期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 86, 期 3, 页码 397-406出版社
OXFORD UNIV PRESS
DOI: 10.1093/bbb/zbac003
关键词
Akkermansia; porcine stomach mucin; rat gastrointestinal mucin; skate-skin mucin; sulfated sugars
类别
资金
- JSPS KAKENHI [20H02929]
- Grants-in-Aid for Scientific Research [20H02929] Funding Source: KAKEN
Dietary factors can affect the abundance of Akkermansia muciniphila in the colon, with foods high in sulfated sugars and threonine promoting the proliferation of the bacteria.
Dietary factors, affect Akkermansia muciniphila (AM) abundance in the colon, have attracted attention, driven by the inverse correlation between AM abundance and metabolic disorders. We prepared skate-skin mucin (SM), porcine stomach mucin (PM), and rat gastrointestinal mucin (RM). SM contained more sulfated sugars and threonine than PM or RM. Rats were fed a control diet or diets including SM, PM, or RM (15 g/kg), or SM (12 g/kg) from 5 different threonine contents for 14 d. Cecal total bacteria and AM were less and more numerous, respectively, in SM-fed rats than the others, but SM did not affect microbial species richness. Low-threonine SM did not induce AM proliferation. The in vitro fermentation with human feces showed that the rate of AM increase was greater with SM than PM. Collectively, heavy SM sulfation facilitates a priority supply of SM-derived amino sugars and threonine that promotes AM proliferation in rats and human feces.
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