☆ 4.3 Review

Amyotrophic lateral sclerosis and delayed onset muscle soreness in light of the impaired blink and stretch reflexes - watch out for Piezo2

OPEN MEDICINE (2022)

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Article Neurosciences

Delayed Onset Muscle Soreness (DOMS): The Repeated Bout Effect and Chemotherapy-Induced Axonopathy May Help Explain the Dying-Back Mechanism in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases

Balazs Sonkodi

Summary: Delayed onset muscle soreness (DOMS) and amyotrophic lateral sclerosis (ALS) are proposed to be caused by acute compression axonopathy of sensory afferents in the muscle spindle, possibly due to genetic/environmental factors, damaging contractions, and neuroinflammatory processes. The dysfunctional microcircuits in these diseases can affect memory and learning, ultimately interfering with life-sustaining central pattern generators in ALS.

BRAIN SCIENCES (2021)

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Review Pharmacology & Pharmacy

Mechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain

Giulia Puja et al.

Summary: Persistent ocular pain caused by corneal inflammation and nerve injury leads to significant alterations along the pain axis, with changes in both primary sensory neurons in the trigeminal nerves and secondary neurons in the spinal trigeminal nucleus contributing to peripheral and central pain sensitization. Studies using animal models have provided insights into the mechanisms involved in these maladaptive changes. New techniques such as optogenetics and genetic neuronal labelling allow for investigation of identified circuits involved in nociception at the spinal and trigeminal levels. Recent advances in the discovery of molecular and cellular mechanisms contributing to pain sensitization in the trigeminal pathways are also presented.

FRONTIERS IN PHARMACOLOGY (2021)

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Editorial Material Neurosciences

Spindles are doin' it for themselves: Glutamatergic autoexcitation in muscle spindles

Guy S. Bewick et al.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

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Article Neurosciences

Vesicle-released glutamate is necessary to maintain muscle spindle afferent excitability but not dynamic sensitivity in adult mice

Kimberly Than et al.

Summary: The muscle spindle afferents are slowly adapting low threshold mechanoreceptors responsible for reporting muscle length and movement information important for motor control and proprioception. The rapidly adapting cation channel PIEZO2 is essential for muscle spindle afferent stretch sensitivity, but additional molecular elements are required for mediating the complex slowly adapting response of these afferents. Glutamate released from synaptic-like vesicles plays a crucial role in maintaining muscle spindle afferent excitability during stretch, suggesting a potential therapeutic target for normalizing their function.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

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Article Biology

Does Compression Sensory Axonopathy in the Proximal Tibia Contribute to Noncontact Anterior Cruciate Ligament Injury in a Causative Way?-A New Theory for the Injury Mechanism

Balazs Sonkodi et al.

Summary: The authors propose a new mechanism for non-contact anterior cruciate ligament injury, suggesting that it is caused by acute compression microinjury of entrapped peripheral proprioceptive sensory axons in the proximal tibia. They highlight the importance of primary damage during strenuous exercises and secondary damage during deceleration. Elevated prostaglandin E2, nitric oxide, and glutamate may play critical roles in the neuro-modulation, leading to mechano-energetic failure and inflammatory events.

LIFE-BASEL (2021)

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Article Cell Biology

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Balazs Sonkodi et al.

Summary: Post orgasmic illness syndrome is a rare condition with unknown pathomechanism and uncertain treatment, characterized by symptoms lasting 2-7 days post ejaculation. Proposed primary injury includes acute compression proprioceptive axonopathy in the muscle spindle and mitochondrial impairment. Similarities to delayed onset muscle soreness exist, but differences arise from spermidine depletion-induced physiological responses. Longitudinally, cognitive and memory consequences are noted due to learning and memory-related primary injury.

CELLS (2021)

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Article Biochemistry & Molecular Biology

Have We Looked in the Wrong Direction for More Than 100 Years? Delayed Onset Muscle Soreness Is, in Fact, Neural Microdamage Rather Than Muscle Damage

Balazs Sonkodi et al.

ANTIOXIDANTS (2020)

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Article Neurosciences

Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea

Jorge Fernandez-Trillo et al.

JOURNAL OF NEUROSCIENCE (2020)

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Article Sport Sciences

BILATERAL SENSORY DEFICITS AND WIDESPREAD HYPERALGESIA OCCUR FOLLOWING INDUCED DELAYED ONSET MUSCLE SORENESS OF THE QUADRICEPS

Carol A. Courtney et al.

INTERNATIONAL JOURNAL OF SPORTS PHYSICAL THERAPY (2020)

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Article Neurosciences

Modulation of soleus stretch reflexes during walking in people with chronic incomplete spinal cord injury

Aiko K. Thompson et al.

EXPERIMENTAL BRAIN RESEARCH (2019)

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Article Neurosciences

Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1G93A Mouse Model for ALS

Soju Seki et al.

JOURNAL OF NEUROSCIENCE (2019)

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Article Neurosciences

Circuit Dysfunction in SOD1-ALS Model First Detected in Sensory Feedback Prior to Motor Neuron Degeneration Is Alleviated by BMP Signaling

Aaron Held et al.

JOURNAL OF NEUROSCIENCE (2019)

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Review Neurosciences

Escape from homeostasis: spinal microcircuits and progression of amyotrophic lateral sclerosis

Robert M. Brownstone et al.

JOURNAL OF NEUROPHYSIOLOGY (2018)

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Article Biology

Myotubularin related protein-2 and is phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons

Pratibha Narayanan et al.

ELIFE (2018)

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Review Biochemistry & Molecular Biology

Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology

Thomas M. Suchyna

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2017)

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Review Clinical Neurology

Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis

Jik Nijssen et al.

ACTA NEUROPATHOLOGICA (2017)

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Article Neurosciences

A novel path to chronic proprioceptive disability with oxaliplatin: Distortion of sensory encoding

Jacob A. Vincent et al.

NEUROBIOLOGY OF DISEASE (2016)

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Article Rehabilitation

Delay of the Blink Reflex in Patients Receiving Platinum-Analogue Chemotherapy

Kang Young Park et al.

ANNALS OF REHABILITATION MEDICINE-ARM (2016)

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Article Neurosciences

Degeneration of proprioceptive sensory nerve endings in mice harboring amyotrophic lateral sclerosis-causing mutations

Sydney K. Vaughan et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2015)

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Article Neurosciences

Piezo2 is the principal mechanotransduction channel for proprioception

Seung-Hyun Woo et al.

NATURE NEUROSCIENCE (2015)

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Review Physiology

Piezo channels: from structure to function

Linda Volkers et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2015)

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Article Multidisciplinary Sciences

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

Sanjeev S. Ranade et al.

NATURE (2014)

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Article Ophthalmology

Wnt and Extraocular Muscle Sparing in Amyotrophic Lateral Sclerosis

Linda K. McLoon et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2014)

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Article Clinical Neurology

Blink rate in ALS

Susan Byrne et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2013)

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Article Neurosciences

Terminal arbor degeneration - a novel lesion produced by the antineoplastic agent paclitaxel

Gary J. Bennett et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2011)

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Article Neurosciences

Ankle clonus and its relationship with the medium-latency reflex response of the soleus by peroneal nerve stimulation

Hilmi Uysal et al.

JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY (2011)

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Article Neurosciences

Characterizing the Spontaneous Blink Generator: An Animal Model

Jaime Kaminer et al.

JOURNAL OF NEUROSCIENCE (2011)

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Review Clinical Neurology

Clinical diagnosis and management of amyotrophic lateral sclerosis

Orla Hardiman et al.

NATURE REVIEWS NEUROLOGY (2011)

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Article Neurosciences

Load Rather Than Length Sensitive Feedback Contributes to Soleus Muscle Activity During Human Treadmill Walking

Richard Af Klint et al.

JOURNAL OF NEUROPHYSIOLOGY (2010)

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Article Cell Biology

Wnt Signaling from Development to Disease: Insights from Model Systems

Ken M. Cadigan et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)

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Article Neurosciences

Medium-latency reflex response of soleus elicited by peroneal nerve stimulation

Hilmi Uysal et al.

EXPERIMENTAL BRAIN RESEARCH (2009)

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Article Clinical Neurology

Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?

Jeremy D. Isaacs et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2007)

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Article Neurosciences

A stretch reflex in extraocular muscles of species purportedly lacking muscle spindles

Numa Dancause et al.

EXPERIMENTAL BRAIN RESEARCH (2007)

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Article Sport Sciences

The effect of delayed-onset muscle soreness on stretch reflexes in human low back muscles

N Hjortskov et al.

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS (2005)

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Article Ophthalmology

An assessment of the pattern of spontaneous eyeblink activity under the influence of topical ocular anaesthesia

T Naase et al.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2005)

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Article Neurosciences

Autogenic modulation of mechanoreceptor excitability by glutamate release from synaptic-like vesicles: evidence from the rat muscle spindle primary sensory ending

GS Bewick et al.

JOURNAL OF PHYSIOLOGY-LONDON (2005)

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Article Clinical Neurology

Blink reflex in primary lateral sclerosis

DG Podikoglou et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2004)

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Article Ophthalmology

Stretching of the Mueller muscle results in involuntary contraction of the levator muscle

K Matsuo

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY (2002)

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Article Neurosciences

Group II muscle afferents probably contribute to the medium latency soleus stretch reflex during walking in humans

MJ Grey et al.

JOURNAL OF PHYSIOLOGY-LONDON (2001)

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Article Ophthalmology

Does extraocular muscle proprioception influence oculomotor control?

CR Weir et al.

BRITISH JOURNAL OF OPHTHALMOLOGY (2000)

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