期刊
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
卷 63, 期 1, 页码 -出版社
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.63.1.20
关键词
geographic atrophy (GA); optical coherence tomography angiography (OCTA); non-exudative type 1; macular neovascularization (MNV); growth rate
资金
- Salah Foundation
- Research to Prevent Blindness, Inc. (New York, NY)
- National Eye Institute Center Core Grant [P30EY014801]
This study investigated the influence of non-exudative type 1 macular neovascularization (MNV) on the growth of geographic atrophy (GA). The results showed a weak positive correlation between the distance to MNV and local GA growth rates, indicating that MNV may have a limited effect on GA growth.
PURPOSE. The local growth rates of geographic atrophy (GA) adjacent to non-exudative type 1 macular neovascularization (MNV) were investigated to determine if MNV influ-enced GA growth. METHODS. Eyes with GA and non-exudative type 1 MNV were followed for at least 1 year. Both GA and the MNV were imaged and measured using swept-source optical coher-ence tomography angiography (SS-OCTA) scans. Pearson correlations were computed between local growth rates of GA, which were estimated using a biophysical GA growth model, and local distances-to-MNV. Corresponding P values for the null hypothesis of no Pearson correlation were computed using a Monte Carlo approach that adjusts for spatial autocorrelations. RESULTS. Nine eyes were included in this study. There were positive correlations (Pearson's r > 0) between distance-to-MNV and local GA growth in eight (89%) of the eyes; however, in all but one eye (11%), correlations were relatively weak and statistically nonsignificant after Bonferroni correction (corrected P > 0.05). CONCLUSIONS. SS-OCTA imaging combined with GA growth modeling and spatial statistical analysis enabled quantitative assessment of correlations between local GA growth rates and local distances-to-MNV. Our results are not consistent with non-exudative type 1 MNV having a strong inhibitory effect on local GA growth rates.
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