Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response

In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated with a reduced likelihood of nodal positivity, an increased rate of pathological complete response, and improved disease-specific survival.

Automated summary

This study of 400 patients with early-onset rectal cancer found that 12.5% of patients demonstrated microsatellite instability (MSI), which was associated with reduced likelihood of nodal positivity, increased rate of pathological complete response, and improved disease-specific survival.