4.6 Review

Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate

Joanna L. Fox et al.

Summary: Regulated cell death is essential in development and cellular homeostasis. The core FADD:Caspase-8 complex and its regulatory partners, such as the cell death inhibitor c-FLIP, play a critical role in coordinating cell fate. The recruitment of c-FLIPS into this complex inhibits Caspase-8 activity by altering its structure.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

Long non-coding RNA NEAT1 regulates endothelial functions in subclinical hypothyroidism through miR-126/TRAF7 pathway

Li Wang et al.

Summary: The study found that miR-126-3p expression levels were significantly decreased in SCH, and miR-126 improved vascular function by regulating the C-FLIP pathway and endothelial apoptosis. Additionally, lncRNA NEAT1 could act as a ceRNA binding to miR-126, modulating its expression level and vascular function.

HUMAN CELL (2021)

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

Article Biochemistry & Molecular Biology

Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly

Laura K. Hillert et al.

ONCOGENE (2020)

Article Biochemistry & Molecular Biology

Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimer

Laura K. Hillert et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Biochemistry & Molecular Biology

Forefront: MiR-34a-Knockout Mice with Wild Type Hematopoietic Cells, Retain Persistent Fibrosis Following Lung Injury

Raanan Bulvik et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation

Hayley I. Muendlein et al.

SCIENCE (2020)

Review Cell Biology

Controlling Cell Death through Post-translational Modifications of DED Proteins

Kamil Seyrek et al.

TRENDS IN CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics

Jouliana Sadek et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

The pseudo-caspase FLIP(L) regulates cell fate following p53 activation

Andrea Lees et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Pharmacological targeting of c-FLIPL and Bcl-2 family members promotes apoptosis in CD95L-resistant cells

Corinna Koenig et al.

SCIENTIFIC REPORTS (2020)

Article Biotechnology & Applied Microbiology

Delineating the role of c-FLIP/NEMO interaction in the CD95 network via rational design of molecular probes

Nikita V. Ivanisenko et al.

BMC GENOMICS (2019)

Review Biochemistry & Molecular Biology

Decoding the sweet regulation of apoptosis: the role of glycosylation and galectins in apoptotic signaling pathways

Kamil Seyrek et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Biochemistry & Molecular Biology

USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability

M. Jeong et al.

ONCOGENE (2017)

Review Oncology

Necroptosis: A new way of dying?

Britt Hanson

CANCER BIOLOGY & THERAPY (2016)

Article Biochemistry & Molecular Biology

Molecular basis of death effector domain chain assembly and its role in caspase-8 activation

Nitu Singh et al.

FASEB JOURNAL (2016)

Article Oncology

FLIP: A Targetable Mediator of Resistance to Radiation in Non-Small Cell Lung Cancer

Kylie A. McLaughlin et al.

MOLECULAR CANCER THERAPEUTICS (2016)

Review Oncology

Role of miR-155 in drug resistance of breast cancer

Dan-dan Yu et al.

TUMOR BIOLOGY (2015)

Article Multidisciplinary Sciences

Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin

Gabriel Gaidos et al.

PLOS ONE (2015)

Article Oncology

Pazopanib and HDAC inhibitors interact to kill sarcoma cells

Seyedmehrad Tavallai et al.

CANCER BIOLOGY & THERAPY (2014)

Review Cell Biology

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Tom Vanden Berghe et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Editorial Material Cell Biology

Systems biology: a way to make complex problems more understandable

I. N. Lavrik et al.

CELL DEATH & DISEASE (2014)

Review Cell Biology

Systems biology of death receptor networks: live and let die

I. N. Lavrik

CELL DEATH & DISEASE (2014)

Article Multidisciplinary Sciences

Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly

J. Majkut et al.

NATURE COMMUNICATIONS (2014)

Article Hematology

Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia

Donal McLornan et al.

BRITISH JOURNAL OF HAEMATOLOGY (2013)

Review Oncology

Targeting c-FLIP in cancer

Sarah Shirley et al.

CANCER LETTERS (2013)

Review Pharmacology & Pharmacy

Targeting c-FLICE-like inhibitory protein (CFLAR) in cancer

Simone Fulda

EXPERT OPINION ON THERAPEUTIC TARGETS (2013)

Article Biochemistry & Molecular Biology

Novel Phosphorylation and Ubiquitination Sites Regulate Reactive Oxygen Species-dependent Degradation of Anti-apoptotic c-FLIP Protein

Rachel P. Wilkie-Grantham et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Cell Biology

Sorafenib and HDAC inhibitors synergize with TRAIL to kill tumor cells

Hossein A. Hamed et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells

M. Lauricella et al.

BIOCHIMIE (2012)

Review Oncology

Cellular FLICE-like inhibitory proteins (c-FLIPs): Fine-tuners of life and death decisions

Selcen Oeztuerk et al.

EXPERIMENTAL CELL RESEARCH (2012)

Article Biochemistry & Molecular Biology

Modeling Reveals That Dynamic Regulation of c-FLIP Levels Determines Cell-to-Cell Distribution of CD95-mediated Apoptosis

Hannu T. Toivonen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

Catalytic activity of the caspase-8-FLIPL complex inhibits RIPK3-dependent necrosis

Andrew Oberst et al.

NATURE (2011)

Article Cell Biology

Caspase 8 inhibits programmed necrosis by processing CYLD

Marie Anne O'Donnell et al.

NATURE CELL BIOLOGY (2011)

Article Oncology

Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells

D. Mahalingam et al.

BRITISH JOURNAL OF CANCER (2010)

Article Biochemistry & Molecular Biology

Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation

I. Verbrugge et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Biochemistry & Molecular Biology

Cellular FLICE-inhibitory protein (c-FLIP) signalling: A key regulator of receptor-mediated apoptosis in physiologic context and in cancer

Marina Bagnoli et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

Article Oncology

Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands

Tabitha E. Wood et al.

MOLECULAR CANCER THERAPEUTICS (2010)

Article Biochemistry & Molecular Biology

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

Leo Neumann et al.

MOLECULAR SYSTEMS BIOLOGY (2010)

Review Cell Biology

Molecular mechanisms of necroptosis: an ordered cellular explosion

Peter Vandenabeele et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Is TRAIL the holy grail of cancer therapy?

Thomas Newsom-Davis et al.

APOPTOSIS (2009)

Article Biochemistry & Molecular Biology

p63 regulates the caspase-8-FLIP apoptotic pathway in epidermis

S. Borrelli et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Biochemistry & Molecular Biology

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability

A. Kaunisto et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Biochemistry & Molecular Biology

IRF-5 Is a Mediator of the Death Receptor-induced Apoptotic Signaling Pathway

Guodong Hu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Oncology

Expression and biological significance of c-FLIP in human hepatocellular carcinomas

Xilin Du et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2009)

Review Biochemistry & Molecular Biology

Understanding apoptosis by systems biology approaches

Inna N. Lavrik et al.

MOLECULAR BIOSYSTEMS (2009)

Article Pharmacology & Pharmacy

Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

Teneille Walker et al.

MOLECULAR PHARMACOLOGY (2009)

Article Multidisciplinary Sciences

The Fas-FADD death domain complex structure unravels signalling by receptor clustering

Fiona L. Scott et al.

NATURE (2009)

Article Multidisciplinary Sciences

Mechanism of procaspase-8 activation by c-FLIPL

Jong W. Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signalling

Pritish S. Pawar et al.

BIOCHEMICAL JOURNAL (2008)

Article Biochemistry & Molecular Biology

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

N. Ueffing et al.

CELL DEATH AND DIFFERENTIATION (2008)

Article Multidisciplinary Sciences

Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

Ailsa J. Frew et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Immunology

Life and death in peripheral T cells

Peter H. Krammer et al.

NATURE REVIEWS IMMUNOLOGY (2007)

Article Biochemistry & Molecular Biology

Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis

J. R. Muppidi et al.

CELL DEATH AND DIFFERENTIATION (2006)

Article Immunology

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-κB activation

Alexander Golks et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

Article Biochemistry & Molecular Biology

Crystal structure of a viral FLIP - Insights into FLIP-mediated inhibition of death receptor signaling

FY Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition

JK Yang et al.

MOLECULAR CELL (2005)

Article Biochemistry & Molecular Biology

mTOR controls FLIPs translation and TRAIL sensitivity in glioblastoma multiforme cells

A Panner et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Rapid turnover of c-FLIP short is determined by its unique C-terminal tail

M Poukkula et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Oncology

Novel histone deacetylase inhibitors in the treatment of thyroid cancer

CS Mitsiades et al.

CLINICAL CANCER RESEARCH (2005)

Article Biochemistry & Molecular Biology

c-FLIPR, a new regulator of death receptor-induced apoptosis

A Golks et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Medicine, Research & Experimental

Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma

XD Zhou et al.

CLINICAL SCIENCE (2004)

Article Cell Biology

Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis

M Bentele et al.

JOURNAL OF CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity

MS Ricci et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation

YY Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Review Cell Biology

Mechanisms of caspase activation

KM Boatright et al.

CURRENT OPINION IN CELL BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis

H Higuchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

The long form of FLIP is an activator of caspase-8 at the fas death-inducing signaling complex

O Micheau et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

DW Chang et al.

EMBO JOURNAL (2002)

Article Biochemistry & Molecular Biology

Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin

EC Shin et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2002)

Review Immunology

Regulation of lymphocyte proliferation and death by flip

M Thome et al.

NATURE REVIEWS IMMUNOLOGY (2001)

Article Dermatology

Selective expression of FLIP in malignant melanocytic skin lesions

RR Bullani et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)

Article Biochemistry & Molecular Biology

NF-κB signals induce the expression of c-FLIP

O Micheau et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

NF-κB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

S Kreuz et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Multidisciplinary Sciences

Proliferation, cell cycle and apoptosis in cancer

GI Evan et al.

NATURE (2001)

Review Cell Biology

Regulation of translation initiation by FRAP/mTOR

AC Gingras et al.

GENES & DEVELOPMENT (2001)

Article Biochemistry & Molecular Biology

Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells

DJ Panka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Pharmacology & Pharmacy

Ca2+ mobilization induced by W-7 in MG63 human osteosarcoma cells

CR Jan et al.

PHARMACOLOGICAL RESEARCH (2000)