期刊
BRAIN
卷 145, 期 1, 页码 17-26出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/awab366
关键词
astrocytes; prion-like; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis
资金
- Francis Crick Institute - Cancer Research UK [65 (FC010110)]
- UK Medical Research Council [FC010110]
- Wellcome Trust [FC010110]
- MRC Senior Clinical Fellowship [MR/S006591/1]
- Lister Research Prize Fellowship
Accumulating evidence suggests that astrocytes play a key role in neurodegenerative diseases by dealing with pathological protein aggregates and their prion-like behavior. However, their specific functions and their interactions with the disease process are still unclear.
Accumulating evidence suggests that neurodegenerative diseases are not merely neuronal in nature but comprise multicellular involvement, with astrocytes emerging as key players. The pathomechanisms of several neurodegenerative diseases involve the deposition of misfolded protein aggregates in neurons that have characteristic prion-like behaviours such as template-directed seeding, intercellular propagation, distinct conformational strains and protein-mediated toxicity. The role of astrocytes in dealing with these pathological prion-like protein aggregates and whether their responses either protect from or conspire with the disease process is currently unclear. Here we review the existing literature implicating astrocytes in multiple neurodegenerative proteinopathies with a focus on prion-like behaviour in this context.
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