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Multicellular modules as clinical diagnostic and therapeutic targets

TRENDS IN CANCER (2022)

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Multiplexed imaging analysis of the tumor-immune microenvironment reveals predictors of outcome in triple-negative breast cancer

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Summary: The study utilizes high-dimensional tissue imaging technology to analyze the tumor-immune microenvironment in triple-negative breast cancer patients, revealing that profiling cell-to-cell interactions in the microenvironment can predict recurrence and overall survival, especially highlighting the importance of immunoregulatory proteins.

COMMUNICATIONS BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Single-cell metabolic profiling of human cytotoxic T cells

Felix J. Hartmann et al.

Summary: This antibody-based method allows profiling of metabolic protein expression and regulation in single cells using mass spectrometry while characterizing cellular phenotype. The approach was validated using mass cytometry and applied to clinical samples, revealing tissue-restricted, metabolically repressed immune cells in human colorectal carcinoma. The combination with multiplexed ion beam imaging unveiled the spatial organization of metabolic programs in human tissues.

NATURE BIOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Single-cell transcriptomic analysis of mIHC images via antigen mapping

Kiya W. Govek et al.

Summary: STvEA is a method that combines single-cell RNA sequencing data with mIHC images to achieve transcriptome-guided annotation of highly multiplexed immunohistochemistry data. This approach enables systematic annotation of nuanced cell populations, spatial patterns of transcription, and interactions between cell types, thereby increasing the level of detail in histological analyses.

SCIENCE ADVANCES (2021)

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Article Biochemical Research Methods

CODEX multiplexed tissue imaging with DNA-conjugated antibodies

Sarah Black et al.

Summary: Advances in multiplexed imaging technologies, such as CODEX, using DNA-conjugated antibodies and fluorescently labeled DNA probes, allow visualization of up to 60 markers simultaneously in tissues. This enables a deep view into single-cell spatial relationships and can drive discovery in developmental biology, disease, and therapeutic design.

NATURE PROTOCOLS (2021)

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Article Multidisciplinary Sciences

Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade

Sneha Berry et al.

Summary: A comprehensive platform for multispectral imaging and mapping of multiple parameters in tumor tissue sections was introduced, allowing high-fidelity single-cell analysis. This platform identified key features in pretreatment melanoma specimens that predicted response to anti-PD-1 therapy, and stratified long-term survival after anti-PD-1 blockade. The signature was validated in an independent cohort of melanoma patients from a different institution.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Subcellular localization of biomolecules and drug distribution by high-definition ion beam imaging

Xavier Rovira-Clave et al.

Summary: This study introduces a high-definition multiplex ion beam imaging technology that allows simultaneous visualization of multiple biomolecules and their ligands or small molecules in cells. The subcellular localization of the chemotherapy drug cisplatin was found to be related to chromatin regions, with surviving cells after multi-drug treatment showing selective exclusion of cisplatin from the nucleus, potentially modulating resistance to chemotherapy treatment.

NATURE COMMUNICATIONS (2021)

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Review Immunology

Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials

Jackson G. Egen et al.

IMMUNITY (2020)

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Review Biochemistry & Molecular Biology

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Orit Rozenblatt-Rosen et al.

CELL (2020)

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The Society for Immunotherapy of Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation

Janis M. Taube et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy

Wei Chang Colin Tan et al.

CANCER COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front

Christian M. Schurch et al.

CELL (2020)

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Engineered biomaterials for in situ tissue regeneration

Akhilesh K. Gaharwar et al.

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High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue

Yang Liu et al.

CELL (2020)

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The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

Daniela Bruni et al.

NATURE REVIEWS CANCER (2020)

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Review Oncology

Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade: A Systematic Review and Meta-analysis

Steve Lu et al.

JAMA ONCOLOGY (2019)

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Article Multidisciplinary Sciences

The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

Michael P. Snyder et al.

NATURE (2019)

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Article Biochemistry & Molecular Biology

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

Yury Goltsev et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging

Leeat Keren et al.

CELL (2018)

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Review Nanoscience & Nanotechnology

Advances in organ-on-a-chip engineering

Boyang Zhang et al.

NATURE REVIEWS MATERIALS (2018)

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Article Biology

The Human Cell Atlas

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ELIFE (2017)

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