multiple mechanisms associated with excessive inflammation. Outpatient treatment with colchicine could potentially reduce the need for hospitalization and mortality due to COVID-19, benefiting both resource-replete and resource-poor regions by reducing the demand for rare or expensive care resources.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Article Medicine, General & Internal

Assessing mandatory stay-at-home and business closure effects on the spread of COVID-19

Eran Bendavid et al.

Summary: The study found that implementing any NPIs led to significant reductions in case growth in most countries, but after accounting for other factors, there was no clear beneficial effect of more restrictive NPIs on case growth. Similar reductions in case growth may be achievable with less-restrictive interventions.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Review Pharmacology & Pharmacy

A systematic review of experimental evidence for antiviral effects of ivermectin and an in silico analysis of ivermectin's possible mode of action against SARS-CoV-2

Robert T. Kinobe et al.

Summary: Ivermectin has shown potential as an antiviral agent by inhibiting viral replication in vitro, including various virus families. The drug may target nuclear location signals in the SARS-CoV-2 genome, potentially blocking viral proteins from reaching a virus-resistant state. While initial studies show promising results, further research is needed to validate the efficacy of ivermectin in clinical settings.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2021)

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Letter Cardiac & Cardiovascular Systems

Impact of colchicine on mortality in patients with COVID-19: A meta-analysis

Dimitrios A. Vrachatis et al.

HELLENIC JOURNAL OF CARDIOLOGY (2021)

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Article Chemistry, Physical

Molecular docking identification for the efficacy of some zinc complexes with chloroquine and hydroxychloroquine against main protease of COVID-19

R. K. Hussein et al.

Summary: Recent research has shown that using Zinc complexes as add-on to Chloroquine/Hydroxychloroquine is an effective treatment for COVID-19. Molecular docking and dynamics techniques have been proven powerful in establishing therapeutic strategies, with Zn(QC)Cl2(H2O) and Zn(HQC)Cl2(H2O) identified as potential inhibitors for COVID-19 Mpro.

JOURNAL OF MOLECULAR STRUCTURE (2021)

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Article Cardiac & Cardiovascular Systems

COVID-19 vaccination in patients with heart failure: a position paper of the Heart Failure Association of the European Society of Cardiology

Giuseppe Rosano et al.

Summary: Patients with heart failure who contract SARS-CoV-2 infection are at higher risk of morbidity and mortality. COVID-19 vaccination is recommended for all patients with HF, including those who are immunocompromised or frail. After vaccination, patients should continue precautionary measures such as wearing masks, practicing hand hygiene, and maintaining social distancing.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

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Article Public, Environmental & Occupational Health

Environment-lockdown, air pollution and related diseases: could we learn something and make it last?

Marija Jevtic et al.

Summary: The pandemic has led to improvements in air quality due to lockdown measures, which in turn reduce the risk of various diseases. Continued monitoring of air quality changes and persistent efforts to improve air quality are necessary to lower health risks.

EUROPEAN JOURNAL OF PUBLIC HEALTH (2021)

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Article Medicine, General & Internal

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

R. Libster et al.

Summary: A randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against SARS-CoV-2 in older adult patients within 72 hours after the onset of mild Covid-19 symptoms found that early administration of high-titer convalescent plasma reduced the progression of Covid-19 in mildly ill infected older adults.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

A. C. Kalil et al.

Summary: Combination treatment with baricitinib plus remdesivir was superior to remdesivir alone in reducing recovery time and accelerating improvement in clinical status among patients with Covid-19, notably among those receiving high-flow oxygen or noninvasive ventilation. The combination was associated with fewer serious adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

Carlos Salama et al.

Summary: Among hospitalized patients with Covid-19 pneumonia not on mechanical ventilation, tocilizumab reduced the risk of progression to mechanical ventilation or death, but did not improve overall survival. There were no new safety concerns identified.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

Peter Chen et al.

Summary: LY-CoV555, a neutralizing antibody, showed promising results in reducing viral load, improving symptoms, and lowering the risk of hospitalization among patients with mild or moderate Covid-19. While one of the doses appeared to accelerate the decline in viral load, others did not show significant effects by day 11.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Critical Care Medicine

Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial

Xavier Mariette et al.

Summary: The study aimed to determine the effectiveness of anakinra in improving outcomes of patients with mild-to-moderate COVID-19 pneumonia, but the results showed that anakinra did not show improvement in patient outcomes. Further studies are needed to assess the efficacy of anakinra in other selected groups of patients with more severe COVID-19.

LANCET RESPIRATORY MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Meta-analysis of the Effect of Colchicine on Mortality and Mechanical Ventilation in COVID-19

Husam M. Salah et al.

AMERICAN JOURNAL OF CARDIOLOGY (2021)

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Article Microbiology

Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity against SARS-CoV-2

Wendy P. Painter et al.

Summary: Molnupiravir showed rapid appearance and dose-proportional increase in plasma, with good tolerability in healthy volunteers. The study evaluated single and multiple doses of molnupiravir and the impact of food on pharmacokinetics in subjects, showing no accumulation following multiple doses and a decrease in absorption rate when administered with food, but no decrease in overall exposure.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Editorial Material Medicine, General & Internal

Implementing digital passports for SARS-CoV-2 immunization in Canada

Kumanan Wilson et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2021)

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Article Medicine, General & Internal

SARS-CoV-2 re-infection risk in Austria

Stefan Pilz et al.

Summary: According to the study in Austria, the rate of SARS-CoV-2 re-infections is relatively low. Protection against SARS-CoV-2 after natural infection is comparable to the highest estimates of vaccine efficacies.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Immunology

SARS-CoV-2 re-infection rate in Iranian COVID-19 cases within one-year follow-up

Mostafa Salehi-Vaziri et al.

Summary: This study conducted in the Iranian population found a low incidence rate of SARS-CoV-2 reinfection, with natural infection providing good protection against re-infection, highlighting the significant impact mass vaccination can have on society.

MICROBIAL PATHOGENESIS (2021)

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Review Biochemistry & Molecular Biology

Discovery, Development, and Patent Trends on Molnupiravir: A Prospective Oral Treatment for COVID-19

Mohd Imran et al.

Summary: Molnupiravir, developed initially for influenza treatment, has shown promising activity against various viruses, including SARS-CoV-2. With good safety profile and oral bioavailability, it is currently in development for treating COVID-19 and expected to be available in an oral dosage form in 2022. Patent data suggests potential combinations with other drugs to enhance efficacy.

MOLECULES (2021)

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Article Infectious Diseases

COVID-19 convalescent plasma treatment of moderate and severe cases of SARS-CoV-2 infection: A multicenter interventional study

Sondas Alsharidah et al.

Summary: A study conducted in Kuwait showed that COVID-19 convalescent plasma (CCP) therapy is associated with higher clinical improvement rates and shorter time to clinical improvement for patients with moderate and severe disease. Patients treated with CCP showed improvements in oxygen saturation, lymphocyte counts, and C-reactive protein levels.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Monoclonal Antibodies for COVID-19

Elizabeth C. Lloyd et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Letter Medicine, General & Internal

Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19

Courtney Temple et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19

D. M. Weinreich et al.

Summary: REGEN-COV reduced the risk of Covid-19-related hospitalization or death, resolved symptoms, and reduced the SARS-CoV-2 viral load more rapidly than the placebo.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab

Anil Gupta et al.

Summary: In this study, among nonhospitalized patients with symptomatic Covid-19, sotrovimab treatment significantly reduced the risk of disease progression leading to hospitalization or death compared to placebo. Patients receiving sotrovimab also had a lower rate of serious adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Allergy

Anakinra combined with methylprednisolone in patients with severe COVID-19 pneumonia and hyperinflammation: An observational cohort study

Giorgio Bozzi et al.

Summary: The study involving 120 COVID-19 patients showed that treatment with anakinra plus methylprednisolone could reduce the risk of death, especially in patients with hyperinflammation and respiratory failure. Randomized controlled trials are needed to confirm these findings.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Emergency Medicine

Diagnosis and Acute Management of COVID-19 and Multisystem Inflammatory Syndrome in Children

Teresa B. Kortz et al.

Summary: This article emphasizes the importance of rapid identification and treatment for critically ill children, and provides an overview of the epidemiology, clinical assessment, high-risk patient identification, and COVID-19 management in the emergency department.

PEDIATRIC EMERGENCY CARE (2021)

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Review Medicine, General & Internal

Efficacy and safety of ivermectin for the treatment of COVID-19: a systematic review and meta-analysis

J. Deng et al.

Summary: This systematic review and meta-analysis evaluated the efficacy and safety of ivermectin for treating COVID-19 based on peer-reviewed randomized controlled trials and observational studies. The results showed that ivermectin was not associated with significant reductions in time to viral clearance, duration of hospitalization, mortality, or incidence of mechanical ventilation. These findings suggest that ivermectin may not be effective in managing COVID-19.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2021)

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Review Medicine, General & Internal

Dexamethasone for treating SARS-CoV-2 infection: a systematic review and meta-analysis

Lirane Elize Defante Ferreto et al.

Summary: This study suggests that dexamethasone may significantly improve outcomes for hospitalized patients with SARS-CoV-2 infection and associated severe respiratory complications. Further studies should consider dose-dependent administration and outcomes in both early and later stages of the disease.

SAO PAULO MEDICAL JOURNAL (2021)

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Article Multidisciplinary Sciences

Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma

For Yue Tso et al.

Summary: Specific IgG antibodies against SARS-CoV-2 were detected in all COVID-19 subjects, with most of them also showing high neutralizing potency and strong ADCC activity. These findings suggest that protection against SARS-CoV-2 may not only rely on neutralizing antibodies but also on ADCC mediated by both neutralizing and non-neutralizing antibodies.

PLOS ONE (2021)

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Review Respiratory System

Systematic review and meta-analysis of anakinra, sarilumab, siltuximab and tocilizumab for COVID-19

Fasihul A. Khan et al.

Summary: Through systematic review and meta-analysis, tocilizumab was associated with a lower relative risk of mortality in COVID-19 patients, but effects on other outcomes were inconclusive. Current evidence for the efficacy of anakinra, siltuximab or sarilumab in COVID-19 is insufficient, with further studies urgently needed for conclusive findings.

THORAX (2021)

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Article Medicine, General & Internal

Methylprednisolone in adults hospitalized with COVID-19 pneumonia An open-label randomized trial (GLUCOCOVID)

Luis Corral-Gudino et al.

Summary: This study aimed to investigate whether methylprednisolone improves outcomes in severe COVID-19 patients. Results showed that patients on methylprednisolone had a significantly lower risk of experiencing the composite endpoint in the per protocol analysis. However, the planned sample size was not achieved, cautioning interpretation of the results.

WIENER KLINISCHE WOCHENSCHRIFT (2021)

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Article Virology

Function Is More Reliable Than Quantity to Follow Up the Humoral Response to the Receptor-Binding Domain of SARS-CoV-2-Spike Protein after Natural Infection or COVID-19 Vaccination

Carlos A. Sariol et al.

Summary: The study found that despite a decline in total S-specific antibodies in some patients, neutralizing antibody titers could remain at a similar level for an average of 98 days. The immune response to natural infection differs from that of vaccination, with natural infection inducing a more robust humoral immune response in unexposed subjects. Functional neutralizing antibody tests are more relevant indicators for monitoring the immune response compared to the presence or absence of binding antibodies.

VIRUSES-BASEL (2021)

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Article Virology

SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro (Publication with Expression of Concern. See vol. 14, 2022)

Hui Jiang et al.

Summary: SARS-CoV-2 infection inhibits adaptive immunity and the spike protein may affect adaptive immunity by impeding DNA damage repair through inhibiting key DNA repair proteins' recruitment. The spike protein was found to localize in the nucleus and inhibit DNA damage repair, which may have implications for virus vaccines.

VIRUSES-BASEL (2021)

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Article Immunology

Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia

Andre Santa Cruz et al.

Summary: Hyper-inflammatory responses induced by SARS-CoV-2 are major factors in disease severity and death, with IL-6 levels showing a significant correlation with disease stages and outcomes in COVID-19 patients, particularly in relation to respiratory failure. IL-6 also outperforms CRP as a predictive marker for disease progression.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individuals

Kenji Maeda et al.

Summary: The study found that the BNT162b2 vaccine can significantly increase neutralizing activity against SARS-CoV-2, but there are differences in different age groups and genders, as well as concerns about the duration of neutralizing capability and effectiveness against variant strains.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Correlation of mutational landscape and survival outcome of peripheral T-cell lymphomas

Yingying Ye et al.

Summary: The study found a correlation between mutation landscape and clinical outcomes in patients with peripheral T-cell lymphoma (PTCL). TET2/TP53 mutations were identified as risk factors for patient survival.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2021)

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News Item Medicine, General & Internal

Covid-19: Do vaccines work against omicron-and other questions answered

Elisabeth Mahase

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Pharmacology & Pharmacy

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

Pierre Kory et al.

Summary: In the context of the COVID-19 pandemic, ivermectin has emerged as a promising treatment option with significant improvements in clinical outcomes and reduced risks of contracting the virus being reported in numerous trials. Additionally, evidence suggests that ivermectin distribution campaigns have led to population-wide decreases in morbidity and mortality, indicating its effectiveness across all phases of the disease.

AMERICAN JOURNAL OF THERAPEUTICS (2021)

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Article Clinical Neurology

Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia

Mayte Sanchez van Kammen et al.

Summary: This study found that patients with cerebral venous sinus thrombosis after COVID-19 vaccination who met the criteria for TTS had distinct clinical characteristics, high prevalence, and high mortality rates.

JAMA NEUROLOGY (2021)

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Review Infectious Diseases

Effectiveness and safety of SARS-CoV-2 vaccine in real-world studies: a systematic review and meta-analysis

Qiao Liu et al.

Summary: This study included 58 studies, with the effectiveness of a single dose vaccine in preventing SARS-CoV-2 infections at 41% and two doses reaching 85% effectiveness. The vaccines are generally safe and help reduce the incidence of COVID-19-related deaths and severe cases.

INFECTIOUS DISEASES OF POVERTY (2021)

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Review Infectious Diseases

Genetic polymorphisms as multi-biomarkers in severe acute respiratory syndrome (SARS) by coronavirus infection: A systematic review of candidate gene association studies

Ana Caroline Melo dos Santos et al.

Summary: This study conducted a systematic review on the impact of single nucleotide polymorphisms in the development of SARS, revealing multiple genetic polymorphisms associated with susceptibility or protection to SARS-CoV infection. Further research is needed to provide more concrete evidence, particularly related to Covid-19.

INFECTION GENETICS AND EVOLUTION (2021)

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Review Medicine, General & Internal

The Effect of Anakinra in Hospitalized Patients with COVID-19: An Updated Systematic Review and Meta-Analysis

Konstantinos G. Kyriakoulis et al.

Summary: Immunomodulatory agent anakinra has shown significant clinical benefits in treating hospitalized patients with COVID-19 and hyperinflammation. A recent systematic review and meta-analysis found that anakinra may have a beneficial role in the treatment of selected COVID-19 patients, although the evidence is mainly based on observational studies.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, General & Internal

Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine

Dimitrios A. Vrachatis et al.

Summary: The article discusses the epidemiology and clinical features of COVID-19, analyzing the importance of immune dysregulation and hypercoagulability in disease complications, and provides an up-to-date systematic review of colchicine's immunomodulating capacity in hindering coronavirus complications.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, General & Internal

The Spectrum of Manifestations of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV2) Infection in Children: What We Can Learn From Multisystem Inflammatory Syndrome in Children (MIS-C)

Salvatore Panaro et al.

Summary: Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe clinical condition that requires hospitalization and is often characterized by fever, multi-system organ dysfunction, and increased inflammatory biomarkers, with features such as myocarditis and shock. It typically occurs after the peak of adult COVID-19 cases, suggesting it is a post-infectious disease. MIS-C is considered a hyperinflammatory disease with different immunological features from acute SARS-CoV-2 infection, sharing similarities with other conditions like Macrophage Activation Syndrome (MAS) and Kawasaki Disease (KD).

FRONTIERS IN MEDICINE (2021)

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Article Medicine, General & Internal

Impact of the Addition of Baricitinib to Standard of Care Including Tocilizumab and Corticosteroids on Mortality and Safety in Severe COVID-19

Mar Masia et al.

Summary: The addition of baricitinib did not substantially reduce mortality in hospitalized patients with COVID-19 experiencing clinical progression despite tocilizumab and corticosteroid therapy, and it was not associated with an increased risk of secondary infections or thromboembolic events.

FRONTIERS IN MEDICINE (2021)

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Article Medicine, General & Internal

Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following BNT162b2 mRNA Vaccine Booster Shot: A Case Report

Serge Goldman et al.

Summary: Nucleoside-modified mRNA vaccines have a strong impact on T follicular helper cells, which may influence the development of neoplasms. This report discusses the unexpected rapid progression of lymphomatous lesions in a man diagnosed with AITL after receiving a BNT162b2 mRNA vaccine booster.

FRONTIERS IN MEDICINE (2021)

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Review Medicine, General & Internal

The Effectiveness of Convalescent Plasma for the Treatment of Novel Corona Virus Disease 2019: A Systematic Review and Meta-Analysis

Huiling Cao et al.

Summary: This meta-analysis study demonstrated that convalescent plasma has significant efficacy in reducing mortality and decreasing duration of mechanical ventilation for severe or critical COVID-19 patients. However, further research is needed to prove the safety of convalescent plasma.

FRONTIERS IN MEDICINE (2021)

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Review Public, Environmental & Occupational Health

Efficacy of COVID-19 Treatments: A Bayesian Network Meta-Analysis of Randomized Controlled Trials

Chenyang Zhang et al.

Summary: This network meta-analysis evaluated the efficacy of various treatments for COVID-19 compared to standard care, showing superiority in terms of mortality, mechanical ventilation, hospital discharge, and viral clearance. Tocilizumab was found to be particularly effective in preventing severe outcomes and increasing discharge rates. Additionally, the study highlighted the clinical efficacy of antineoplastic agents, immunostimulants, and immunosuppressants in reducing mortality, ventilation risk, and increasing discharge rates, providing valuable information for potential COVID-19 treatments.

FRONTIERS IN PUBLIC HEALTH (2021)

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Review Medicine, General & Internal

Comorbidities' potential impacts on severe and non-severe patients with COVID-19 A systematic review and meta-analysis

Sixiang Cheng et al.

Summary: Chronic comorbidities such as hypertension, diabetes, cardiovascular disease, cerebrovascular disease, and respiratory disease are associated with an increased risk of severe outcomes in patients with COVID-19. Old age and having two or more comorbidities significantly impact the outcomes of COVID-19 in hospitalized patients in China, according to the findings of this study.

MEDICINE (2021)

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Article Health Care Sciences & Services

Myocarditis and Pericarditis following COVID-19 Vaccination: Inequalities in Age and Vaccine Types

Minghui Li et al.

Summary: This study found that myocarditis and pericarditis following mRNA COVID-19 vaccines were rare but more common in adolescents and after the second dose. Both mRNA vaccines were significantly associated with increased risks for myocarditis/pericarditis, while the viral vector vaccine showed no associated signals.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Editorial Material Public, Environmental & Occupational Health

A pragmatic approach to COVID-19 vaccine passport

Ahmed Sharif et al.

BMJ GLOBAL HEALTH (2021)

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Editorial Material Medicine, General & Internal

Vaccine Passport Certification - Policy and Ethical Considerations

Mark A. Hall et al.

Summary: When considering vaccine passport certification, policymakers should take into account privileged activities and the identity of the regulator.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cell Biology

Predictors of Mortality in Critically Ill COVID-19 Patients Demanding High Oxygen Flow: A Thin Line between Inflammation, Cytokine Storm, and Coagulopathy

Viseslav Popadic et al.

Summary: In this study of 160 consecutive critically ill COVID-19 patients, IL-6, serum albumin, and D-dimer at ICU admission, along with CT severity score, were identified as independent predictors of mortality.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Rheumatology

Efficacy and safety of colchicine in COVID-19: a meta-analysis of randomised controlled trials

Kedar Gautambhai Mehta et al.

Summary: The meta-analysis findings suggest that the addition of colchicine to standard care regimen for patients with COVID-19 does not significantly reduce mortality, ventilatory support, ICU admission, length of hospital stay, or serious adverse events. There is a possibility of increased adverse events and diarrhea with colchicine treatment.

RMD OPEN (2021)

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Review Rheumatology

Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

Evdoxia Kyriazopoulou et al.

Summary: Anakinra may reduce mortality in hospitalized COVID-19 patients, particularly in those with signs of high inflammation, showing significant survival benefits.

LANCET RHEUMATOLOGY (2021)

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Article Pharmacology & Pharmacy

The association between the use of ivermectin and mortality in patients with COVID-19: a meta-analysis

Chia Siang Kow et al.

Summary: The meta-analysis showed a preliminary beneficial effect of ivermectin on mortality in patients with COVID-19, indicating the need for further large-scale randomized controlled trials to confirm these findings.

PHARMACOLOGICAL REPORTS (2021)

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Article Multidisciplinary Sciences

Evaluation of potential COVID-19 recurrence in patients with late repeat positive SARS-CoV-2 testing

Ithan D. Peltan et al.

Summary: Reinfection and reactivation of SARS-CoV-2 in COVID-19 patients have been mostly described in case reports. A study investigated the epidemiology of recurrent COVID-19 cases within a healthcare system from March to July 2020. Only 0.04% of all COVID-19 patients experienced probable or possible recurrence, indicating the majority of repeat positive tests were not actual recurrences. The combination of clinical and quantitative RT-PCR data proved to be valuable in aiding assessment of COVID-19 reinfection or reactivation by healthcare professionals.

PLOS ONE (2021)

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Article Cardiac & Cardiovascular Systems

Long-term prognosis following hospitalization for acute myocarditis - a matched nationwide cohort study

Muzhda Ghanizada et al.

Summary: Patients discharged alive following hospitalization for myocarditis, especially younger patients without prior cardiac disease, have a long-term excess risk of heart failure hospitalization and death, even in those who did not experience events or use heart failure medication one year after discharge. Data on long-term outcomes in patients with apparently uncomplicated myocarditis are sparse.

SCANDINAVIAN CARDIOVASCULAR JOURNAL (2021)

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Article Hematology

Brief report: Production of anti-SARS-CoV-2 hyperimmune globulin from convalescent plasma

Peter Vandeberg et al.

Summary: This study utilized convalescent plasma to manufacture anti-SARS-CoV-2 hyperimmune globulin (hIVIG) with high purity and concentrated antibody activity, potentially serving as an effective treatment for COVID-19.

TRANSFUSION (2021)

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Article Pharmacology & Pharmacy

Colchicine for the treatment of COVID-19 patients: efficacy, safety, and model informed dosage regimens

Eleni Karatza et al.

Summary: Colchicine is being investigated for cardioprotection in COVID-19 patients, with no consensus on the appropriate dosage regimen. Simulations indicated that 0.5 mg twice daily administration of colchicine can be considered safe and effective, tailored to patients' needs in cases of clearance impairment.

XENOBIOTICA (2021)

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Article Microbiology

Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma

Harini Natarajan et al.

Summary: This study analyzed convalescent plasma samples and found a diverse range of antiviral activity among recovered individuals. In addition to viral neutralization, convalescent plasma samples contained antibodies with various Fc-dependent functions, providing diversified resistance against SARS-CoV-2. Some eligible donors exhibited high activity in their plasma samples, which could be accurately identified as polyfunctional with even single Fc Array features.

MBIO (2021)

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Review Medicine, General & Internal

Prophylaxis against covid-19: living systematic review and network meta-analysis

Jessica J. Bartoszko et al.

Summary: Hydroxychloroquine prophylaxis has minimal effect on hospital admission and mortality, likely increases adverse effects, and probably does not reduce the risk of SARS-CoV-2 infection. The impact of ivermectin combined with iota-carrageenan and ivermectin alone on SARS-CoV-2 infection remains highly uncertain due to serious risk of bias and very serious imprecision.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Editorial Material Medicine, General & Internal

Covid-19 vaccine passports: access, equity, and ethics

Tasnime Osama et al.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Immunology

Impact of COVID-19 on Outpatient Antimicrobial Prescribing Patterns in New York City

Monica Douglas et al.

Summary: The study evaluated antimicrobial prescribing patterns in outpatient settings during the initial peak of COVID-19 in New York City, finding an overall increase in antimicrobial prescription rates, with drugs such as cefpodoxime, hydroxychloroquine, doxycycline, and sulfamethoxazole-trimethoprim being more commonly prescribed during this period.

INFECTIOUS DISEASES IN CLINICAL PRACTICE (2021)

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Article Cell Biology

Efficacy and safety of current medications for treating severe and non-severe COVID-19 patients: an updated network meta-analysis of randomized placebo-controlled trials

Qinglin Cheng et al.

Aging-US (2021)

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Review Pharmacology & Pharmacy

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines

Andrew Bryant et al.

Summary: The study shows that ivermectin treatment can significantly reduce COVID-19 mortality and potentially prevent disease progression. However, evidence for ivermectin chemoprophylaxis remains low certainty and requires further research.

AMERICAN JOURNAL OF THERAPEUTICS (2021)

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Article Surgery

Weak antibody response to three doses of mRNA vaccine in kidney transplant recipients treated with belatacept

Nathalie Chavarot et al.

Summary: Poor responses to mRNA COVID-19 vaccine were observed in kidney transplant recipients treated with belatacept, especially in those without prior COVID-19 history. However, patients with a history of COVID-19 developed a strong antibody response with high titers after vaccination. Further strategies are needed to improve protection in this population.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Health Care Sciences & Services

Estimating age-specific COVID-19 fatality risk and time to death by comparing population diagnosis and death patterns: Australian data

Ian C. Marschner

Summary: Deconvolution analysis can estimate age-specific mortality and time to death in COVID-19 patients, as demonstrated in a study conducted in Australia.

BMC MEDICAL RESEARCH METHODOLOGY (2021)

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Article Anesthesiology

Convalescent plasma for COVID-19: a meta-analysis, trial sequential analysis, and meta-regression

Timothy A. C. Snow et al.

Summary: The study found that convalescent plasma treatment did not show a clear mortality benefit in COVID-19 patients, and it did not prevent the need for mechanical ventilation or ICU admission in patients with mild disease.

BRITISH JOURNAL OF ANAESTHESIA (2021)

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Article Biochemistry & Molecular Biology

An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

Yafei Liu et al.

Summary: The research found that antibodies against different domains of the SARS-CoV-2 spike protein have different effects, with some antibodies inducing an open conformation of the RBD and enhancing the virus infectivity. Structural and mutational analysis revealed the mechanisms of these antibodies, and infectivity-enhancing antibodies were detected at higher levels in severe patients.

CELL (2021)

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Article Infectious Diseases

Rate and severity of suspected SARS-Cov-2 reinfection in a cohort of PCR-positive COVID-19 patients

Jeff Slezak et al.

Summary: Suspected reinfection with SARS-CoV-2 is uncommon, with a higher likelihood in women, adults, immunocompromised individuals, and those previously hospitalized for COVID-19. This suggests the importance of ongoing precautions and vaccination to prevent reinfection.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Review Critical Care Medicine

How trustworthy guidelines can impact outcomes

Bram Rochwerg et al.

Summary: Clinical practice guidelines can improve patient outcomes, and collaboration between organizations like the WHO has facilitated the rapid and reliable guidance during the COVID-19 pandemic, with new research providing new information on drugs for COVID-19.

CURRENT OPINION IN CRITICAL CARE (2021)

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Article Medicine, Research & Experimental

Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin

Guilherme Dias de Melo et al.

Summary: This study demonstrates that ivermectin can prevent clinical deterioration and reduce inflammation in the respiratory tracts of SARS-CoV-2-infected hamsters through immunomodulatory pathways, suggesting its potential to improve the clinical condition of patients infected with SARS-CoV-2.

EMBO MOLECULAR MEDICINE (2021)

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Article Medicine, General & Internal

CONVALESCENT plasma for COVID-19: A meta-analysis of clinical trials and real-world evidence

Chiraphat Kloypan et al.

Summary: Convalescent plasma treatment can reduce the risk of all-cause mortality in severe or critical COVID-19 patients. The study findings suggest that CP treatment is particularly effective in reducing mortality risk in patients with severe disease and when conducted in Asia.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Infectious Diseases

Low risk of reinfections and relation with serological response after recovery from the first wave of COVID-19

Maddalena Peghin et al.

Summary: This study found that reinfection after the first wave of COVID-19 was very uncommon in an unselected population after a prolonged observation period of 10 months. It mainly occurred in individuals with a previous history of mild infection and weak or absent serological response, presenting with mild or asymptomatic clinical symptoms.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 AMeta-analysis

Manu Shankar-Hari et al.

Summary: This study identified 27 clinical trials and found that the use of IL-6 antagonists was associated with lower 28-day all-cause mortality in patients hospitalized for COVID-19 compared to usual care or placebo. Different risk effects were observed between tocilizumab and sarilumab, increasing understanding of the treatment with these drugs.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Editorial Material Medicine, General & Internal

IL-6 Receptor Antagonist Therapy for Patients Hospitalized for COVID-19 Who, When, and How?

Michael A. Matthay et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Letter Health Care Sciences & Services

Increase in Outpatient Ivermectin Dispensing in the US During the COVID-19 Pandemic: A Cross-Sectional Analysis

Jennifer N. Lind et al.

JOURNAL OF GENERAL INTERNAL MEDICINE (2021)

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Article Gastroenterology & Hepatology

Analysis of antibody responses after COVID-19 vaccination in liver transplant recipients and those with chronic liver diseases

Paul J. Thuluvath et al.

Summary: The study found that 61% of liver transplant recipients and 24% of patients with liver disease had poor antibody responses after receiving the SARS-CoV-2 vaccine. Immunocompromised status, vaccination with a single dose of Johnson & Johnson vaccine, and use of 2 or more immunosuppressive medications were associated with poor immune responses.

JOURNAL OF HEPATOLOGY (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

Jackson S. Turner et al.

Summary: The study found that individuals who had recovered from mild SARS-CoV-2 infections showed rapid decline of serum anti-SARS-CoV-2 spike protein antibodies in the first 4 months after infection, followed by a more gradual decrease over the following 7 months but remaining detectable at least 11 months after infection. This suggests that mild infection with SARS-CoV-2 can induce robust antigen-specific, long-lived humoral immune memory in humans.

NATURE (2021)

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Article Biochemistry & Molecular Biology

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Evdoxia Kyriazopoulou et al.

Summary: The SAVE-MORE phase 3 study demonstrated the efficacy of anakinra, an IL-1 alpha/beta inhibitor, in patients with COVID-19 and high serum levels of soluble plasminogen activator receptor, showing significant reduction in clinical deterioration and decreased 28-day mortality.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia

Patricia O. Guimaraes et al.

Summary: Among patients hospitalized with Covid-19 pneumonia, tofacitinib led to a lower risk of death or respiratory failure through day 28 than placebo. The mortality rate was lower in the tofacitinib group within 28 days. However, the rate of serious adverse events was similar in both groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19

M. P. O'Brien et al.

Summary: The study indicates that subcutaneous REGEN-COV can effectively prevent severe Covid-19 and reduce the duration of symptoms in individuals at high risk for infection due to household exposure to confirmed SARS-CoV-2 cases.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Early Convalescent Plasma for High-Risk Outpatients with Covid-19

Frederick K. Korley et al.

Summary: This study showed that administering Covid-19 convalescent plasma to high-risk outpatients within 1 week after symptom onset did not prevent disease progression.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Obstetrics & Gynecology

The Role of Subcutaneous Depot Medroxyprogesterone Acetate in Equitable Contraceptive Care A Lesson From the Coronavirus Disease 2019 (COVID-19) Pandemic

Audrey M. Burlando et al.

Summary: The study reviews evidence on the acceptability, safety, and continuation rates of DMPA-subcutaneous, highlighting the disproportionate non-White population among Depot medroxyprogesterone acetate users and suggesting measures to promote the prescription of DMPA-subcutaneous injection.

OBSTETRICS AND GYNECOLOGY (2021)

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Article Cell Biology

Development and Validation of a Multivariable Predictive Model for Mortality of COVID-19 Patients Demanding High Oxygen Flow at Admission to ICU: AIDA Score

Marija Zdravkovic et al.

Summary: The AIDA score was found to be significant in estimating mortality risk among patients with severe COVID-19 disease at admission to ICU. Results from the validation cohort demonstrated high discriminative value of the model, categorizing patients into low and high-risk categories efficiently.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Virology

Immune characterization and profiles of SARS-CoV-2 infected patients reveals potential host therapeutic targets and SARS-CoV-2 oncogenesis mechanism

Martine Policard et al.

Summary: The urgent need for treatments to combat SARS-CoV-2 and the increasing mortality rates of COVID-19 highlight the significance of developing therapeutic strategies to address the current pandemic and potential future outbreaks. By studying the host immune response patterns, potential biomarkers and therapeutic targets can be identified to improve disease severity in COVID-19 patients.

VIRUS RESEARCH (2021)

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Review Public, Environmental & Occupational Health

Hydroxychloroquine and mortality in COVID-19 patients: a systematic review and a meta-analysis of observational studies and randomized controlled trials

Augusto Di Castelnuovo et al.

Summary: The study found that HCQ can reduce mortality in COVID-19 patients when used in lower doses, but the association is not significant in most cases. The use of HCQ+AZM may also reduce mortality risk, but more research is needed to confirm this.

PATHOGENS AND GLOBAL HEALTH (2021)

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Article Critical Care Medicine

Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial

Jurjan Aman et al.

Summary: The study showed that imatinib did not significantly reduce the time to discontinuation of oxygen in COVID-19 patients, but may improve survival rates and reduce the duration of invasive mechanical ventilation. Safety evaluation revealed no significant adverse events associated with imatinib.

LANCET RESPIRATORY MEDICINE (2021)

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Article Medicine, General & Internal

Evolution of antibody responses up to 13 months after SARS-CoV-2 infection and risk of reinfection

Floriane Gallais et al.

Summary: The study revealed a triphasic kinetic model of SARS-CoV-2 antibodies in convalescent individuals, showing long-term persistence and reduced risk of reinfection. Vaccination significantly increased antibody titers, enhancing protection against variants.

EBIOMEDICINE (2021)

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Article Oncology

Poor Neutralizing Antibody Responses in 132 Patients with CLL, NHL and HL after Vaccination against SARS-CoV-2: A Prospective Study

Evangelos Terpos et al.

Summary: The urgency of the COVID-19 pandemic has accelerated vaccine development, but patients with hematological malignancies show suboptimal immune response to the SARS-CoV-2 vaccine, highlighting the need for timely vaccination during a treatment-free period and continuous vigilance on infection control measures.

CANCERS (2021)

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Review Immunology

Antibody Responses to Natural SARS-CoV-2 Infection or after COVID-19 Vaccination

Haya Altawalah

Summary: The novel coronavirus, SARS-CoV-2, is the causative agent of COVID-19. The severity of the disease ranges from asymptomatic to critical, and it has been a global challenge since the first case in 2019, especially with the emergence of variants in 2021. Understanding immune response during COVID-19 and vaccination is crucial for managing the pandemic and optimizing vaccination strategies.

VACCINES (2021)

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Article Microbiology

Mild SARS-CoV-2 Illness Is Not Associated with Reinfections and Provides Persistent Spike, Nucleocapsid, and Virus-Neutralizing Antibodies

Charles F. Schuler et al.

Summary: This study demonstrates that individuals with mild COVID-19 who produce antibodies are protected from reinfection for up to 6 months. The antibodies produced in this situation remain stable for up to 6 months and correlate well with neutralization activity.

MICROBIOLOGY SPECTRUM (2021)

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Review Medicine, General & Internal

Convalescent Plasma Therapy for COVID-19: A Graphical Mosaic of the Worldwide Evidence

Stephen A. Klassen et al.

Summary: Global evidence suggests that convalescent plasma can improve COVID-19 patient survival, particularly when transfused early in the disease course. Randomized controlled trials have shown limited or no benefit when transfused later in the disease course. Convalescent plasma also contributes to improved symptomatology and viral clearance, and has a similar safety profile as standard plasma.

FRONTIERS IN MEDICINE (2021)

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Article Medicine, General & Internal

被撤回的出版物: Proxalutamide Reduces the Rate of Hospitalization for COVID-19 Male Outpatients: A Randomized Double-Blinded Placebo-Controlled Trial (Publication with Expression of Concern. See vol. 8, 2022) (Retracted article. See vol. 9, 2022)

John McCoy et al.

Summary: The use of proxalutamide as an androgen receptor antagonist in men with COVID-19 has shown to significantly reduce the hospitalization rate, with a 91% reduction compared to usual care.

FRONTIERS IN MEDICINE (2021)

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Review Medicine, General & Internal

Safety and Efficacy of Convalescent Plasma in COVID-19: An Overview of Systematic Reviews

Massimo Franchini et al.

Summary: This study aimed to summarize evidence on the efficacy and safety of convalescent plasma (CP) in treating COVID-19. Results showed a reduction in mortality with CP over standard therapy when administered early and at high titer, without increased adverse reactions, although there was variability in the certainty of the evidence.

DIAGNOSTICS (2021)

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Review Infectious Diseases

Systematic Review and Subgroup Meta-analysis of Randomized Trials to Determine Tocilizumab's Place in COVID-19 Pneumonia

Timothee Klopfenstein et al.

Summary: This study supports tocilizumab as an effective treatment in hospitalized patients with COVID-19, improving survival and reducing the need for mechanical ventilation. The greatest benefit of tocilizumab was observed in severe COVID-19 cases.

INFECTIOUS DISEASES AND THERAPY (2021)

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Review Biochemistry & Molecular Biology

Differential p53-Mediated Cellular Responses to DNA-Damaging Therapeutic Agents

Lindsey Carlsen et al.

Summary: The TP53 gene, encoding the tumor suppressor protein p53, is mutated in around 50% of cancers. After DNA damage, p53 acts as a transcription factor to activate target genes for cell fates such as apoptosis, cell cycle arrest, and DNA repair. The complex regulatory network controlling target gene selection by p53 varies across contexts such as treatment type, cell type, and tissue type.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Medicine, General & Internal

Vaccine-Associated Thrombocytopenia and Thrombosis: Venous Endotheliopathy Leading to Venous Combined Micro-Macrothrombosis

Jae C. Chang et al.

Summary: Vaccine-associated complications include ITP-like syndrome, multiorgan inflammatory syndrome, and CVST, all related to venous microthrombotic disease. Vaccine-induced thrombosis is more serious, requiring a combination therapy of complement inhibitor and anticoagulant.

MEDICINA-LITHUANIA (2021)

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Article Health Care Sciences & Services

Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study

Paul Naaber et al.

Summary: The study found that antibody levels declined at 12 weeks and 6 months after receiving two doses of BNT162b2 vaccine, with Spike antibody levels at 6 months being similar to those in individuals who received one dose or had recovered from COVID-19. Most individuals developed Spike-specific memory T cell responses, which were lower in those with higher T cell immunosenescence. Antibody response was negatively correlated with age and positively correlated with the total score of vaccination side effects.

LANCET REGIONAL HEALTH-EUROPE (2021)

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Review Immunology

A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies

Gabriela Athziri Sanchez-Zuno et al.

Summary: This article discusses the global public health emergency caused by the COVID-19 pandemic and the antibody-dependent enhancement phenomenon in vaccine development. Additionally, it explores the impact of ADE phenomenon in various viral infections and its limiting role in the development of new vaccines and treatment strategies.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Early combination therapy with hydroxychloroquine and azithromycin reduces mortality in 10,429 COVID-19 outpatients

Matthieu Million et al.

Summary: The study evaluated the age-specific mortality of adult outpatients infected with SARS-CoV-2 early treated in a dedicated COVID-19 day hospital, and found that the use of HCQ+AZ was associated with improved survival. Older age and male sex were identified as risk factors for death, ICU transfer, and hospitalization. The meta-analysis showed that early ambulatory treatment with HCQ+AZ is associated with very low mortality and better survival compared to other regimens.

REVIEWS IN CARDIOVASCULAR MEDICINE (2021)

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Article Medicine, General & Internal

Hyperimmune anti-COVID-19 IVIG (C-IVIG) treatment in severe and critical COVID-19 patients: A phase I/II randomized control trial

Shaukat Ali et al.

Summary: Hyperimmune anti-COVID-19 Intravenous Immunoglobulin (C-IVIG) therapy appears to be a safe and effective treatment for severe and critical COVID-19 patients, improving survival rates and reducing disease progression.

ECLINICALMEDICINE (2021)

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Letter Medicine, General & Internal

Long-term antibody-response monitoring following primary exposure to SARS-COV-2 and afterward mRNA COVID-19 vaccination: A case report

Bela Balint et al.

VOJNOSANITETSKI PREGLED (2021)

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Review Medicine, General & Internal

Does COVID-19 Vaccination Warrant the Classical Principle ofelein i mi vlaptin?

Michael Doulberis et al.

Summary: The article underscores the urgent issues in the development of COVID-19 vaccines, including the risks of rapid vaccine development and the effectiveness of vaccines against new variants. It calls for scientists and clinicians to pay attention to these issues for more comprehensive management.

MEDICINA-LITHUANIA (2021)

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Article Medicine, General & Internal

Proxalutamide Significantly Accelerates Viral Clearance and Reduces Time to Clinical Remission in Patients with Mild to Moderate COVID-19: Results from a Randomized, Double-Blinded, Placebo-Controlled Trial

Flavio A. Cadegiani et al.

Summary: Proxalutamide significantly accelerated viral clearance on Day 7 in mild to moderate COVID-19 patients compared to placebo. Additionally, the time to clinical remission was significantly reduced in patients treated with Proxalutamide compared to placebo.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Review Infectious Diseases

Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19

A. D. Santin et al.

Summary: The discovery of IVM has shown success in treating some of the most devastating diseases in the world and has demonstrated potential effectiveness in the treatment of COVID-19.

NEW MICROBES AND NEW INFECTIONS (2021)

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Letter Cell Biology

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Manli Wang et al.

CELL RESEARCH (2020)

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Letter Medicine, General & Internal

On the use of corticosteroids for 2019-nCoV pneumonia

Lianhan Shang et al.

LANCET (2020)

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Editorial Material Medicine, General & Internal

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

Clark D. Russell et al.

LANCET (2020)

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Editorial Material Infectious Diseases

COVID-19: combining antiviral and anti-inflammatory treatments

Justin Stebbing et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Critical Care Medicine

Risks of N95 Face Mask Use in Subjects With COPD

Sun Young Kyung et al.

RESPIRATORY CARE (2020)

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Review Pharmacology & Pharmacy

Of chloroquine and COVID-19

Franck Touret et al.

ANTIVIRAL RESEARCH (2020)

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Letter Immunology

Imatinib might constitute a treatment option for lung involvement in COVID-19

David Bernal-Bello et al.

AUTOIMMUNITY REVIEWS (2020)

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Review Immunology

Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Brescia, Italy

Paola Toniati et al.

AUTOIMMUNITY REVIEWS (2020)

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Article Immunology

Plasmapheresis treatment in COVID-19-related autoimmune meningoencephalitis: Case series

Lerzan Dogan et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

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Article Oncology

RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers

John J. Krais et al.

CANCER RESEARCH (2020)

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Article Immunology

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Xueting Yao et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Article Respiratory System

Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis

Wei-jie Guan et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Article Infectious Diseases

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

Philippe Gautret et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

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Article Endocrinology & Metabolism

Colchicine's effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial

Andrew P. Demidowich et al.

INTERNATIONAL JOURNAL OF OBESITY (2020)

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Article Allergy

Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

Tobias Herold et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Letter Infectious Diseases

Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact

Fabrizio Cantini et al.

JOURNAL OF INFECTION (2020)

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Review Pediatrics

Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)

Kun-Ling Shen et al.

WORLD JOURNAL OF PEDIATRICS (2020)

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Article Multidisciplinary Sciences

A human monoclonal antibody blocking SARS-CoV-2 infection

Chunyan Wang et al.

NATURE COMMUNICATIONS (2020)

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Editorial Material Medicine, General & Internal

Face masks for the public during the covid-19 crisis

Trisha Greenhalgh et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Letter Medicine, General & Internal

Covid-19: Important potential side effects of wearing face masks that we should bear in mind

Antonio Ivan Lazzarino et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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News Item Medicine, General & Internal

Covid-19: FDA approves use of convalescent plasma to treat critically ill patients

Janice Hopkins Tanne

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Medicine, General & Internal

Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

Mandeep R Mehra et al.

LANCET (2020)

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Article Medicine, General & Internal

Hyperinflammatory shock in children during COVID-19 pandemic

Shelley Riphagen et al.

LANCET (2020)

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Letter Infectious Diseases

Baricitinib for COVID-19: a suitable treatment?

Ennio G. Favalli et al.

LANCET INFECTIOUS DISEASES (2020)

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Review Public, Environmental & Occupational Health

Coronavirus disease 2019 (COVID-19): A literature review

Harapan Harapan et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2020)

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Review Chemistry, Multidisciplinary

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

Richard T. Eastman et al.

ACS CENTRAL SCIENCE (2020)

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Review Medicine, General & Internal

Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development

Ruklanthi de Alwis et al.

EBIOMEDICINE (2020)

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Letter Cell Biology

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

Jia Liu et al.

CELL DISCOVERY (2020)

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Article Medicine, General & Internal

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

Jason D. Goldman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Medicine, General & Internal

Children with Covid-19 in Pediatric Emergency Departments in Italy

Niccolo Parri et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Medicine, General & Internal

SARS-CoV-2 Infection in Children

Xiaoxia Lu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Compassionate Use of Remdesivir for Patients with Severe Covid-19

J. Grein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Pharmacology & Pharmacy

Molecular immune pathogenesis and diagnosis of COVID-19

Xiaowei Li et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2020)

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Letter Rheumatology

Colchicine as a possible therapeutic option in COVID-19 infection

Rafael Parra-Medina et al.

CLINICAL RHEUMATOLOGY (2020)

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Article Pharmacology & Pharmacy

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Leon Caly et al.

ANTIVIRAL RESEARCH (2020)

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Article Dermatology

Topical recombinant human acidic fibroblast growth factor: An effective therapeutic agent for facemask wearing-induced pressure sores

Pan Luo et al.

DERMATOLOGIC THERAPY (2020)

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Article Rheumatology

Use of Anakinra to Prevent Mechanical Ventilation in Severe COVID-19: A Case Series

Iris Navarro-Millan et al.

ARTHRITIS & RHEUMATOLOGY (2020)

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Review Pharmacology & Pharmacy

Pharmacological and non-pharmacological efforts at prevention, mitigation, and treatment for COVID-19

Mohammed M. Alvi et al.

JOURNAL OF DRUG TARGETING (2020)

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Letter Medicine, General & Internal

Changes in the Number of US Patients With Newly Identified Cancer Before and During the Coronavirus Disease 2019 (COVID-19) Pandemic

Harvey W. Kaufman et al.

JAMA NETWORK OPEN (2020)

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Article Medicine, General & Internal

Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019 The GRECCO-19 Randomized Clinical Trial

Spyridon G. Deftereos et al.

JAMA NETWORK OPEN (2020)

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Letter Infectious Diseases

Beneficial impact of Baricitinib in COVID-19 moderate pneumonia; multicentre study

Fabrizio Cantini et al.

JOURNAL OF INFECTION (2020)

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Review Psychology, Developmental

Rapid Systematic Review: The Impact of Social Isolation and Loneliness on the Mental Health of Children and Adolescents in the Context of COVID-19

Maria Elizabeth Loades et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2020)

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Editorial Material Multidisciplinary Sciences

Women are most affected by pandemics - lessons from past outbreaks

Clare Wenham et al.

NATURE (2020)

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News Item Biotechnology & Applied Microbiology

Focus shifts to antibody cocktails for COVID-19 cytokine storm

Charlotte Harrison

NATURE BIOTECHNOLOGY (2020)

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Review Medicine, General & Internal

The impact of the COVID-19 pandemic on suicide rates

Leo Sher

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Charities that fund research face deep revenue declines

Eli Cahan

SCIENCE (2020)

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Editorial Material Medicine, General & Internal

Should governments continue lockdown to slow the spread of covid-19?

Edward R. Melnick et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Medicine, General & Internal

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-analysis

Jonathan A. C. Sterne et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 A Randomized Clinical Trial

Christoph D. Spinner et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Biochemistry & Molecular Biology

An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

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Letter Medicine, General & Internal

Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations

Eloise Baudou et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

Edward E. Walsh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

John H. Stone et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Public, Environmental & Occupational Health

Negative impacts of COVID-19 lockdown on mental health service access and follow-up adherence for immigrants and individuals in socio-economic difficulties

M. Aragona et al.

PUBLIC HEALTH (2020)

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Letter Surgery

Dexamethasone to combat cytokine storm in COVID-19: Clinical trials and preliminary evidence

Khan Sharun et al.

INTERNATIONAL JOURNAL OF SURGERY (2020)

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Article Pharmacology & Pharmacy

Therapeutic potential of ivermectin as add on treatment in COVID 19: A systematic review and meta-analysis

Biswa Mohan Padhy et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2020)

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Review Hematology

Potential of therapeutic plasmapheresis in treatment of COVID-19 patients: Immunopathogenesis and coagulopathy

Sahar Balagholi et al.

TRANSFUSION AND APHERESIS SCIENCE (2020)

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Article Multidisciplinary Sciences

Rapid and complete inactivation of SARS-CoV-2 by ultraviolet-C irradiation

Nadia Storm et al.

SCIENTIFIC REPORTS (2020)

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Article Critical Care Medicine

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

Emma J. Kooistra et al.

CRITICAL CARE (2020)

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Article Multidisciplinary Sciences

Age-specific mortality and immunity patterns of SARS-CoV-2

Megan O'Driscoll et al.

NATURE (2020)

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Article Infectious Diseases

Clinical efficacy of chloroquine derivatives in COVID-19 infection: comparative meta-analysis between the big data and the real world

M. Million et al.

NEW MICROBES AND NEW INFECTIONS (2020)

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Review Immunology

Drug repurposing and cytokine management in response to COVID-19: A review

Luana Heimfarth et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Infectious Diseases

COVID-19 and multisystem inflammatory syndrome in children and adolescents

Li Jiang et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Rheumatology

Anakinra for severe forms of COVID-19: a cohort study

Thomas Huet et al.

LANCET RHEUMATOLOGY (2020)

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Article Rheumatology

Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study

Giulio Cavalli et al.

LANCET RHEUMATOLOGY (2020)

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Review Immunology

Macrophage activation syndrome and COVID-19

Ryo Otsuka et al.

INFLAMMATION AND REGENERATION (2020)

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Letter Critical Care Medicine

Plasma exchange in critically ill COVID-19 patients

Christian Morath et al.

CRITICAL CARE (2020)

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Review Rheumatology

Adverse events during oral colchicine use: a systematic review and meta-analysis of randomised controlled trials

Sarah Stewart et al.

ARTHRITIS RESEARCH & THERAPY (2020)

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Review Immunology

How COVID-19 induces cytokine storm with high mortality

Shintaro Hojyo et al.

INFLAMMATION AND REGENERATION (2020)

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Review Medicine, General & Internal

Update on the diagnosis and management of COVID-19 in pediatric patients

Ana Paula de Carvalho Panzeri Carlotti et al.

CLINICS (2020)

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Article Rheumatology

Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study

Noa Biran et al.

LANCET RHEUMATOLOGY (2020)

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Article Rheumatology

Safety Profile of Baricitinib in Patients with Active Rheumatoid Arthritis with over 2 Years Median Time in Treatment

Josef S. Smolen et al.

JOURNAL OF RHEUMATOLOGY (2019)

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Review Immunology

Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses

Matthew Zirui Tay et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Rheumatology

Hydroxychloroquine: balancing the need to maintain therapeutic levels with ocular safety: an update

Nada Abdulaziz et al.

CURRENT OPINION IN RHEUMATOLOGY (2018)

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Article Pathology

TP53 mutations in peripheral mature T and NK cell lymphomas: a whole-exome sequencing study with correlation to p53 expression

Hui-Shan Huang et al.

HUMAN PATHOLOGY (2018)

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Review Physiology

Mitochondria, Oxidative Stress and Innate Immunity

Yuxin Chen et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Review Rheumatology

Interleukin-1 function and role in rheumatic disease

Georg Schett et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

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Article Virology

Hydroxychloroquine augments early virological response to pegylated interferon plus ribavirin in genotype-4 chronic hepatitis C patients

Gouda Kamel Helal et al.

JOURNAL OF MEDICAL VIROLOGY (2016)

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Review Biochemistry & Molecular Biology

Targeting the RB-E2F pathway in breast cancer

J. Johnson et al.

ONCOGENE (2016)

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Review Immunology

The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

L. A. Borthwick

SEMINARS IN IMMUNOPATHOLOGY (2016)

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Review Infectious Diseases

The enigma of the clandestine association between chloroquine and HIV-1 infection

A. Chauhan et al.

HIV MEDICINE (2015)

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Article Gastroenterology & Hepatology

Long-Term T-Cell-Mediated Immunologic Memory to Hepatitis B Vaccine in Young Adults Following Neonatal Vaccination

Hiva Saffar et al.

HEPATITIS MONTHLY (2014)

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Article Immunology

Critical Role for the NLRP3 Inflammasome during Acute Lung Injury

Jamison J. Grailer et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Virology

Coronavirus virulence genes with main focus on SARS-CoV envelope gene

Marta L. De Diego et al.

VIRUS RESEARCH (2014)

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Article Cell Biology

Technical Advance: Inhibition of neutrophil chemotaxis by colchicine is modulated through viscoelastic properties of subcellular compartments

Stephan Paschke et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2013)

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Article Virology

CD4 T-Cell Memory Responses to Viral Infections of Humans Show Pronounced Immunodominance Independent of Duration or Viral Persistence

Lichen Jing et al.

JOURNAL OF VIROLOGY (2013)

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Review Cell Biology

Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets-An Updated View

Wibke Schulte et al.

MEDIATORS OF INFLAMMATION (2013)

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Review Allergy

Hydroxychloroquine: From Malaria to Autoimmunity

Ilan Ben-Zvi et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2012)

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Review Public, Environmental & Occupational Health

Losing life and livelihood: A systematic review and meta-analysis of unemployment and all-cause mortality

David J. Roelfs et al.

SOCIAL SCIENCE & MEDICINE (2011)

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Review Toxicology

Colchicine poisoning: the dark side of an ancient drug

Yaron Finkelstein et al.

CLINICAL TOXICOLOGY (2010)

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Review Surgery

New aspects of Helicobacter pylori infection involvement in gastric oncogenesis

Jannis Kountouras et al.

JOURNAL OF SURGICAL RESEARCH (2008)

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Article Medicine, General & Internal

Nonpharmaceutical interventions implemented by US cities during the 1918-1919 influenza pandemic

Howard Markel et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2007)

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Article Virology

The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein

M Spiegel et al.

JOURNAL OF CLINICAL VIROLOGY (2004)

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