期刊
MITOCHONDRIAL DNA PART A
卷 27, 期 6, 页码 4244-4245出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/19401736.2014.1003920
关键词
Colon cancer; D-Loop; mtDNA; SNPs
资金
- Key Basic Research Program of Hebei [14967713D]
The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in a number of cancers. We investigated the colon cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 146T/C, 195T/C, 324C/G, 16261C/T, and 16304T/C as well as the minor allele of 309C/C insert were significantly associated with an increased risk for colon cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for colon cancer risk evaluation.
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