4.0 Review

A local QSAR model based on the stability of nitrenium ions to support the ICH M7 expert review on the mutagenicity of primary aromatic amines

期刊

GENES AND ENVIRONMENT
卷 44, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s41021-022-00238-1

关键词

Primary aromatic amine; Quantitative structure-activity relationship (QSAR); In silico; Nitrenium ion; ICH M7; Expert review

向作者/读者索取更多资源

This study developed a shareable QSAR tool based on nitrenium ion stability and evaluated its prediction accuracy using in-house aromatic amine intermediates. The results showed that the tool has comparable performance to commercial QSAR tools and can provide quantitative indicators to support expert review. This local QSAR tool is useful for explaining the substituent effects on the mutagenicity of primary aromatic amines.
Background: Aromatic amines, often used as intermediates for pharmaceutical synthesis, may be mutagenic and therefore pose a challenge as metabolites or impurities in drug development. However, predicting the mutagenicity of aromatic amines using commercially available, quantitative structure-activity relationship (QSAR) tools is difficult and often requires expert review. In this study, we developed a shareable QSAR tool based on nitrenium ion stability. Results: The evaluation using in-house aromatic amine intermediates revealed that our model has prediction accuracy of aromatic amine mutagenicity comparable to that of commercial QSAR tools. The effect of changing the number and position of substituents on the mutagenicity of aromatic amines was successfully explained by the change in the nitrenium ion stability. Furthermore, case studies showed that our QSAR tool can support the expert review with quantitative indicators. Conclusions: This local QSAR tool will be useful as a quantitative support tool to explain the substituent effects on the mutagenicity of primary aromatic amines. By further refinement through method sharing and standardization, our tool can support the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 expert review with quantitative indicators.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.0
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据