期刊
BIOCELL
卷 46, 期 6, 页码 1459-1463出版社
TECH SCIENCE PRESS
DOI: 10.32604/biocell.2022.018378
关键词
Exosomes; Mesenchymal stem cells; Regeneration
类别
资金
- National Natural Science Foundation of China [81871496, 81971757]
- Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation [ss2018003]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD III)
MSCs-derived exosomes have shown various beneficial effects in regenerative medicine and possess many excellent properties, but there are still obstacles to overcome in terms of isolation, clinical trials, and safety evaluation.
Exosomes, especially from mesenchymal stem cells, have attracted extensive attention in regeneration medicine. Mesenchymal stem cells derived exosomes (MSCs-exosomes) have shown anti-inflammatory, anti-oxidant, anti-apoptosis and tissue regeneration effects in a variety of tissue injury repair models. MSCs-exosomes hold many excellent properties such as low immunogenicity, biocompatibility, and targeting capability. With the in-depth study on the generation and function of exosomes, MSCs-exosomes are considered to be the bright stars in the field of regenerative medicine. However, there are still many obstacles to overcome in terms of exosomes isolation, clinical trials and safety evaluation. In this article, what we should focus on about MSCs-exosomes in regeneration medicine will be discussed.
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