期刊
NATURE MICROBIOLOGY
卷 2, 期 2, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmicrobiol.2016.238
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资金
- European Research Council [ERC-2009-AdG-249793]
- UK Medical Research Council [MR/M026663/1, G0400284]
- UK Biotechnology and Biological Research Council [BB/K017365/1, BB/M014525/1]
- Wellcome Trust [080088, 097377, 102705, 086827, 075470, 101873]
- CNPq-Brazil [202976/2014-9]
- UK National Centre for the Replacement, Refinement and Reduction of Animals in Research [NC/K000306/1]
- Medical Mycology and Fungal Immunology [097377]
- MRC Centre for Medical Mycology
- Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology [097377]
- University of Aberdeen [MR/N006364/1]
- UK Home Office [PPL 60/4135]
- Biotechnology and Biological Sciences Research Council [BB/K017365/1, BB/M012360/1] Funding Source: researchfish
- Medical Research Council [G0400284, MR/N006364/1, MR/M026663/1] Funding Source: researchfish
- Wellcome Trust [097377/Z/11/Z, 102705/Z/13/Z] Funding Source: researchfish
- BBSRC [BB/K017365/1, BB/M012360/1] Funding Source: UKRI
- MRC [MR/M026663/1, MR/N006364/1, G0400284] Funding Source: UKRI
As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of the innate immune response, and yet the commensal fungus Candida albicans is able to colonize immuno competent individuals. We show that C. albicans may evade immune detection by presenting a moving immunological target. We report that the exposure of beta-glucan, a key pathogen-associated molecular pattern (PAMP) located at the cell surface of C. albicans and other pathogenic Candida species, is modulated in response to changes in the carbon source. Exposure to lactate induces beta-glucan masking in C. albicans via a signalling pathway that has recruited an evolutionarily conserved receptor (Gpr1) and transcriptional factor (Crz1) from other well-characterized pathways. In response to lactate, these regulators control the expression of cell-wall-related genes that contribute to beta-glucan masking. This represents the first description of active PAMP masking by a Candida species, a process that reduces the visibility of the fungus to the immune system.
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