期刊
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
卷 14, 期 2, 页码 798-818出版社
E-CENTURY PUBLISHING CORP
关键词
Hepatic malignant vascular tumors; prognostic factor; nomogram; overall survival; cancer-specific survival; SEER database
资金
- National Natural Sciences Foundation of China [81970523, 8180-0506]
- National Science and Technology Major Project of China [2018ZX10732202, 2017YFC0908104]
- Natural Sciences Foundation of Hunan province [2020JJ4877, 2020JJ5886, 2020JJ4906, 2019JJ-40496]
- Basic and Applied Basic Research Foundation of Guangdong Province [2020-A1515110491]
This study conducted the largest population-based study to describe the clinicopathologic characteristics of patients with HMVT and established and validated prognostic nomograms that accurately predicted 1-, 3-, and 5-year OS and CSS.
Objective: To characterize the clinicopathologic features and to investigate the prognostic nomograms for overall survival (OS) and cancer-specific survival (CSS) in patients with Hepatic malignant vascular tumors (HMVT). Method: Patients diagnosed with HMVT between 1973 and 2015 were screened from the Surveillance, Epidemiology, and End Results (SEER) database. The Kaplan-Meier (KM) was used for survival analysis. The univariate and multivariate Cox analyses were performed to identify independent predictors. Furthermore, the prognostic nomograms were established and evaluated. Results: A total of 510 HMVT patients were collected, and randomly divided into HMVT-training (N=308) and validation cohort (N=202) groups. The 3- and 5-year OS for overall HMVT were 21.3% and 19.8%, and the correspond ing CSS was 29.8% and 27.7% respectively. Age at diagnosis, grade, tumor size, and histological type were identified as prognostic factors for OS and CSS in patients with HMVT. However, sex was just for predicting CSS, and T stage was only an indicator of OS. These factors were further utilized to construct the nomograms for OS and CSS in the HMVT-training cohort showing credible performance with the C-index of 0.763 and 0.762, respectively. Moreover, the AUC value for 1-, 3-, 5-year OS was 0.873, 0.905 and 0.898, and the corresponding value for CSS was 0.808, 0.794 and 0.788 respectively. Additionally, the calibration curves demonstrated a favorable agreement between the predicted and actual 1-, 3- and 5-year survival rates both in the training and validated cohorts. Conclusion: This was the largest population-based study to describe the clinicopathologic characteristics in patients with HMVT. Moreover, we established and validated prognostic nomograms that indicated an accurate prediction for 1-, 3- and 5-year of OS and CSS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据