4.4 Review

Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Baicalin suppresses neuron autophagy and apoptosis by regulating astrocyte polarization in pentylenetetrazol-induced epileptic rats and PC12 cells

Ganggang Li et al.

Summary: The study aimed to explore the antiepileptic effect of baicalin. Results showed that baicalin reduced inflammation, improved behavior, and decreased seizures in rats by suppressing astrocyte autophagy and apoptosis. These findings suggest potential therapeutic effects of baicalin in epilepsy treatment.

BRAIN RESEARCH (2022)

Article Rehabilitation

How do people with Motor Neurone Disease experience dysphagia? A qualitative investigation of personal experiences

Dominika Lisiecka et al.

Summary: The study found that the experiences of dysphagia were closely intertwined with the overall disease experience of Motor Neurone Disease patients, who often had a changed perception of food and fear of choking. While they typically managed dysphagia independently, they also employed strategies such as choosing easy to swallow foods and limiting mealtime distractions.

DISABILITY AND REHABILITATION (2021)

Article Biochemistry & Molecular Biology

Design, synthesis and evaluation of new chromone-derived aminophosphonates as potential acetylcholinesterase inhibitor

Sarfaraz Shaikh et al.

Summary: By synthesizing novel N-substituted alpha-aminophosphonates bearing chromone moiety, we identified a compound with the best inhibitory effect on AChE, while a different category of compound showed better activity on BuChE. In terms of antioxidant properties and DNA protection, compound 4j exhibited significant activity.

MOLECULAR DIVERSITY (2021)

Review Neurosciences

The application ofin vitro-derived human neurons in neurodegenerative disease modeling

Gary X. D'Souza et al.

Summary: Developing safe and effective treatments for age-associated neurodegenerative disorders is a continuing challenge in the scientific community. The key lies in selecting appropriate modeling systems and overcoming challenges such as the complexity of the human brain and genetic/environmental contributions. While traditional rodent models have advanced our understanding of neurodegenerative diseases, limitations such as species-specific genetic backgrounds can restrict their application.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

Review Chemistry, Medicinal

An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins

Hari Madhav et al.

Summary: Malaria is an endemic disease prevalent in tropical and subtropical regions, with current therapeutic efforts being insufficient due to drug resistance, lack of vaccine availability, and absence of new mechanism drugs. Recent intensification of antimalarial research has led to the development of single dose multistage therapeutic agents to overcome drug resistance. The review explores progress in developing new promising antimalarials against target proteins with potential for clinical use, along with highlighting drug resistance aspects and new drug candidates.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Scaffold Hopping of α-Rubromycin Enables Direct Access to FDA-Approved Cromoglicic Acid as a SARS-CoV-2 MPro Inhibitor

Hani A. Alhadrami et al.

Summary: The study identified an antibiotic alpha-rubromycin from microbial natural products that can inhibit the viral key enzyme M-Pro but showed high cytotoxicity. By utilizing computational tools, a new pharmacophore was proposed to improve drug-like properties and reduce toxicity.

PHARMACEUTICALS (2021)

Review Biology

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Irshad Ul Haq Bhat et al.

Summary: Quercetin plays a critical role in cardiovascular and neuroprotective diseases, with extensive research supporting its bioactivities and therapeutic potential. Utilizing industrial food wastes/byproducts as a new source for bioactive compounds like quercetin is becoming a trend due to growing population and demand for fresh produce. The findings suggest quercetin as a reliable candidate for treating cardiovascular and neurological diseases, emphasizing its importance as a potential therapeutic agent for future research and development.

BIOLOGY-BASEL (2021)

Review Clinical Neurology

Diagnosis and Management of Seizures in Neurodegenerative Diseases

G. Adan et al.

Summary: This critical review examines epileptic seizures in common neurodegenerative diseases related to proteinopathy, such as Alzheimer's disease, and highlights the increased risk of seizures in AD patients. While evidence for anti-epileptic drug treatment in AD is weak, seizures may be associated with more rapid cognitive decline. The hope for the future is that disease-modifying treatments targeting aberrant protein species may also benefit seizure management.

CURRENT TREATMENT OPTIONS IN NEUROLOGY (2021)

Article Chemistry, Medicinal

Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-a]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies

Killian Oukoloff et al.

Summary: Triazolopyrimidines compounds show potential in treating Alzheimer's disease and neurodegenerative tauopathies, with the fragment at C6 playing a critical role in determining MT stability and integrity in cells. A new set of structurally modified analogues has been designed, synthesized, and evaluated, showing improved properties, activity, and pharmacokinetics compared to existing lead compounds.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease

Dan Li et al.

Summary: Amyloid aggregation disrupts protein homeostasis in neurodegenerative diseases. The structural diversity is crucial to amyloid pathology, with chemical modifications playing a key role in the formation of stable structures. Research aims to highlight the importance of these modifications in amyloid assembly and pathology.

NATURE CHEMICAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Neuroprotective compounds from the resinous heartwood of Aquilaria sinensis

Qian He et al.

Summary: Six previously unknown compounds were isolated from the resinous heartwood of Aquilaria sinensis, along with 15 known compounds. Structural and configurational analyses were performed on these compounds, some of which showed neuroprotective activities in PC12 cell models.

PHYTOCHEMISTRY (2021)

Article Pharmacology & Pharmacy

Chromone-lipoic acid conjugate: Neuroprotective agent having acceptable butyrylcholinesterase inhibition, antioxidant and copper-chelation activities

Leili Jalili-Baleh et al.

Summary: Novel chromone-lipoic acid hybrids were prepared and evaluated for their neuroprotection and anticholinesterase activity. Compound 19 showed the most potent butyrylcholinesterase inhibition and significant neuroprotection, making it a hopeful multifunctional agent in the treatment of Alzheimer's disease.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models

Lindsay McMurray et al.

Summary: Aggregated tau protein is a core pathology in neurodegenerative diseases, and PET imaging radiotracers that bind to tau fibrils are important for understanding these disorders. The compound LM229 from a novel library based on PBB3 backbone shows high affinity and specificity for tau aggregates in various animal models and human brain sections. LM229 can also cross the blood-brain barrier and be effectively radiolabeled with carbon-11, making it a promising tool for PET translational studies using rodent transgenic tau models.

ACS CHEMICAL NEUROSCIENCE (2021)

Article Chemistry, Medicinal

Synthesis of novel isoflavone/benzo-δ-sultam hybrids as potential anti-inflammatory drugs

Gabriel Mengheres et al.

Summary: A series of novel isoflavone/benzo-o-sultam hybrids were synthesized and evaluated for their potential anti-inflammatory and neuroprotective effects in LPS-activated BV2 microglia. The most potent hybrid compound showed promising results by reducing NO production to 41% and TNF-alpha to 34% in the cells.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

Review Chemistry, Multidisciplinary

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Phuong H. Nguyen et al.

Summary: Protein misfolding and aggregation are common in amyloidogenic diseases, and understanding how amyloid species become toxic is crucial for treatment development. Experiments using computer modeling, in vitro and in vivo studies, as well as pharmacology, have provided valuable insights into the accumulation and deposition of amyloid species, contributing to research on diseases like Alzheimer's, Parkinson's, diabetes, and ALS.

CHEMICAL REVIEWS (2021)

Article Chemistry, Physical

A chromone based Schiff base: An efficient colorimetric sensor for specific detection of Cu (II) ion in real water samples

Nisha Tomer et al.

Summary: A new chromone based Schiff base ligand L was synthesized and successfully used as a colorimetric probe for selectively detecting Cu (II) ions, showing instant visual color change and high sensitivity. The ligand L exhibited a binding stoichiometry of 1:1 with Cu2+ ions, and demonstrated strong selectivity and effectiveness in identifying and quantifying Cu2+ ions in real water samples.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Review Neurosciences

RNA transport and local translation in neurodevelopmental and neurodegenerative disease

Michael S. Fernandopulle et al.

Summary: The RNA transport apparatus in neurons plays a crucial role in local protein synthesis, and its dysfunction is implicated in various neurodegenerative diseases. This mechanism serves as a unifying pathomechanism for neurodegenerative diseases, highlighting the importance of understanding altered RNA transport and local translation in neuronal diseases.

NATURE NEUROSCIENCE (2021)

Article Neurosciences

Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

Ramita Dewan et al.

Summary: Researchers analyzed whole-genome sequence data from 2,442 FTD/ALS patients, 2,599 LBD patients, and 3,158 neurologically healthy subjects, identifying pathogenic HTT gene expansions in a small percentage of FTD/ALS patients but not in the LBD or healthy groups. Postmortem evaluations supported an etiological relationship between HTT repeat expansions and FTD/ALS syndromes, suggesting the importance of genetic screening for HTT repeat expansions in FTD/ALS patients.

NEURON (2021)

Article Medicine, General & Internal

Donanemab in Early Alzheimer's Disease

Mark A. Mintun et al.

Summary: In this study, donanemab showed improved composite scores for cognition and daily living activities compared to placebo in patients with early Alzheimer's disease at 76 weeks, although secondary outcomes varied. Longer and larger trials are needed to further explore the efficacy and safety of donanemab in Alzheimer's disease.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Biology

Diaportheone A Analogues Instigate a Neuroprotective Effect by Protecting Neuroblastoma SH-SY5Y Cells from Oxidative Stress

Mario A. Tan et al.

Summary: Alzheimer's disease is a progressive neurodegenerative illness affecting mainly elderly individuals, and the compounds Diaportheones A1 and A2 may have potential therapeutic effects against this disease.

BIOLOGY-BASEL (2021)

Article Biochemistry & Molecular Biology

Chromone derivatives bearing pyridinium moiety as multi-target-directed ligands against Alzheimer's disease

Shahin Abdpour et al.

Summary: A new series of 7-hydroxy-chromone derivatives bearing pyridine moiety were synthesized and evaluated as multifunctional agents against Alzheimer's disease (AD). Compounds 14 and 10 showed the best inhibitory activity towards AChE and BuChE, with good neuroprotective activity and ability to effectively block A? aggregation.

BIOORGANIC CHEMISTRY (2021)

Article Chemistry, Medicinal

Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer's action: Design, synthesis, crystal structure and in-vitro biological evaluation

Shoaib Manzoor et al.

Summary: This study designed and synthesized a series of novel multitarget-directed ligand compounds for the treatment of Alzheimer's disease (AD). These compounds exhibited significant inhibitory activity against neural enzymes in vitro, potentially serving as promising candidate drugs for the treatment of AD.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Chromeno[3,4-b]xanthones as First-in-Class AChE and Aβ Aggregation Dual-Inhibitors

Daniela Malafaia et al.

Summary: Alzheimer's disease is a complex multifactorial disorder characterized by the progressive loss of memory and cognitive, motor, and functional capacity. This study describes the design, synthesis, and biological evaluation of a family of compounds as first-in-class acetylcholinesterase and beta-amyloid aggregation dual-inhibitors, offering potential for the development of new multitarget compounds for AD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Chemistry, Medicinal

Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection

Qi Li et al.

Summary: S06-1011 and S06-1031 are highly effective and selective BChE inhibitors that improve cognition and have neuroprotective effects, also showing positive effects on improving mental status and appetite.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Plant Sciences

Total Synthesis of the Neuroprotective Agent Cudraisoflavone J

Qili Lu et al.

Summary: The study presents the total synthesis of the neuroprotective compound cudraisoflavone J from Cudrania tricuspidata, isolating two enantiomers using kinetic resolution. The absolute configuration of naturally occurring cudraisoflavone J was elucidated using a modified Mosher's method.

JOURNAL OF NATURAL PRODUCTS (2021)

Article Clinical Neurology

Regional Brain and Spinal Cord Volume Loss in Spinocerebellar Ataxia Type 3

Jennifer Faber et al.

Summary: The study aimed to quantify regional brain volumes and cervical spinal cord areas in spinocerebellar ataxia type 3 patients using MRI, revealing that tissue loss in the brain and spinal cord starts before ataxia onset in early-stage patients. Pontine volume is identified as a potential imaging biomarker candidate for intervention trials aiming to slow the progression of the disease.

MOVEMENT DISORDERS (2021)

Article Behavioral Sciences

Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway

Zhixia Jia et al.

Summary: The study demonstrated that baicalin can improve cognitive functions and has antidepressant effects in mice, potentially through the activation of the BDNF/ERK/CREB signaling pathway in the hippocampus.

BEHAVIOURAL BRAIN RESEARCH (2021)

Article Pharmacology & Pharmacy

Baicalin promotes hippocampal neurogenesis via the Wnt/β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression

Zhigang Xiao et al.

Summary: Baicalin may promote hippocampal neurogenesis and alleviate depression-like behaviors induced by chronic mild unpredictable stress through regulation of the Wnt/beta-catenin signaling pathway.

BIOCHEMICAL PHARMACOLOGY (2021)

Article Chemistry, Medicinal

Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease

Hong Yao et al.

Summary: A series of novel tacrine-pyrimidone hybrids showed significant inhibitory activities against AChE and GSK-3. The optimal compound 27g exhibited dual AChE/GSK-3 inhibition, cognitive improvement, and neuroprotection, making it a promising lead for AD treatment.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats

Jiali Yang et al.

Summary: This study evaluated the beneficial effects of baicalin (BA) on cognitive dysfunction and neurodegeneration in PTZ-induced epileptic rats. Results showed that BA had anti-epileptic effects, improved cognitive dysfunction, and mitigated neurodegeneration in the hippocampus CA3 regions of epileptic rats. The potential mechanism of BA's anti-epileptic effects may involve the activation of the TLR4/MYD88/Caspase-3 pathway.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Article Biochemistry & Molecular Biology

Studies on the affinity of 6-[(n-(cyclo)aminoalkyl)oxy]-4H-chromen-4-ones for sigma 1/2 receptors

Winnie Deuther-Conrad et al.

Summary: The study identified chromenones as new sigma 1/sigma 2 ligands with potential dual-target activities against acetylcholinesterase and monoamine oxidase B. Several compounds showed affinity for sigma 1 receptor and demonstrated inhibitory capacity against cholinesterases, suggesting therapeutic potential for treating disorders like Alzheimer's disease and neuropathic pain.

RSC MEDICINAL CHEMISTRY (2021)

Article Chemistry, Organic

Unravelling the potency of triazole analogues for inhibiting α-synuclein fibrillogenesis and in vitro disaggregation

Mudasir Maqbool et al.

Summary: A series of triazole-based compounds were synthesized and evaluated for their inhibitory effects on alpha-synuclein fibrillogenesis and disaggregation. The compounds showed good binding interactions with alpha-syn and had no toxic effects on cells, indicating potential as therapeutic interventions for synucleinopathies such as Parkinson's disease and Lewy body dementia.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

Article Multidisciplinary Sciences

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases

Martin Trapecar et al.

Summary: The research has developed a mesofluidic platform technology to study gut-liver-cerebral interactions, aiming to explore the pathophysiology of neurodegenerative diseases. Experimental results using a patient-derived Parkinson's disease brain model show that systemic interactions and microbiome-associated short-chain fatty acids are related to pathology-associated pathways in PD.

SCIENCE ADVANCES (2021)

Article Chemistry, Multidisciplinary

Design and synthesis of novel benzyloxy-tethered-chromone-carboxamide derivatives as potent and selective human monoamine oxidase-b inhibitors

Y. Jayaprakash Rao et al.

Summary: A series of new bifunctional chromone carboxamides were synthesized and evaluated for their inhibitory activity against human monoamine oxidase. Two compounds showed higher potency against MAO-B compared to the standard inhibitor, with high selectivity. The docking results suggest positive interactions with hMAO-B and repulsive interactions with hMAO-A, confirming the selectivity of these compounds towards MAO-B.

CHEMICAL PAPERS (2021)

Review Biochemistry & Molecular Biology

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

James W. Fawcett

NEUROCHEMICAL RESEARCH (2020)

Article Chemistry, Medicinal

Synthesis and evaluation of chromone-2-carboxamido-alkylamines as potent acetylcholinesterase inhibitors

Paptawan Suwanhom et al.

MEDICINAL CHEMISTRY RESEARCH (2020)

Review Pharmacology & Pharmacy

Anti-amyloid-beta protein agents for the treatment of Alzheimer's disease: an update on emerging drugs

Madia Lozupone et al.

EXPERT OPINION ON EMERGING DRUGS (2020)

Article Pharmacology & Pharmacy

Repositioning Chromones for Early Anti-inflammatory Treatment of COVID-19

Piero Sestili et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Chemistry, Multidisciplinary

Synthesis of Novel Functionalized Pyrano Annulated/Oxazolone Pendent Chromone Derivatives as Potent Anti-Diabetic Agents

Y. Jayaprakash Rao et al.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY (2020)

Article Chemistry, Medicinal

Diphenyl triazine hybrids inhibit α-synuclein fibrillogenesis: Design, synthesis and in vitro efficacy studies

Mudasir Maqbool et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Chemistry, Medicinal

Syntheses and Evaluation of 2-or 3-(N-Cyclicamino)chromone Derivatives as Monoamine Oxidase Inhibitors

Koichi Takao et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2020)

Review Chemistry, Medicinal

A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer's disease agents: A review

Shoaib Manzoor et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Medicinal

Plasma membrane redox enzymes: new therapeutic targets for neurodegenerative diseases

Dong-Hoon Hyun

ARCHIVES OF PHARMACAL RESEARCH (2019)

Article Biochemistry & Molecular Biology

Donepezil plus chromone plus melatonin hybrids as promising agents for Alzheimer's disease therapy

Irene Pachon-Angona et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)

Review Neurosciences

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

Archana Prasad et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Review Geriatrics & Gerontology

Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders

Muhammad Ayaz et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Review Clinical Neurology

Ageing as a risk factor for neurodegenerative disease

Yujun Hou et al.

NATURE REVIEWS NEUROLOGY (2019)

Article Biochemistry & Molecular Biology

In Vitro Evaluation and Docking Studies of 5-oxo-5H-furo[3,2-g]chromene-6-carbaldehyde Derivatives as Potential Anti-Alzheimer's Agents

Malose J. Mphahlele et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Synthesis and evaluation of chromone derivatives as inhibitors of monoamine oxidase

Annah N. Mpitimpiti et al.

MOLECULAR DIVERSITY (2019)

Article Chemistry, Multidisciplinary

Chromenones as Multineurotargeting Inhibitors of Human Enzymes

Carina Lemke et al.

ACS OMEGA (2019)

Article Chemistry, Medicinal

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease

Martin Estrada Valencia et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Neurosciences

Selective vulnerability in neurodegenerative diseases

Hongjun Fu et al.

NATURE NEUROSCIENCE (2018)

Review Chemistry, Medicinal

Old Drugs as New Treatments for Neurodegenerative Diseases

Fernando Duraes et al.

PHARMACEUTICALS (2018)

Review Neurosciences

Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review

Kandhasamy Sowndhararajan et al.

BRAIN SCIENCES (2018)

Article Biochemistry & Molecular Biology

Rapid synthesis of flavone-based monoamine oxidase (MAO) inhibitors targeting two active sites using click chemistry

Wei Zhen Jia et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2017)

Article Chemistry, Medicinal

Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents

Ehtesham Jameel et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Chemistry, Medicinal

Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances

Joana Reis et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Biochemistry & Molecular Biology

Capillarisin augments anti-oxidative and anti-inflammatory responses by activating Nrf2/HO-1 signaling

Jinhee Kim et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

Review Biochemistry & Molecular Biology

Coumarin: A Privileged Scaffold for the Design and Development of Antineurodegenerative Agents

Ehtesham Jameel et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2016)

Article Biochemistry & Molecular Biology

Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease

Zhimin Wang et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2016)

Article Chemistry, Medicinal

2-Azolylchromone Derivatives as Potent and Selective Inhibitors of Monoamine Oxidases A and B

Koichi Takao et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2016)

Review Chemistry, Medicinal

Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease

Mudasir Maqbool et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

Review Neurosciences

Classic and novel stem cell niches in brain homeostasis and repair

Ruihe Lin et al.

BRAIN RESEARCH (2015)

Article Biochemistry & Molecular Biology

Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

Nguyen Tuan Hiep et al.

PHYTOCHEMISTRY (2015)

Review Neurosciences

Mechanisms and Functional Significance of Stroke-Induced Neurogenesis

Quentin Marlier et al.

FRONTIERS IN NEUROSCIENCE (2015)

Review Biochemistry & Molecular Biology

Flavonoids as Therapeutic Compounds Targeting Key Proteins Involved in Alzheimer's Disease

Filipa I. Baptista et al.

ACS CHEMICAL NEUROSCIENCE (2014)

Review Chemistry, Multidisciplinary

Chromone: A Valid Scaffold in Medicinal Chemistry

Alexandra Gaspar et al.

CHEMICAL REVIEWS (2014)

Review Neurosciences

Neurogenesis in the embryonic and adult brain: same regulators, different roles

Noelia Urban et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Review Biochemistry & Molecular Biology

Protein aggregation and neurodegenerative disease

CA Ross et al.

NATURE MEDICINE (2004)