期刊
CHEMISTRYSELECT
卷 1, 期 18, 页码 5784-5788出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201601221
关键词
N-heterocycles; Reductive cyclization; Domino reaction; Mo(VI)-catalysis; Nitroaromatics
资金
- Department of Science and Technology (DST), Science and Engineering Research Board (SERB), New Delhi [ECR/2016/000337]
- Ministry of Human Resource and Development (MHRD), New Delhi
An efficient and operational simple synthetic method has been developed towards the preparation of important biologically active N-heterocyclic scaffolds. The present method associated with the use of inexpensive and easy to prepare nitroaromatics as substrates. The key step of the developed protocol rely on the reductive cyclization of nitro-compounds in presence of Mo (VI) as catalyst and phosphine as deoxygenative agent. It has been shown that depending on the nature of substrates two distinct heterocyclic scaffolds such as 1-hydroxyphenazines and quinoxalines can be synthesized in high yields. It is envisaged that both 1-hydroxyphenazines and quinoxalines exhibits potential pharmacological profiles and offers novel landscapes in medicinal chemistry, and drug discovery research. Considering the limited number of methods available in literature for the preparation of 1-hydroxyphenazines, the present method serves an efficient and economical alternative towards this scaffold.
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