The Role of Selenium in Pathologies: An Updated Review

Article Nutrition & Dietetics

The effects of selenium administration on carotid intima-media thickness and metabolic status in diabetic hemodialysis patients: A randomized, double-blind, placebo-controlled trial

Marzieh Salimian et al.

Summary: This study demonstrates the beneficial effects of selenium supplementation on insulin metabolism, cholesterol levels, and inflammation markers in diabetic hemodialysis patients.

CLINICAL NUTRITION ESPEN (2022)

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Review Food Science & Technology

Nutritional status and follicular-derived thyroid cancer: An update

Luigi Barrea et al.

Summary: The incidence of thyroid cancer is increasing globally, and factors such as iodine intake, dietary habits, and obesity are closely related to the risk of developing thyroid cancer. Low iodine intake may increase the risk of thyroid cancer, while obesity is associated with more aggressive behavior of thyroid cancer.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2021)

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Article Neurosciences

Selenium level does not differ in blood but increased in cerebrospinal fluid in Parkinson's disease: a meta-analysis

Yu-Jing Zhang et al.

Summary: Selenium levels are associated with the risk of Parkinson's disease, with significantly higher cerebrospinal fluid selenium levels found in PD patients compared to controls. The findings can contribute to a better understanding of the association between selenium and PD.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2021)

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Article Biochemistry & Molecular Biology

Interplay Between Oxidative Stress, Cyclooxygenases, and Prostanoids in Cardiovascular Diseases

Sha Zhao et al.

Summary: This review discusses the important role and interactions between oxidative stress, COXs, and prostanoids in cardiovascular diseases, highlighting recent advances in drug research and future directions for further studies.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Article Biochemistry & Molecular Biology

Selenium Restores Synaptic Deficits by Modulating NMDA Receptors and Selenoprotein K in an Alzheimer's Disease Model

Zhong-Hao Zhang et al.

Summary: The study shows that the Se compound Se-Met can restore synaptic deficits in 3 x Tg-AD mice by modulating calcium influx mediated by synaptic and extrasynaptic NMDARs, indicating a potential functional interaction between SELENOK and NMDARs.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Article Biochemistry & Molecular Biology

Prenatal Maternal Low Selenium, High Thyrotropin, and Low Birth Weights

Xiangrong Guo et al.

Summary: The study revealed a non-linear association between maternal selenium status and TSH levels, suggesting that low selenium status during pregnancy may be associated with low thyroid function and low birth weight.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Preventive and Therapeutic Strategies in Alzheimer's Disease: Focus on Oxidative Stress, Redox Metals, and Ferroptosis

German Plascencia-Villa et al.

Summary: There is currently no effective treatment for neurodegenerative diseases like Alzheimer's disease, with clinical trials focusing on amyloid treatments facing challenges and setbacks. Research is now shifting towards alternative areas such as ApoE, oxidative stress, and neuroinflammation as potential new avenues for therapeutic development.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Review Endocrinology & Metabolism

Selenium: A Trace Element for a Healthy Skeleton - A Narrative Review

Fabio Vescini et al.

Summary: Inadequate serum selenium levels can delay growth and physiological changes in bone metabolism. Reduced selenium concentrations are associated with increased bone turnover and reduced bone mineral density. Selenium-proteins play a key role in protecting bone cells from oxidative stress and maintaining bone health.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2021)

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Article Biochemistry & Molecular Biology

Zinc and Selenium in Inflammatory Bowel Disease: Trace Elements with Key Roles?

Mostafa Vaghari-Tabari et al.

Summary: Inflammatory bowel disease is a chronic inflammatory condition with phases of recurrence and remission, potentially caused by an inappropriate immune response to intestinal flora bacteria. Oxidative stress and free radicals play a role in its pathogenesis, and antioxidants as well as trace elements like zinc and selenium are suggested for therapeutic approaches.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Article Integrative & Complementary Medicine

The effect of selenium and vitamin E supplementation on anti-Mullerian hormone and antral follicle count in infertile women with occult premature ovarian insufficiency: A randomized controlled clinical trial

Farhadi Dizaji Safiyeh et al.

Summary: Supplementation with selenium and vitamin E can increase levels of AMH, AFC, and MOV in women with occult premature ovarian insufficiency, without any side effects.

COMPLEMENTARY THERAPIES IN MEDICINE (2021)

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Article Nutrition & Dietetics

Sex-dependent association between selenium status and cognitive performance in older adults

Barbara R. Cardoso et al.

Summary: This study reveals sex differences in the association between selenium status and cognitive performance in older adults, with a positive association observed in males but not in females.

EUROPEAN JOURNAL OF NUTRITION (2021)

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Article Pharmacology & Pharmacy

Effect of chitosan oligosaccharide-conjugated selenium on improving immune function and blocking gastric cancer growth

Zhiwen Jiang et al.

Summary: Selenium and selenium-oligosaccharides have potential as chemopreventive agents against cancer, but there is a need for artificial synthesis due to insufficient natural production. Chitosan, a widely used biomaterial, is water insoluble at neutral pH, highlighting the importance of researching chitosan oligosaccharides for their water solubility.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker

Raban Arved Heller et al.

Summary: The study found that zinc deficiency is common among COVID-19 patients and has predictive value for survival. Additionally, selenium deficiency is also prevalent in patients, and a combined deficit of zinc and selenium is associated with survival rates.

REDOX BIOLOGY (2021)

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Review Chemistry, Applied

Synthesis and Applications of Organic Selenols

Damiano Tanini et al.

Summary: The synthesis and study of organoselenium compounds have received extensive attention, with selenium-containing organic molecules being widely used in organic synthesis, materials science, and medicinal chemistry. Selenols are a versatile class of molecules that easily undergo various transformations and play important roles in chemical sciences.

ADVANCED SYNTHESIS & CATALYSIS (2021)

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Article Biochemistry & Molecular Biology

Precision Redox: The Key for Antioxidant Pharmacology

Jiao Meng et al.

Summary: The redox balance of cells is crucial for providing a stable environment for biological macromolecules, and its imbalance is closely related to disease development. Precision redox strategies, emphasizing differences in redox status and proposing the 5R principle, are key for successful antioxidant pharmacology. The precise application of antioxidants is crucial for general health and should consider individual variations.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Article Biochemistry & Molecular Biology

Oxidative Stress in Oocytes and Embryo Development: Implications for In Vitro Systems

Jing Lin et al.

Summary: This study highlights the significance of considering the dynamic balance and roles of reactive oxygen species (ROS) in in vitro culture of human oocytes and embryos. An imbalance between pro-oxidants and antioxidants may explain the high failure rate of assisted reproduction, emphasizing the importance of further research to establish an optimal redox state in in vitro culture systems.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Article Biochemistry & Molecular Biology

Relationship Between Selenium in Human Tissues and Breast Cancer: a Meta-analysis Based on Case-Control Studies

Xiaopan Zhu et al.

Summary: The study found a negative correlation between selenium levels in human tissues and the risk of breast cancer, which may help deepen the understanding of the effects of selenium on human health.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Article Obstetrics & Gynecology

Effects of selenium supplementation on pregnancy outcomes and disease progression in HIV-infected pregnant women in Lagos: A randomized controlled trial

Kehinde S. Okunade et al.

Summary: Selenium supplementation has positive effects on pregnancy outcomes among HIV-infected women, reducing the risk of preterm delivery.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2021)

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Article Cell Biology

Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium

Matshediso Zachariah et al.

Summary: Selenium is an essential trace element for human health, but a balanced intake is crucial for maximizing its health benefits. High selenium intake above physiological levels may increase diabetes risk and result in endothelial dysfunction. Selenium induces cancer cell apoptosis via endoplasmic reticulum stress, but its role in endothelial dysfunction remains unknown.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Chemistry, Medicinal

Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action

Damiano Tanini et al.

Summary: The new organochalcogenides with sulfonamide moiety act as potent inhibitors of CA isoforms, particularly hCA II and VII, showing potent neuropathic pain attenuating effects. They also enhance the anticancer drugs' capability in counteracting breast cancer MCF7 cell viability. The simultaneous anti-neuropathic pain and antiproliferative effects of the new chalcogenide-based CA inhibitors represent an innovative approach for managing side effects associated with clinically platinum drugs as antitumor agents.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Nutrition & Dietetics

Dietary Habits, Selenium, Copper, Zinc and Total Antioxidant Status in Serum in Relation to Cognitive Functions of Patients with Alzheimer's Disease

Katarzyna Socha et al.

Summary: The study examined selenium, copper, zinc, and total antioxidant status (TAS) in the serum of patients with Alzheimer's disease (AD) compared to healthy individuals. Lower concentrations of selenium, zinc, and TAS, as well as a higher copper:zinc ratio, were observed in the serum of AD patients. Dietary habits were found to have a significant impact on the concentrations of these parameters in the serum of individuals with AD.

NUTRIENTS (2021)

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Review Nutrition & Dietetics

Dietary Factors Modulating Colorectal Carcinogenesis

Filippo Vernia et al.

Summary: Colorectal cancer is influenced by a combination of genetic and environmental factors, with diet and lifestyle modifications playing a significant role in reducing the risk and preventing tumors. The Western diet high in fat, red meat, and processed meat is associated with an increased risk of colorectal cancer, while a high intake of dietary fiber can partially counteract these negative effects.

NUTRIENTS (2021)

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Article Chemistry, Multidisciplinary

Proton Transfer and SN2 Reactions as Steps of Fast Selenol and Thiol Oxidation in Proteins: A Model Molecular Study Based on GPx

Marco Dalla Tiezza et al.

Summary: The study demonstrates that enzymatic environment significantly reduces the energy barrier for peroxide reduction, and the energetics is more favorable in the GPx active site. Additionally, the role of selenium in the peroxide reduction process is highlighted, showcasing its advantages in acidic and nucleophilic properties.

CHEMPLUSCHEM (2021)

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Article Biochemistry & Molecular Biology

Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy

M. S. Petronek et al.

Summary: The metabolic differences between cancer cells and normal cells present an opportunity to develop new therapeutic approaches, and the pro-oxidant and antioxidant properties of melatonin, vitamin E, selenium, and vitamin C can be effectively utilized to improve cancer patient outcomes.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Synthesis of functionalised organochalcogenides and in vitro evaluation of their antioxidant activity

Antonella Capperucci et al.

Summary: The study found that some tellurium and selenium compounds exhibited low cytotoxicity on normal human dermal fibroblasts, with some even proving to be non-toxic and having no impact on cell viability. Additionally, the selected organotellurium compounds showed significant antioxidant potential, particularly under conditions of exogenously induced oxidative stress. Additionally, the replacement of selenium with tellurium in active tellurides resulted in a significant increase in peroxidase activity.

BIOORGANIC CHEMISTRY (2021)

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Review Food Science & Technology

Glutathione peroxidase-1 and neuromodulation: Novel potentials of an old enzyme

Garima Sharma et al.

Summary: Glutathione peroxidase (GPx) acts in coordination with other signaling molecules to exert its antioxidant role and may serve as a neuro-modulator in certain neuropsychiatric conditions. This review aims to highlight the mechanistic scenarios mediated by the GPx/GPx-1 gene in impacting neurodegenerative and neuropsychiatric disorders, providing new insights for therapeutic interventions.

FOOD AND CHEMICAL TOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

Arsenic and selenium measurements in nail and hair show important relationships to Alzheimer's disease in the elderly

Emel Koseoglu et al.

Summary: The levels of arsenic and selenium in hair and nail samples of Alzheimer's Disease patients were significantly higher than those in healthy subjects, with a positive correlation between the two elements. It is suggested that the levels of arsenic and selenium may increase due to shared metabolic or genetic factors, potentially impacting the regulation of selenium pools in the disease. Further studies are needed for verification and more detailed evaluations, including genetic analyses and examination of different chemical forms of these elements.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Selenium Biofortification: Roles, Mechanisms, Responses and Prospects

Akbar Hossain et al.

Summary: Selenium is a crucial trace element for many living organisms, playing vital roles in immune, reproductive, thyroid, brain functions, and enzyme activity. Increasing plant uptake of selenium is a potential pathway to overcome human deficiencies, with selenium biofortification already established as a pioneering approach. Molecular breeding, genetic engineering, and novel agronomic management approaches are essential for successful selenium biofortification.

MOLECULES (2021)

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Article Cardiac & Cardiovascular Systems

Dietary selenium intake and risk of hospitalization for type 2 diabetes in the Moli-sani study cohort

Marco Vinceti et al.

Summary: High dietary selenium intake was associated with an increased risk of hospitalization for type 2 diabetes, particularly in men. Risk was 64% higher in the fourth quartile compared to the first quartile. This suggests that selenium intake may have an impact on the risk of developing type 2 diabetes.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

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Review Neurosciences

Roles of Selenoproteins in Brain Function and the Potential Mechanism of Selenium in Alzheimer's Disease

Zhong-Hao Zhang et al.

Summary: Selenium and its compounds show potential in preventing and treating Alzheimer's disease, mainly through selenoproteins that play crucial roles in brain function. Analysis of 25 selenoproteins in the brain revealed certain selenoproteins highly expressed in AD-related brain regions, suggesting their involvement in AD pathology. The review discusses the functions of these selenoproteins in AD, indicating new research directions for understanding the mechanism of Selenium in Alzheimer's disease.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Biochemistry & Molecular Biology

Selenium-Binding Protein 1 (SELENBP1) Supports Hydrogen Sulfide Biosynthesis and Adipogenesis

Elisa B. Randi et al.

Summary: The study found that SELENBP1 plays a crucial role in adipocyte differentiation in vitro. Silencing SELENBP1 led to decreased H2S levels, suppressed expression of the three classical H2S-producing enzymes, and significantly inhibited adipocyte differentiation.

ANTIOXIDANTS (2021)

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Review Toxicology

Toxicology and pharmacology of synthetic organoselenium compounds: an update

Cristina W. Nogueira et al.

Summary: Organoselenium compounds have complex pharmacological properties, showing strong anti-inflammatory and antioxidant activities, though the understanding of their specific molecular targets is still unclear.

ARCHIVES OF TOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

The Pharmacology and Therapeutic Utility of Sodium Hydroselenide

Kavitej Samra et al.

Summary: Metabolically active gasotransmitters like nitric oxide, carbon monoxide, and hydrogen sulfide are important signalling molecules with therapeutic potential in oxidative pathologies. Sodium hydroselenide (NaHSe), a simple selenide salt, has shown significant metabolic activity by inhibiting cytochrome C oxidase and impacting selenoprotein expression. The oxidation status of selenium plays a crucial role in protein expression and the use of NaHSe as a potential therapeutic agent warrants further research and clinical implications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Ophthalmology

Oral selenium improved the disease activity in patients with mild Graves' orbitopathy

M. Almanza-Monterrubio et al.

Summary: This study is the first to demonstrate in a Mexican population that oral selenium can reduce disease progression and clinical activity in patients with mild GO. Statistically significant differences were found in the selenium group, while no changes were observed in the placebo group. No adverse events were reported.

JOURNAL FRANCAIS D OPHTALMOLOGIE (2021)

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Article Nutrition & Dietetics

Dietary Supplementation with Selenium and Coenzyme Q10 Prevents Increase in Plasma D-Dimer While Lowering Cardiovascular Mortality in an Elderly Swedish Population

Urban Alehagen et al.

Summary: Supplementation with selenium and coenzyme Q(10) can reduce D-dimer levels and the risk of cardiovascular mortality. The study results demonstrate that supplementation can prevent an increase in D-dimer, lower cardiovascular mortality, and reveal important associations between inflammation, endothelial function, and cardiovascular risk.

NUTRIENTS (2021)

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Review Nutrition & Dietetics

Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity

Dominika Radomska et al.

Summary: This review discusses the importance of selenium in human diet, its biological activity through selenoproteins, and its impact on thyroid hormones and other functions. Additionally, it explores the influence of selenium on COVID-19 and cancer risk.

NUTRIENTS (2021)

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Review Pharmacology & Pharmacy

Chemopreventive and Anticancer Property of Selenoproteins in Obese Breast Cancer

Supriya Bevinakoppamath et al.

Summary: Obesity is a significant risk factor for various cancers, including breast cancer, due to the increased levels of inflammatory cytokines driving pro-proliferative pathways. The association of obesity with breast cancer is mainly attributed to elevated estrogen levels and oxidative stress caused by chronic low-grade inflammation.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Endocrinology & Metabolism

The Involvement of Selenium in Type 2 Diabetes Development Related to Obesity and Low Grade Inflammation

Rossukon Wongdokmai et al.

Summary: The study found significant associations between serum selenium and high-sensitivity C-reactive protein concentrations with fasting blood glucose, glycated hemoglobin, and prevalence of prediabetes or diabetes. Low and high serum selenium concentrations, as well as increasing levels of hs-CRP, were linked with an increased risk of prediabetes or diabetes.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2021)

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Review Health Care Sciences & Services

The correlation between selenium levels and autoimmune thyroid disease: a systematic review and meta-analysis

Ying Zuo et al.

Summary: Selenium supplementation was effective in treating patients with autoimmune thyroid disease, significantly reducing FT3, FT4, and TPOAb levels. There were no significant differences in TSH and TGAb levels between the experimental group and the control group.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Nutrition & Dietetics

Association of Selenium Intake and Development of Depression in Brazilian Farmers

Tatiana Lourenconi Ferreira de Almeida et al.

Summary: This study found that high selenium intake is associated with a lower prevalence of depressive symptoms among farmers, even after adjusting for other factors. The research also discovered associations between depression and factors such as gender, marital status, and socioeconomic status among farmers.

FRONTIERS IN NUTRITION (2021)

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Article Chemistry, Applied

Click Reaction of Selenols with Isocyanates: Rapid Access to Selenocarbamates as Peroxide-Switchable Reservoir of Thiol-peroxidase-Like Catalysts

Antonella Capperucci et al.

Summary: Selenols react with isocyanates to generate selenocarbamates in good yield under mild conditions, showing high selectivity over competing nucleophilic additions. The selenocarbamates exhibited thiol-peroxidase-like properties, enabling the reduction of hydrogen peroxide at the expense of thiols.

ADVANCED SYNTHESIS & CATALYSIS (2021)

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Article Chemistry, Applied

Effect of boiling and frying on the selenium content, speciation, and in vitro bioaccessibility of selenium-biofortified potato (Solanum tuberosum L.)

Zhou Dong et al.

Summary: This study found that boiling is a more suitable method for cooking selenium-enriched potatoes, as it can maintain more selenium content and enhance the bioaccessibility of selenium.

FOOD CHEMISTRY (2021)

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Article Environmental Sciences

Comparison of nanoparticle-selenium, selenium-enriched yeast and sodium selenite on the alleviation of cadmium-induced inflammation via NF-kB/IκB pathway in heart

Jing Ge et al.

Summary: This study aimed to compare the superior antagonistic effects of Nano-Se, SeY, and SSe on Cd-induced inflammation response through the NF-kB/I kappa B pathway in the heart. Results demonstrated that Nano-Se was more effective in reversing Cd-induced histopathological changes and iNOS activities, reducing Cd accumulation, and antagonizing Cd-triggered inflammation response in chicken hearts compared to SeY and SSe. Se applications, especially Nano-Se, can be most efficiently used for relieving cardiotoxicity induced by Cd exposure.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Review Nutrition & Dietetics

Food Sources of Selenium and Its Relationship with Chronic Diseases

Wenli Hu et al.

Summary: Selenium is an essential micronutrient for mammals, with deficiency posing a serious threat to health. Biofortification strategies have been developed to combat selenium deficiency. While selenium supplementation is beneficial for preventing and treating chronic diseases, the effects may vary depending on individual baseline selenium status.

NUTRIENTS (2021)

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Article Endocrinology & Metabolism

Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study

Huan Hu et al.

Summary: There was a significant, non-linear, negative association between plasma selenium and first stroke in males, but not in females. Males with higher selenium levels had lower risks of first total stroke and first ischemic stroke, especially when combined with higher vitamin E levels. No significant association was observed between plasma selenium and first hemorrhagic stroke risk in either males or females.

BIOLOGY OF SEX DIFFERENCES (2021)

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Review Neurosciences

Therapeutic Potential of Selenium in Glioblastoma

Eduard Yakubov et al.

Summary: Little progress has been made in the long-term management of malignant brain tumors, especially in the case of glioblastoma. Selenium may have positive effects in glioblastoma treatment, offering promising chances to overcome the current limitations in surgical treatment and radiochemotherapy outcomes.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Medicine, General & Internal

Effects of Selenium Supplementation on Sperm Parameters and DNA-Fragmentation Rate in Patients with Chronic Autoimmune Thyroiditis

Rossella Cannarella et al.

Summary: The study evaluated the effects of oral Se supplementation on conventional sperm parameters and DNA fragmentation in patients with AT of reproductive age with normal thyroid function. Results showed that after Se supplementation, patients had improved sperm parameters and reduced DNA fragmentation, suggesting that Se supplementation may be a potential therapeutic option for male infertility. Further studies are needed to confirm these findings and clarify the potential thyroid hormone dependency.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Plant Sciences

Joint Biofortification of Plants with Selenium and Iodine: New Field of Discoveries

Nadezhda Golubkina et al.

Summary: This study discusses the outcome of joint plant Se-I biofortification, as well as factors affecting Se and I accumulation in plants. Special attention is paid to unsolved issues in this field.

PLANTS-BASEL (2021)

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Article Medicine, Research & Experimental

Effect of selenium-enriched yeast supplementation on serum thyroid-stimulating hormone and anti-thyroid peroxidase antibody levels in subclinical hypothyroidism: Randomized controlled trial

Leila Mahmoudi et al.

Summary: The study found that selenium supplementation did not have a significant effect on thyroid hormone and anti-thyroid peroxidase antibody levels in patients with subclinical hypothyroidism. Further research with larger sample sizes and different selenium doses is needed to obtain more precise results.

ADVANCED BIOMEDICAL RESEARCH (2021)

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Article Immunology

Supranutritional selenium suppresses ROS-induced generation of RANKL-expressing osteoclastogenic CD4+ T cells and ameliorates rheumatoid arthritis

Jiahuan Qin et al.

Summary: This study indicates that in an area with supranutritional selenium intake, RA patients had lower serum selenium levels, while patients with higher selenium levels showed milder disease and lower inflammatory markers. Mouse model studies demonstrated that selenium supplementation delayed disease onset and reduced joint pathology.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

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Review Oncology

Therapeutic Potential of Selenium and Selenium Compounds in Cervical Cancer

Ewa Jablonska et al.

Summary: Cervical cancer is strongly associated with HPV infection, but its development also depends on individual genetic background, environmental factors, and diet. Selenium, an essential trace element with antiviral and antitumor properties, has not been as extensively studied in cervical cancer as in other cancers.

CANCER CONTROL (2021)

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Review Nutrition & Dietetics

A Mechanistic Link Between Selenium and Coronavirus Disease 2019 (COVID-19)

Saroj Khatiwada et al.

Summary: COVID-19 is a rapidly emerging disease caused by SARS-CoV-2 and has affected millions of people worldwide. Selenium plays a key role in strengthening immunity, reducing oxidative stress, preventing viral infections and supporting critical illness. Selenium supplementation may act as supportive therapy in reducing the risk and severity of COVID-19.

CURRENT NUTRITION REPORTS (2021)

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Article Cardiac & Cardiovascular Systems

Trace elements in patients with aortic valve sclerosis

Hataw Al-Taesh et al.

Summary: This study investigated the relationship between trace element levels and aortic valve sclerosis (AVSc), aiming to explore the potential clinical significance of serum zinc, selenium, copper, and iron concentrations as biomarkers for AVSc. The results showed that AVSc patients had significantly lower serum zinc levels compared to healthy subjects, while there were no significant differences in serum iron, selenium, and copper levels. AVSc patients also exhibited a higher prevalence of obesity, hypertension, and diabetes.

THERAPEUTIC ADVANCES IN CARDIOVASCULAR DISEASE (2021)

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Review Endocrinology & Metabolism

Selenium in colorectal and differentiated thyroid cancer

Anna P. Kipp

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (2020)

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Review Endocrinology & Metabolism

Selenoprotein P and its potential role in Alzheimer's disease

Nikolay Solovyev

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (2020)

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Article Biochemistry & Molecular Biology

Selenium speciation analysis in the cerebrospinal fluid of patients with Parkinson's disease

Fabian Maass et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2020)

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Review Public, Environmental & Occupational Health

Selenium and Other Trace Elements in the Etiology of Parkinson's Disease: A Systematic Review and Meta-Analysis of Case-Control Studies

Giorgia Adani et al.

NEUROEPIDEMIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Selenium Deficiency Induces Inflammation via the iNOS/NF-κB Pathway in the Brain of Pigs

Yilei Zhang et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2020)

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Review Oncology

Selenium and thyroid cancer: a systematic review

Monica de Oliveira Maia et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2020)

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Review Nutrition & Dietetics

Trace elements in schizophrenia: a systematic review and meta-analysis of 39 studies (N=5151 participants)

Amene Saghazadeh et al.

NUTRITION REVIEWS (2020)

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Article Biochemistry & Molecular Biology

Regulatory Phenomena in the Glutathione Peroxidase Superfamily

Regina Brigelius-Flohe et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Review Biochemistry & Molecular Biology

Antioxidant Enzymes and Male Fertility: Lessons from Knockout Models

Eleonora Scarlata et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Review Food Science & Technology

Does dietary intake of selenium protect against cancer? A systematic review and meta-analysis of population-based prospective studies

Angelica Kuria et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

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Article Cardiac & Cardiovascular Systems

Selenium and outcome in heart failure

Nils Bomer et al.

EUROPEAN JOURNAL OF HEART FAILURE (2020)

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Article Chemistry, Medicinal

Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors

Damiano Tanini et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Obstetrics & Gynecology

The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial

Anne Z. Steiner et al.

FERTILITY AND STERILITY (2020)

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Article Biochemistry & Molecular Biology

Evaluation of Thio- and Seleno-Acetamides Bearing Benzenesulfonamide as Inhibitor of Carbonic Anhydrases from Different Pathogenic Bacteria

Andrea Angeli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Comparison of three oral selenium compounds in cancer patients: Evaluation of differential pharmacodynamic effects in normal and malignant cells

Stephen O. Evans et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2020)

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Review Endocrinology & Metabolism

Selenium in thyroid disorders - essential knowledge for clinicians

Kristian Hillert Winther et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

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Article Medicine, General & Internal

Gender difference in the association of serum selenium with all-cause and cardiovascular mortality

Jie Li et al.

POSTGRADUATE MEDICINE (2020)

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Article Multidisciplinary Sciences

Control of protein function through oxidation and reduction of persulfidated states

E. Doka et al.

SCIENCE ADVANCES (2020)

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Article Nutrition & Dietetics

Selenium Supplementation and Prostate Health in a New Zealand Cohort

Nishi Karunasinghe et al.

NUTRIENTS (2020)

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Review Biochemistry & Molecular Biology

Selenium Anticancer Properties and Impact on Cellular Redox Status

Lolita Kursvietiene et al.

ANTIOXIDANTS (2020)

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Article Biochemical Research Methods

Ability of selenium species to inhibit metal-induced Aβ aggregation involved in the development of Alzheimer's disease

David Vicente-Zurdo et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Endogenous and Exogenous Antioxidants As a Tool to Ameliorate Male Infertility Induced by Reactive Oxygen Species

Tania R. Dias et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Article Biotechnology & Applied Microbiology

The Correlation between Dietary Selenium Intake and Type 2 Diabetes: A Cross-Sectional Population-Based Study on North Chinese Adults

Sultan Mehmood Siddiqi et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Clinical Advances in Sex- and Gender-Informed Medicine to Improve the Health of All A Review

Deborah Bartz et al.

JAMA INTERNAL MEDICINE (2020)

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Current Knowledge on Selenium Biofortification to Improve the Nutraceutical Profile of Food: A Comprehensive Review

Roberto D'Amato et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Review Cell Biology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Helmut Sies et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Selenoprotein T: An Essential Oxidoreductase Serving as a Guardian of Endoplasmic Reticulum Homeostasis

Hugo Pothion et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Review Biochemistry & Molecular Biology

Dietary Antioxidants and Parkinson's Disease

Han-A Park et al.

ANTIOXIDANTS (2020)

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Article Endocrinology & Metabolism

Selenium-binding protein 1 alters energy metabolism in prostate cancer cells

Mostafa Elhodaky et al.

PROSTATE (2020)

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Article Reproductive Biology

Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data

Izhar Hyder Qazi et al.

REPRODUCTIVE BIOLOGY (2020)

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Review Nutrition & Dietetics

Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

Pallavi Dubey et al.

NUTRIENTS (2020)

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Article Nutrition & Dietetics

Selenium Deficiency Is Associated with Mortality Risk from COVID-19

Arash Moghaddam et al.

NUTRIENTS (2020)

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Review Nutrition & Dietetics

Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19

Jan Alexander et al.

NUTRIENTS (2020)

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Review Nutrition & Dietetics

The Interaction between Dietary Selenium Intake and Genetics in Determining Cancer Risk and Outcome

Shrinidhi Kadkol et al.

NUTRIENTS (2020)

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Article Multidisciplinary Sciences

Association between Serum Essential Metal Elements and the Risk of Schizophrenia in China

Jiahui Ma et al.

SCIENTIFIC REPORTS (2020)

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Article Biochemistry & Molecular Biology

Supplemental selenium and coenzyme Q10 reduce glycation along with cardiovascular mortality in an elderly population with low selenium status - A four-year, prospective, randomised, double-blind placebo-controlled trial

Urban Alehagen et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Low selenium levels are associated with decreased bone mineral densities

Kyung-Chae Park et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2020)

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Article Medicine, General & Internal

Sex and gender: modifiers of health, disease, and medicine

Franck Mauvais-Jarvis et al.

LANCET (2020)

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Selenium supplementation in the prevention of coronavirus infections (COVID-19)

Marek Kieliszek et al.

MEDICAL HYPOTHESES (2020)

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Article Agriculture, Dairy & Animal Science

Selenium relieves oxidative stress, inflammation, and apoptosis within spleen of chicken exposed to mercuric chloride

Rui-Feng Fan et al.

POULTRY SCIENCE (2020)

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Review Nutrition & Dietetics

The Relevance of Selenium Status in Rheumatoid Arthritis

Francisco Javier Turrubiates-Hernandez et al.

NUTRIENTS (2020)

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Review Nutrition & Dietetics

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

Maria G. Grammatikopoulou et al.

NUTRIENTS (2020)

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Article Multidisciplinary Sciences

Thyroxine binding to type III iodothyronine deiodinase

Craig A. Bayse et al.

SCIENTIFIC REPORTS (2020)

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Review Biochemistry & Molecular Biology

Selenium and selenoproteins in viral infection with potential relevance to COVID-19

Jinsong Zhang et al.

REDOX BIOLOGY (2020)

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Review Nutrition & Dietetics

Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese Patients

Emre Sahin et al.

FRONTIERS IN NUTRITION (2020)

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Review Nutrition & Dietetics

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

Laurent Hiffler et al.

FRONTIERS IN NUTRITION (2020)

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Article Endocrinology & Metabolism

The Association of Circulating Selenium Concentrations with Diabetes Mellitus

Xiao-Long Liao et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

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Review Biochemistry & Molecular Biology

Looking Back at the Early Stages of Redox Biology

Leopold Flohe

ANTIOXIDANTS (2020)

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Article Psychiatry

Risk factors for depression. New evidence on selenium deficiency and depressive disorders

Krzysztof Czaderny

PSYCHIATRIA POLSKA (2020)

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Article Biochemistry & Molecular Biology

Selenoprotein V protects against endoplasmic reticulum stress and oxidative injury induced by pro-oxidants

Xu Zhang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Article Geriatrics & Gerontology

COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile

Sadanand Fulzele et al.

AGING AND DISEASE (2020)

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Article Chemistry, Multidisciplinary

Selenolesterase enzyme activity of carbonic anhydrases

Andrea Angeli et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Nutrition & Dietetics

Do patterns of nutrient intake predict self-reported anxiety, depression and psychological distress in adults? SEPAHAN study

Amin Salehi-Abargouei et al.

CLINICAL NUTRITION (2019)

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Article Biochemistry & Molecular Biology

Comparative Safety and Pharmacokinetic Evaluation of Three Oral Selenium Compounds in Cancer Patients

Stephen O. Evans et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Brain Selenium in Alzheimer's Disease (BRAIN SEAD Study): a Systematic Review and Meta-Analysis

Seshadri Reddy Varikasuvu et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2019)

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Article Clinical Neurology

Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease

Barbara R. Cardoso et al.

NEUROTHERAPEUTICS (2019)

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Article Biochemistry & Molecular Biology

Dietary antioxidant intake decreases carotid intima media thickness in women but not in men: A cross-sectional assessment in the Kardiovize study

Andrea Maugeri et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Psychiatry

A multifunctional compound ebselen reverses memory impairment, apoptosis and oxidative stress in a mouse model of sporadic Alzheimer's disease

Franciele Martini et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Selenium and selenium species in the etiology of Alzheimer's dementia: The potential for bias of the case-control study design

Marco Vinceti et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators

Damiano Tanini et al.

BIOORGANIC CHEMISTRY (2019)

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Review Cell Biology

Prioritized brain selenium retention and selenoprotein expression: Nutritional insights into Parkinson's disease

Xiong Zhang et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2019)

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Article Nutrition & Dietetics

Dietary Intake of Selenium in Relation to Pubertal Development in Mexican Children

Yun Liu et al.

NUTRIENTS (2019)

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Article Neurosciences

Oxidative stress and Parkinson's disease: conflict of oxidant-antioxidant systems

Mohsen Hemmati-Dinarvand et al.

NEUROSCIENCE LETTERS (2019)

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Article Cell Biology

H2S Protects against Cardiac Cell Hypertrophy through Regulation of Selenoproteins

Adam Greasley et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Endocrinology & Metabolism

Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyroiditis

F. Karimi et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2019)

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Article Cell Biology

Products of Sulfide/Selenite Interaction Possess Antioxidant Properties, Scavenge Superoxide-Derived Radicals, React with DNA, and Modulate Blood Pressure and Tension of Isolated Thoracic Aorta

Marian Grman et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Nutrition & Dietetics

Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer's disease: A randomized, double-blind, controlled trial

Omid Reza Tamtaji et al.

CLINICAL NUTRITION (2019)

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Article Endocrinology & Metabolism

Effect of selenium supplementation on changes in HbA1c: Results from a multiple-dose, randomized controlled trial

Saverio Stranges et al.

DIABETES OBESITY & METABOLISM (2019)

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Article Orthopedics

Association between dietary selenium intake and the prevalence of osteoporosis: a cross-sectional study

Yuqing Wang et al.

BMC MUSCULOSKELETAL DISORDERS (2019)

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Article Pharmacology & Pharmacy

L-selenomethionine supplementation in children and adolescents with autoimmune thyroiditis: A randomized double-blind placebo-controlled clinical trial

Ioannis Kyrgios et al.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2019)

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Article Pharmacology & Pharmacy

Selenomethionine potentiates the impact of vitamin D on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis and low vitamin D status

Robert Krysiak et al.

PHARMACOLOGICAL REPORTS (2019)

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Article Neurosciences

The selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole reverses depressive-like behavior induced by acute restraint stress in mice: modulation of oxido-nitrosative stress and inflammatory pathway

Angela Maria Casaril et al.

PSYCHOPHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes

Holger Steinbrenner et al.

REDOX BIOLOGY (2019)

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Article Endocrinology & Metabolism

Selenium supplementation and insulin resistance in a randomized, clinical trial

Elizabeth Theresa Jacobs et al.

BMJ OPEN DIABETES RESEARCH & CARE (2019)

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Article Medicine, General & Internal

Selenium Level in Patients with Heart Failure versus Normal Individuals

Ahmad Mirdamadi et al.

INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE (2019)

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Article Chemistry, Multidisciplinary

Direct biocatalysed synthesis of first sulfur-, selenium- and tellurium- containing l-ascorbyl hybrid derivatives with radical trapping and GPx-like properties

Damiano Tanini et al.

CHEMICAL COMMUNICATIONS (2019)

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Review Critical Care Medicine

Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?

Mathun Kuganesan et al.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2019)

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Article Endocrinology & Metabolism

Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studies

Juno Kim et al.

DIABETES & METABOLISM JOURNAL (2019)

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Review Food Science & Technology

Trace minerals intake: Risks and benefits for cardiovascular health

Noushin Mohammadifard et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

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Article Biochemistry & Molecular Biology

Endogenous Hydrogen Sulfide Promotes Apoptosis via Mitochondrial Pathways in the Livers of Broilers with Selenium Deficiency Exudative Diathesis Disease

Shu-fang Zheng et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2018)

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Review Public, Environmental & Occupational Health

Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis

Marco Vinceti et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2018)

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Article Food Science & Technology

Diet composition and serum levels of selenium species: A cross-sectional study

Tommaso Filippini et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

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Review Biochemistry & Molecular Biology

Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment

Valentina Gandin et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium

Rayudu Gopalakrishna et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Roles of mammalian glutathione peroxidase and thioredoxin reductase enzymes in the cellular response to nitrosative stress

Moran Benhar

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Review Biochemistry & Molecular Biology

SEXUAL DIMORPHISM IN SELENIUM METABOLISM AND SELENOPROTEINS

Lucia A. Seale et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic

Xiaoyuan Ren et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease

Sarah P. Short et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Selenoproteins in colon cancer

Kristin M. Peters et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Beneficial and paradoxical roles of selenium at nutritional levels of intake in healthspan and longevity

Li Zhang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Selenoprotein H controls cell cycle progression and proliferation of human colorectal cancer cells

Martin Bertz et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Significance of the mitochondrial thioredoxin reductase in cancer cells: An update on role, targets and inhibitors

Valeria Scalcon et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Selenoprotein T is a key player in ER proteostasis, endocrine homeostasis and neuroprotection

Youssef Anouar et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases

Jia-Qiang Huang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Article Clinical Neurology

Association of total zinc, iron, copper and selenium intakes with depression in the US adults

Zongyao Li et al.

JOURNAL OF AFFECTIVE DISORDERS (2018)

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Article Multidisciplinary Sciences

Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly

Urban Alehagen et al.

PLOS ONE (2018)

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Review Nutrition & Dietetics

Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications

Jessica Wang et al.

NUTRIENTS (2018)

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Article Oncology

Phase I trial of selenium plus chemotherapy in gynecologic cancers

Mihae Song et al.

GYNECOLOGIC ONCOLOGY (2018)

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Review Biochemistry & Molecular Biology

Selenium-Binding Protein 1 in Human Health and Disease

Mostafa Elhodaky et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Medicine, Research & Experimental

ALOX12 gene polymorphisms and serum selenium status in elderly osteoporotic patients

Atiyeh Al-e-Ahmad et al.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2018)

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Review Nutrition & Dietetics

Selenium and Type 2 Diabetes: Systematic Review

Lindsay N. Kohler et al.

NUTRIENTS (2018)

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Article Biochemistry & Molecular Biology

Association of Elements with Schizophrenia and Intervention of Selenium Supplements

Zhe Li et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10A mechanism behind reduced cardiovascular mortality?

Urban Alehagen et al.

BIOFACTORS (2018)

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Article Biochemistry & Molecular Biology

Selenium-Rich Ricegrass Juice Improves Antioxidant Properties and Nitric Oxide Inhibition in Macrophage Cells

Rattanamanee Chomchan et al.

ANTIOXIDANTS (2018)

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Article Biochemistry & Molecular Biology

Role of Hydrogen Sulfide on Autophagy in Liver Injuries Induced by Selenium Deficiency in Chickens

Wang Wenzhong et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2017)

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Article Food Science & Technology

Levels of plasma selenium and urinary total arsenic interact to affect the risk for prostate cancer

Yu-Mei Hsueh et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

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Article Neurosciences

Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL)

Barbara R. Cardoso et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Review Biochemistry & Molecular Biology

The effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of randomized controlled trials

W. Ju et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2017)

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Article Multidisciplinary Sciences

Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

Urban Alehagen et al.

PLOS ONE (2017)

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Article Nutrition & Dietetics

Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials

X. Zhang et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2016)

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Article Nutrition & Dietetics

Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial

Barbara Rita Cardoso et al.

EUROPEAN JOURNAL OF NUTRITION (2016)

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Review Biochemistry & Molecular Biology

Why Nature Chose Selenium

Hans J. Reich et al.

ACS CHEMICAL BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Effects of Dietary Selenium on Inflammation and Hydrogen Sulfide in the Gastrointestinal Tract in Chickens

Cong Wu et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Timothy R. Sampson et al.

CELL (2016)

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Article Multidisciplinary Sciences

Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men

Carolien M. Beukhof et al.

PLOS ONE (2016)

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Article Multidisciplinary Sciences

Supplementation with Selenium and Coenzyme Q10 Reduces Cardiovascular Mortality in Elderly with Low Selenium Status. A Secondary Analysis of a Randomised Clinical Trial

Urban Alehagen et al.

PLOS ONE (2016)

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Review Oncology

Selenium and Human Health: Witnessing a Copernican Revolution?

Ewa Jablonska et al.

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS (2015)

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Article Biochemistry & Molecular Biology

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases - A clinician's point of view

Urban Alehagen et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2015)

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Article Nutrition & Dietetics

Selenium reduces bradykinesia and DNA damage in a rat model of Parkinson's disease

Joel Henrique Ellwanger et al.

NUTRITION (2015)

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Review Nutrition & Dietetics

Selenium and Its Supplementation in Cardiovascular Disease-What do We Know?

Carina Benstoem et al.

NUTRIENTS (2015)

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Article Oncology

Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort

David J. Hughes et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

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Article Multidisciplinary Sciences

Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens

Urban Alehagen et al.

PLOS ONE (2015)

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Article Neurosciences

Increased Selenoprotein P in Choroid Plexus and Cerebrospinal Fluid in Alzheimer's Disease Brain

Rachel H. L. H. Rueli et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

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Review Pharmacology & Pharmacy

Selenium Cytotoxicity in Cancer

Marita Wallenberg et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2014)

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Review Neurosciences

Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson's Disease

Georgia S. Gaki et al.

NEUROMOLECULAR MEDICINE (2014)

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Review Physiology

SELENOPROTEINS: MOLECULAR PATHWAYS AND PHYSIOLOGICAL ROLES

Vyacheslav M. Labunskyy et al.

PHYSIOLOGICAL REVIEWS (2014)

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Review Anatomy & Morphology

Alpha-synuclein spreading in Parkinson's disease

Ariadna Recasens et al.

FRONTIERS IN NEUROANATOMY (2014)

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Article Nutrition & Dietetics

Selenium Fortification of an Italian Rice Cultivar via Foliar Fertilization with Sodium Selenate and Its Effects on Human Serum Selenium Levels and on Erythrocyte Glutathione Peroxidase Activity

Attilio Giacosa et al.

NUTRIENTS (2014)

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Article Medicine, General & Internal

Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic, Antiretroviral-Naive, HIV-Infected Adults in Botswana A Randomized Clinical Trial

Marianna K. Baum et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

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Review Medicine, General & Internal

Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy

Sally M. Reid et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2013)

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Article Geriatrics & Gerontology

THE PROTECTIVE EFFECT OF CALCIUM ON BONE MASS IN POSTMENOPAUSAL WOMEN WITH HIGH SELENIUM INTAKE

J. D. Pedrera-Zamorano et al.

JOURNAL OF NUTRITION HEALTH & AGING (2012)

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Review Medicine, General & Internal

Selenium and human health

Margaret P. Rayman

LANCET (2012)

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Article Biochemistry & Molecular Biology

Increased Oxidative Damage and Decreased Antioxidant Function in Aging Human Substantia Nigra Compared to Striatum: Implications for Parkinson's Disease

C. Venkateshappa et al.

NEUROCHEMICAL RESEARCH (2012)

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Article Nutrition & Dietetics

French adults' cognitive performance after daily supplementation with antioxidant vitamins and minerals at nutritional doses: a post hoc analysis of the Supplementation in Vitamins and Mineral Antioxidants (SU.VI.MAX) trial

Emmanuelle Kesse-Guyot et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2011)

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Article Medicine, General & Internal

Effect of Supplementation With High-Selenium Yeast on Plasma Lipids A Randomized Trial

Margaret P. Rayman et al.

ANNALS OF INTERNAL MEDICINE (2011)

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Article Biochemistry & Molecular Biology

Plasma Selenium, Zinc, Copper and Lipid Levels in Postmenopausal Turkish Women and Their Relation with Osteoporosis

Deniz Cemgil Arikan et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2011)

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Article Oncology

Serum Selenium, Genetic Variation in Selenoenzymes, and Risk of Colorectal Cancer: Primary Analysis from the Women's Health Initiative Observational Study and Meta-analysis

Yumie Takata et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2011)

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Article Endocrinology & Metabolism

Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency

Lone Banke Rasmussen et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2011)

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Review Neurosciences

Selenium and Alzheimer's Disease: A Systematic Review

Martin Loef et al.

JOURNAL OF ALZHEIMERS DISEASE (2011)

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Review Nutrition & Dietetics

High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism

Holger Steinbrenner et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2011)

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Article Endocrinology & Metabolism

Serum Selenoprotein P Levels in Patients with Type 2 Diabetes and Prediabetes: Implications for Insulin Resistance, Inflammation, and Atherosclerosis

S. J. Yang et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

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Article Food Science & Technology

Dietary selenium intake influences Cx43 dephosphorylation, TNF-α expression and cardiac remodeling after reperfused infarction

Stephane Tanguy et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2011)

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Article Medicine, Research & Experimental

Effect of selenium supplementation on CD4 T-cell recovery, viral suppression, morbidity and quality of life of HIV-infected patients in Rwanda: study protocol for a randomized controlled trial

Julius Kamwesiga et al.

TRIALS (2011)

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Review Biochemistry & Molecular Biology

Structure-Function Relations, Physiological Roles, and Evolution of Mammalian ER-Resident Selenoproteins

Valentina A. Shchedrina et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

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Article Biochemistry & Molecular Biology

The Neuroprotective Functions of Selenoprotein M and its Role in Cytosolic Calcium Regulation

Mariclair A. Reeves et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

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Article Oncology

Selenium and Bladder Cancer Risk: a Meta-analysis

Andre F. S. Amaral et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2010)

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Article Cell Biology

A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

Hirofumi Misu et al.

CELL METABOLISM (2010)

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Article Biochemistry & Molecular Biology

Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib

Dhimant Desai et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2010)

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Article Chemistry, Multidisciplinary

Selenium- and Tellurium-Containing Multifunctional Redox Agents as Biochemical Redox Modulators with Selective Cytotoxicity

Vincent Jamier et al.

CHEMISTRY-A EUROPEAN JOURNAL (2010)

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Review Urology & Nephrology

Update on chemoprevention for prostate cancer

Seth A. Strope et al.

CURRENT OPINION IN UROLOGY (2010)

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Article Oncology

Incidence of cancers, ischemic cardiovascular diseases and mortality during 5-year follow-up after stopping antioxidant vitamins and minerals supplements: a postintervention follow-up in the SU.VI.MAX Study

Serge Hercberg et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

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Review Endocrinology & Metabolism

Selenium and the Thyroid: A Close-Knit Connection

Leonidas H. Duntas

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)

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Article Medicine, Research & Experimental

Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

Erik Schoenmakers et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

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Article Clinical Neurology

Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model

Niall M. Corcoran et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2010)

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Article Clinical Neurology

Plasma Selenium is Positively Related to Performance in Neurological Tasks Assessing Coordination and Motor Speed

Avner Shahar et al.

MOVEMENT DISORDERS (2010)

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Article Neurosciences

Evaluation of antioxidant enzymes activities and lipid peroxidation in schizophrenic patients treated with typical and atypical antipsychotics

Manuela Padurariu et al.

NEUROSCIENCE LETTERS (2010)

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Article Multidisciplinary Sciences

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

Janet van Eersel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Review Endocrinology & Metabolism

Selenium Supplementation in the Treatment of Hashimoto's Thyroiditis: A Systematic Review and a Meta-analysis

Konstantinos A. Toulis et al.

THYROID (2010)

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Article Public, Environmental & Occupational Health

Serum Selenium and Peripheral Arterial Disease: Results From the National Health and Nutrition Examination Survey, 2003-2004

Joachim Bleys et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2009)

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Article Pathology

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

Jeroen J. M. Hoozemans et al.

AMERICAN JOURNAL OF PATHOLOGY (2009)

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Review Biochemistry & Molecular Biology

Regulation and function of selenoproteins in human disease

Frederick P. Bellinger et al.

BIOCHEMICAL JOURNAL (2009)

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Review Biochemistry & Molecular Biology

Selenoprotein P-Expression, functions, and roles in mammals

Raymond F. Burk et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

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Article Cell Biology

Reactive Oxygen Species Enhance Insulin Sensitivity

Kim Loh et al.

CELL METABOLISM (2009)

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Article Geriatrics & Gerontology

Concentrations of Metals, beta-Amyloid and Tau-Markers in Cerebrospinal Fluid in Patients with Alzheimer's Disease

Lars Gerhardsson et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2009)

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Review Clinical Neurology

Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein

Masahiro Kawahara et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2009)

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Article Biochemistry & Molecular Biology

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

Manuela Schneider et al.

FASEB JOURNAL (2009)

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Article Medicine, General & Internal

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial ( SELECT)

Scott M. Lippman et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2009)

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Article Andrology

Selenium Supplementation Does Not Affect Testicular Selenium Status or Semen Quality in North American Men

Wayne Chris Hawkes et al.

JOURNAL OF ANDROLOGY (2009)

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Article Biochemistry & Molecular Biology

Depletion of Selenoprotein GPx4 in Spermatocytes Causes Male Infertility in Mice

Hirotaka Imai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Article Oncology

Total and Cancer Mortality After Supplementation With Vitamins and Minerals: Follow-up of the Linxian General Population Nutrition Intervention Trial

You-Lin Qiao et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2009)

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Review Neurosciences

Calcium dysregulation in Alzheimer's disease: From mechanisms to therapeutic opportunities

Jin-Tai Yu et al.

PROGRESS IN NEUROBIOLOGY (2009)

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Article Endocrinology & Metabolism

Selenium Supplementation Fails to Correct the Selenoprotein Synthesis Defect in Subjects with Sequence Binding Protein 2 Gene Mutations

Lutz Schomburg et al.

THYROID (2009)

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Article Nutrition & Dietetics

Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and child outcomes

Roland Kupka et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2008)

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Article Medicine, General & Internal

Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults

Joachim Bleys et al.

ARCHIVES OF INTERNAL MEDICINE (2008)

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Article Biochemistry & Molecular Biology

Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice

Kostja Renko et al.

BIOCHEMICAL JOURNAL (2008)

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Article Nutrition & Dietetics

Both inorganic and organic selenium supplements can decrease brain monoamine oxidase B enzyme activity in adult rats

Ya-Li Tang et al.

BRITISH JOURNAL OF NUTRITION (2008)

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Article Endocrinology & Metabolism

Selenium and anticarcinogenesis: underlying mechanisms

Matthew I. Jackson et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2008)

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Review Biochemistry & Molecular Biology

Selenium intake and cardiovascular risk: what is new?

Ana Navas-Acien et al.

CURRENT OPINION IN LIPIDOLOGY (2008)

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Article Endocrinology & Metabolism

Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice

X. D. Wang et al.

DIABETOLOGIA (2008)

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Article Biochemistry & Molecular Biology

Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion

Luca Grumolato et al.

FASEB JOURNAL (2008)

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Article Biochemistry & Molecular Biology

Thioredoxin Reductase-1 Negatively Regulates HIV-1 Transactivating Protein Tat-dependent Transcription in Human Macrophages

Parisa Kalantari et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Neurosciences

ER stress is involved in Aβ-induced GSK-3β activation and tau phosphorylation

Rosa Resende et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2008)

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Article Multidisciplinary Sciences

Impaired glutathione synthesis in schizophrenia:: Convergent genetic and functional evidence

Rene Gysin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Biochemistry & Molecular Biology

Effect of age on sexually dimorphic selenoprotein expression in mice

Lutz Schomburg et al.

BIOLOGICAL CHEMISTRY (2007)

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Review Biochemistry & Molecular Biology

Selenium in mammalian spermiogenesis

Leopold Flohe

BIOLOGICAL CHEMISTRY (2007)

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Article Anesthesiology

Time course and relationship between plasma selenium concentrations, systemic inflammatory response, sepsis, and multiorgan failure

Y. Sakr et al.

BRITISH JOURNAL OF ANAESTHESIA (2007)

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Review Immunology

Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction

Xinwen Wang et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2007)

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Article Public, Environmental & Occupational Health

Selenium level and cognitive function in rural elderly Chinese

Sujuan Gao et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2007)

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Article Cardiac & Cardiovascular Systems

Blood pressure and blood selenium: a cross-sectional and longitudinal population study

Tim S. Nawrot et al.

EUROPEAN HEART JOURNAL (2007)

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Article Medicine, General & Internal

Suppression of human immunodeficiency virus type 1 viral load with selenium supplementation - A randomized controlled trial

Barry E. Hurwitz et al.

ARCHIVES OF INTERNAL MEDICINE (2007)

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Article Critical Care Medicine

Selenium in Intensive Care (SIC):: Results of a prospective. randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock

Matthias W. A. Angstwurm et al.

CRITICAL CARE MEDICINE (2007)

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Article Endocrinology & Metabolism

Selenium-dependent pre- and posttranscriptional mechanisms are responsible for sexual dimorphic expression of selenoproteins in murine tissues

Cornelia Riese et al.

ENDOCRINOLOGY (2006)

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Article Nutrition & Dietetics

Selenium and coronary heart disease: a meta-analysis

Gemma Flores-Mateo et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2006)

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Article Geriatrics & Gerontology

Lower plasma vitamin e levels are associated with the frailty syndrome: The InCHIANTI study

A Ble et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2006)

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Article Biotechnology & Applied Microbiology

Altered glutathione redox state in schizophrenia

Jeffrey K. Yao et al.

DISEASE MARKERS (2006)

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Article Genetics & Heredity

Mutations in SECISBP2 result in abnormal thyroid hormone metabolism

AM Dumitrescu et al.

NATURE GENETICS (2005)

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Article Oncology

Toenail selenium concentrations and bladder cancer risk in women and men

DS Michaud et al.

BRITISH JOURNAL OF CANCER (2005)

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Article Oncology

Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial

F Meyer et al.

INTERNATIONAL JOURNAL OF CANCER (2005)

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Article Biochemistry & Molecular Biology

Mammalian selenoprotein thioredoxin-glutathione reductase - Roles in disulfide bond formation and sperm maturation

D Su et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Article Nutrition & Dietetics

Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?

P Galan et al.

BRITISH JOURNAL OF NUTRITION (2005)

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Article Biochemistry & Molecular Biology

Alterations of the lipid profile after 7.5 years of low-dose antioxidant supplementation in the SU.VI.MAX study

S Hercberg et al.

LIPIDS (2005)

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Article Biochemistry & Molecular Biology

Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase

J Ghosh

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

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Article Biochemistry & Molecular Biology

The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction

K Mahadev et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

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Article Oncology

Effects of a high-selenium yeast supplement on celecoxib plasma levels: A randomized Phase II trial

DH Frank et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2004)

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Article Biotechnology & Applied Microbiology

Making sense of sex and supplements: differences in the anticarcinogenic effects of selenium in men and women

DJ Waters et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2004)

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Review Chemistry, Multidisciplinary

Organoselenium and organotellurium compounds: Toxicology and pharmacology

CW Nogueira et al.

CHEMICAL REVIEWS (2004)

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Article Medicine, General & Internal

The SU.VI.MAX study -: A randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals

S Hercberg et al.

ARCHIVES OF INTERNAL MEDICINE (2004)

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Article Multidisciplinary Sciences

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

L Zecca et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Multidisciplinary Sciences

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase

JP McClung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Nutrition & Dietetics

Selenium status is associated with accelerated HIV disease progression among HIV-1-infected pregnant women in Tanzania

R Kupka et al.

JOURNAL OF NUTRITION (2004)

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Article Immunology

Oxidant stress is increased during treatment of human immunodeficiency virus infection

T Hulgan et al.

CLINICAL INFECTIOUS DISEASES (2003)

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Article Pharmacology & Pharmacy

Induction of the mitochondrial permeability transition by selenium compounds mediated by oxidation of the protein thiol groups and generation of the superoxide

TS Kim et al.

BIOCHEMICAL PHARMACOLOGY (2003)

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Article Multidisciplinary Sciences

Active sites of thioredoxin reductases:: Why selenoproteins?

S Gromer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Review Biochemistry & Molecular Biology

Selenium-dependent enzymes in endothelial cell function

R Brigelius-Flohé et al.

ANTIOXIDANTS & REDOX SIGNALING (2003)

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Article Endocrinology & Metabolism

Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis

LH Duntas et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2003)

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Article Biochemistry & Molecular Biology

Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues

L Schomburg et al.

BIOCHEMICAL JOURNAL (2003)

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Article Endocrinology & Metabolism

Association of selenium with thyroid volume and echostructure in 35-to 60-year-old French adults

H Derumeaux et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2003)

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Article Biochemistry & Molecular Biology

Characterization of selenoprotein P as a selenium supply protein

Y Saito et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)

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Article Reproductive Biology

Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase

C Foresta et al.

BIOLOGY OF REPRODUCTION (2002)

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Article Biochemistry & Molecular Biology

Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages:: role of nuclear factor-κB in up-regulation

KS Prabhu et al.

BIOCHEMICAL JOURNAL (2002)

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Article Biochemistry & Molecular Biology

Protection of mice from allergen-induced asthma by selenite -: prevention of eosinophil infiltration by inhibition of NF-κB activation

DW Jeong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Biochemistry & Molecular Biology

Redox regulation of cytosolic glycerol-3-phosphate dehydrogenase:: Cys102 is the target of the redox control and essential for the catalytic activity

JY Kim et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2002)

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Review Biochemistry & Molecular Biology

Evidence of oxidative damage in Alzheimer's disease brain:: central role for amyloid β-peptide

DA Butterfield et al.

TRENDS IN MOLECULAR MEDICINE (2001)

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Article Biochemistry & Molecular Biology

Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation

H Pfeifer et al.

FASEB JOURNAL (2001)

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Article Reproductive Biology

Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human infertile males

H Imai et al.

BIOLOGY OF REPRODUCTION (2001)

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Article Neurosciences

Low selenium diet induces tyrosine hydroxylase enzyme in nigrostriatal system of the rat

M Romero-Ramos et al.

MOLECULAR BRAIN RESEARCH (2000)

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Article Geriatrics & Gerontology

Cognitive decline is associated with systemic oxidative stress:: The EVA study

C Berr et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2000)

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Article Neurosciences

Schizophrenia:: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo

KQ Do et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2000)

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Article Multidisciplinary Sciences

Structure and mechanism of mammalian thioredoxin reductase:: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

LW Zhong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Article Biochemistry & Molecular Biology

Selenite negatively regulates caspase-3 through a redox mechanism

HS Park et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Biochemistry & Molecular Biology

Selenite inhibits the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through a thiol redox mechanism

HS Park et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Review Chemistry, Multidisciplinary

Synthetic organoselenium compounds as antioxidants: glutathione peroxidase activity

G Mugesh et al.

CHEMICAL SOCIETY REVIEWS (2000)

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The Role of Selenium in Pathologies: An Updated Review

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