期刊
PAKISTAN VETERINARY JOURNAL
卷 42, 期 1, 页码 107-111出版社
UNIV AGRICULTURE, FAC VETERINARY SCIENCE
DOI: 10.29261/pakvetj/2021.035
关键词
Cardiac toxicity; Caspase-3; Cisplatin; Lycopene; N acetylcysteine; Rats
资金
- Taif University Researchers Supporting Project, Taif University, Taif, Saudi Arabia [TURSP-2020/57]
Cisplatin induces cardiac toxicity in rats, but lycopene and N-acetylcysteine administration can mitigate the toxicity and apoptosis through their antioxidant properties.
Cisplatin (CP) is one of antineoplastic agents with a broad range of anticancer activities. This research investigated the possible protective effects of lycopene (LP) and N acetylcysteine (NAC) in rats against CP-induced cardiac toxicity. Seven groups of rats (n=7); control vehicle group was administered saline, LP (10 mg/kg, PO), NAC (150 mg/kg, PO), CP group (7.5 mg/kg, IP) on the 27th day of the experiment, LP-CP group, NAC-CP group, and LP-NAC-CP group. Following injection of CP, concentrations of cardiac biomarkers, lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase MB (CK-MB) were increased in serum of the treated groups. In addition, CP resulted in a significant increase in malondialdehyde (MDA), as well as significant decreases in glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in rats' heart tissues. CP resulted in changes in cardiac histopathology and increased caspase-3 expression in cardiac tissues. Administration of LP and/or NAC ameliorated cardiac toxicity and apoptosis induced by CP, through their antioxidant properties.
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