期刊
CHEMICAL SOCIETY REVIEWS
卷 51, 期 6, 页码 2171-2223出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cs00556a
关键词
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资金
- University of Rome Tor Vergata [E84I20000250005]
Direct functionalization of C(sp(3))-H bonds is a key focus in developing new synthetic methods. Among intermolecular C-H bond functionalization strategies, hydrogen atom transfer (HAT) methods using radical or radical-like reagents have gained increasing attention due to their ability to introduce a variety of atoms and groups in mild conditions. Selectivity control over aliphatic C-H bonds is crucial and factors influencing it have been discussed. This review article provides a detailed description of HAT reagents, associated mechanistic features, and selectivity patterns observed in the functionalization of increasingly complex substrates, based on an analysis of recent literature.
The direct functionalization of C(sp(3))-H bonds represents one of the most investigated approaches to develop new synthetic methodology. Among the available strategies for intermolecular C-H bond functionalization, increasing attention has been devoted to hydrogen atom transfer (HAT) based procedures promoted by radical or radical-like reagents, that offer the opportunity to introduce a large variety of atoms and groups in place of hydrogen under mild conditions. Because of the large number of aliphatic C-H bonds displayed by organic molecules, in these processes control over site-selectivity represents a crucial issue, and the associated factors have been discussed. In this review article, attention will be devoted to the role of electronic effects on C(sp(3))-H bond functionalization site-selectivity. Through an analysis of the recent literature, a detailed description of the HAT reagents employed in these processes, the associated mechanistic features and the selectivity patterns observed in the functionalization of substrates of increasing structural complexity will be provided.
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