期刊
NATURAL PRODUCT REPORTS
卷 39, 期 5, 页码 1015-1044出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1np00060h
关键词
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资金
- National Natural Science Foundation of China [21871228]
- Natural Science Foundation of Yunnan Province [2018FY001015]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_17R94]
This review summarizes the structural diversity and chemical synthesis of complex cyclotryptamine alkaloids with a bispyrrolidino[2,3-b]indoline (BPI) skeleton. These compounds exhibit wide systematic occurrences, large structural diversity, and multiple biological activities. Despite their structural complexity, remarkable progress has been made in the last six decades, and several successful methods have been established for their construction.
Covering up to 2021 Complex cyclotryptamine alkaloids with a bispyrrolidino[2,3-b]indoline (BPI) skeleton are an intriguing family of natural products, exhibiting wide systematic occurrences, large structural diversity, and multiple biological activities. Based on their structural characteristics, BPI alkaloids can be classified into chimonanthine-type BPI alkaloids, BPI diketopiperazines, and BPI epipolythiodiketopiperazines. These intricate molecules have captivated great attention soon after their isolation and identification in the 1960s. Due to the structural complexity, the total synthesis of these cyclotryptamine alkaloids is challenging. Nevertheless, remarkable progress has been achieved in the last six decades; in particular, several methods have been successfully established for the construction of vicinal all-carbon quaternary stereocenters. In this review, the structural diversity and chemical synthesis of these BPI alkaloids were summarized. BPI alkaloids are mainly synthesized by the methods of oxidative dimerization, reductive dimerization, and alkylation of bisoxindole. The purpose of this review is to present overall strategies for assembling the BPI skeleton and efforts towards controlling the stereocenters.
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