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Heterogeneity of type 2 innate lymphoid cells

NATURE REVIEWS IMMUNOLOGY (2022)

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Article Allergy

Increased circulating CRTH2(+)Tregs are associated with asthma control and exacerbation

Teerapol Chantveerawong et al.

Summary: The frequency of CRTH2(+)Tregs is higher in patients with asthma, especially allergic phenotype, compared to healthy controls, and shows a negative correlation with ACT scores and PEFR. CRTH2(+)Tregs increase during exacerbation and decrease after asthma control. In vitro investigations demonstrate that Tregs of allergic patients with asthma display Th2-biased character.

ALLERGY (2022)

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Article Immunology

Bilirubin represents a negative regulator of ILC2 in allergic airway inflammation

Juan He et al.

Summary: Bilirubin, an end product of heme catabolism, was shown to be a potent negative regulator of ILC2s, suppressing their responses to IL-33 and alleviating airway inflammation. Mechanistic studies revealed that bilirubin exerts its effects on ILC2s through downregulation of ERK phosphorylation and GATA3 expression. Clinical evidence suggested that newborns with hyperbilirubinemia exhibited lower levels of functional ILC2 and suppressed ERK signaling. These findings suggest that bilirubin may have therapeutic potential in the treatment of allergic airway inflammation.

MUCOSAL IMMUNOLOGY (2022)

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Article Immunology

Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity

Jingjing Zhang et al.

Summary: This study identifies neuropilin-1 (Nrp1) as a tissue-specific marker of lung-resident ILC2s, which enhances their function and type 2 immune response by upregulating IL-33 receptor ST2 expression. Inhibition of Nrp1 suppresses IL-5 and IL-13 production by ILC2s and protects mice from the development of pulmonary fibrosis.

NATURE IMMUNOLOGY (2022)

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Article Gastroenterology & Hepatology

The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma

Bernd Heinrich et al.

Summary: Our study shows that the cytokine milieu in liver cancer controls the composition of ILCs and the outcome of HCC. Specific cytokine changes can alter ILC composition in the tumor, induce plasticity, and modify ILC function.

GUT (2022)

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Article Allergy

Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis

Natalia Alkon et al.

Summary: This study investigates the phenotypic and molecular features of cutaneous innate lymphoid cells (ILCs) to better understand the biological role of these cells. The findings demonstrate the flexibility of the skin immune system, with ILCs in diseased skin expressing genes characteristic of different immune types. This suggests that the skin immune system can adjust its function to adapt to the environment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivity

Emily Howard et al.

Summary: The study identified a unique subset of ILC2s, known as ILC2(10)s, which actively produce IL-10 to suppress proinflammatory ILC2 functions through autocrine and paracrine signaling, resulting in reduced lung inflammation and airway hyperresponsiveness in vivo. Furthermore, the research highlights the metabolic dependency of ILC2(10)s on the glycolytic pathway for IL-10 production, contrasting with the conventional fatty acid oxidation pathway used for proinflammatory effector functions.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Cell Biology

Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing

Luca Mazzurana et al.

Summary: This study utilized single-cell RNA sequencing to uncover tissue-specific transcriptional profiles and heterogeneity of CD127(+) ILCs in four human tissues. It identified migratory properties, tissue-residency, activation, and modified metabolism characteristics of ILCs in different tissues. The study also revealed potential differentiation pathways from naive to mature ILC subsets, and unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells.

CELL RESEARCH (2021)

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Letter Immunology

Severe COVID-19 patients exhibit an ILC2 NKG2D+ population in their impaired ILC compartment

Alejandra Gomez-Cadena et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Immunology

Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response

Korneliusz Golebski et al.

Summary: IL-10(+) ILC2s play a crucial role in modulating grass-pollen allergy, attenuating Th responses, and maintaining epithelial cell integrity. Patients with grass-pollen allergy have lower levels of IL-10(+) KLRG1(+) ILC2s, but this ability to produce IL-10 is restored after immunotherapy treatment. The mechanisms underlying this involve modifications in retinol metabolic pathway, cytokine-cytokine receptor interaction, and JAK-STAT signaling pathways in the ILCs.

IMMUNITY (2021)

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Review Immunology

Searching for the Elusive Regulatory Innate Lymphoid Cell

Sinthuja Jegatheeswaran et al.

Summary: The complexity and diverse effector functions of the ILC family have been the focus of intense research. Regulatory ILC populations have been identified that limit inflammatory responses or recruit other immunosuppressive cells, challenging current definitions and classification of ILCs.

JOURNAL OF IMMUNOLOGY (2021)

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Review Immunology

Group 2 Innate Lymphoid Cells: Team Players in Regulating Asthma

Noe Rodriguez-Rodriguez et al.

Summary: Type 2 immunity serves to protect the host from infection while also contributing to tissue homeostasis, metabolism, and repair. However, excessive type 2 immune reactions may lead to allergy and asthma. ILC2s in the lungs respond rapidly to environmental cues, playing a crucial role in regulating the pathology of allergic asthma.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

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Article Immunology

Dichotomous metabolic networks govern human ILC2 proliferation and function

Laura Surace et al.

Summary: ILC2 metabolism in humans is not well studied, but research shows that ILC2 relies on different metabolic pathways to sustain proliferation and function, with glycolysis and amino acids playing important roles post-activation for IL-13 production.

NATURE IMMUNOLOGY (2021)

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Article Immunology

Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization

Johannes U. Mayer et al.

Summary: The study demonstrates that IL-13 secreted by dermal innate lymphoid cells plays a crucial role in promoting the differentiation of a CD11b(lo) type 2 dendritic cell subset in the skin of mice and humans, supporting the development of T(H)2 cells and inhibiting T(H)17 cells. This homeostatic IL-13 fosters a noninflammatory skin environment conducive to allergic sensitization.

NATURE IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma

Leonard B. Bacharier et al.

Summary: This study showed that among children aged 6 to 11 with uncontrolled moderate-to-severe asthma, those who received add-on dupilumab had fewer asthma exacerbations, better lung function and asthma control compared to those who received placebo.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Skin-resident innate lymphoid cells converge on a pathogenic effector state

Piotr Bielecki et al.

Summary: This study reveals that induction of psoriasis in mice by IL-23 or imiquimod leads to a reconfiguration of skin ILCs towards a pathogenic ILC3-like state. Skin ILCs exhibit a range and flexibility in their responses, indicating that immune activities primed in healthy tissues dynamically adapt to provocations and, left unchecked, drive pathological remodelling.

NATURE (2021)

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Article Oncology

Type 2 Innate Lymphoid Cells Protect against Colorectal Cancer Progression and Predict Improved Patient Survival

Qiutong Huang et al.

Summary: Colorectal cancer is the second leading cause of cancer-related deaths globally. The study shows that specialized type 2 innate lymphoid cells (ILC2) infiltrate colorectal tumors and their presence is associated with reduced tumor burden and improved overall survival. This highlights the potential of ILC2 as a new therapeutic approach to improve clinical outcomes in colorectal cancer.

CANCERS (2021)

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Article Immunology

Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases

Esmee K. van der Ploeg et al.

Summary: Human CD45RO(+) inflammatory ILC2s, identified as an analog of mouse iILC2s, are associated with severe type 2 inflammatory disease and therapy resistance. Activation of these ILC2s is tightly linked to epithelial alarmins, leading to their increase in inflamed mucosal tissue.

SCIENCE IMMUNOLOGY (2021)

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Article Immunology

CD5 Surface Expression Marks Intravascular Human Innate Lymphoid Cells That Have a Distinct Ontogeny and Migrate to the Lung

Arlisa Alisjahbana et al.

Summary: This study reveals the uniqueness of CD5(+) ILCs in anatomical localization and developmental origin compared to well-studied CD5(-) ILCs, suggesting that they may play distinct roles in immune defense.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Gastroenterology & Hepatology

Group-2 Innate Lymphoid Cells Promote HCC Progression Through CXCL2-Neutrophil-Induced Immunosuppression

Xingyuan Xu et al.

Summary: The study revealed that ILC2s were highly enriched in human HCC and significantly correlated with tumor recurrence, progression-free survival, and overall survival in patients. The HCC-associated ILC2s were identified as an immune regulatory cell type that promotes tumor development, suggesting potential new treatments for HCC by targeting these cells.

HEPATOLOGY (2021)

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Article Allergy

IL-10-producing innate lymphoid cells increased in patients with house dust mite allergic rhinitis following immunotherapy

Tadech Boonpiyathad et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Hematology

Third-party type 2 innate lymphoid cells prevent and treat GI tract GvHD

Danny W. Bruce et al.

Summary: Third-party ILC2 cells enhance the survival of allo-HSCT recipients, requiring at least four weekly infusions of ILC2 cells. Mechanistically, the function of ILC2 cells depends on their ability to express both IL-13 and amphiregulin. The activity of IL-13 relies more on the expression of the IL-13R on host bone marrow cells rather than donor cells.

BLOOD ADVANCES (2021)

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Article Multidisciplinary Sciences

PPAR? drives IL-33-dependent ILC2 pro-tumoral functions

Giuseppe Ercolano et al.

Summary: The expression of PPARγ in ILC2s sustains type-2 cytokines secretion and supports their pro-tumorigenic role in preclinical cancer models. Pharmacologic inhibition or genetic deletion of PPARγ in ILC2s significantly impair IL-33-induced Type-2 cytokine production and mitochondrial fitness.

NATURE COMMUNICATIONS (2021)

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Review Immunology

Role of ILC2 in Viral-Induced Lung Pathogenesis

Wendy Fonseca et al.

Summary: ILC2, a population of innate cells, plays key roles in lung immunity and is linked to chronic lung pathologies. Following respiratory viral infections, increased ILC2 levels may lead to detrimental effects such as chronic inflammation and alterations in lung structure.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Rhinovirus C Infection Induces Type 2 Innate Lymphoid Cell Expansion and Eosinophilic Airway Inflammation

Charu Rajput et al.

Summary: The study developed a mouse model showing that RV-C15 infection induces type 2 airway inflammation, leading to exacerbated eosinophilic inflammation compared to RV-A1B.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Critical Care Medicine

Pulmonary Innate Lymphoid Cell Responses during Rhinovirus-induced Asthma Exacerbations In Vivo A Clinical Trial

Jaideep Dhariwal et al.

Summary: The study found that after experimental rhinovirus challenge, ILC2 levels were significantly higher in patients with asthma compared to healthy subjects, as well as the ILC2:ILC1 ratio. ILC2 may play an important role in virus-induced asthma exacerbations.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Review Allergy

Strategies for choosing a biologic for your patient with allergy or asthma

Tara Saco et al.

Summary: Biologics play a significant role in the treatment of respiratory and allergic diseases, with multiple drugs already approved or in clinical development. These drugs can target multiple diseases simultaneously, but clinicians face challenges in selecting the most appropriate biologic for each patient.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer

Jeremy Goc et al.

Summary: Research shows that ILC3s play a protective role in cancer, and alterations in CRC may lead to dysfunctional adaptive immunity, tumor progression, and immunotherapy resistance.

CELL (2021)

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Article Cell Biology

Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual

Bo Shan et al.

Summary: This study identified a specific subpopulation of iWAT adipocyte precursor cells that uniquely respond to cold stimuli, coupling adrenergic signaling with immune cell activation to promote thermogenic beige adipocyte formation. Additionally, acute cold challenge induced transcriptomic changes in DPP4+ PDGFR beta+ adipocyte precursor cells, including induction of prothermogenic cytokine Il33 expression. The deletion of Il33 in PDGFR beta+ cells at the onset of cold exposure attenuated ILC2 accumulation and beige adipocyte accrual.

GENES & DEVELOPMENT (2021)

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Article Immunology

An in vitro platform supports generation of human innate lymphoid cells from CD34+ hematopoietic progenitors that recapitulate ex vivo identity

Daniela Carolina Hernandez et al.

Summary: This study developed a platform to generate human ILC lineages from CD34(+) hematopoietic progenitors, providing a valuable resource for clarifying ILC biology and differentiation. The generation of NK/ILC1s, ILC2s, and ILC3s in vitro was validated by protein expression, functional assays, and transcriptome analysis, reflecting the characteristics of their ex vivo counterparts.

IMMUNITY (2021)

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Article Immunology

Gut Microbiota Regulate Gut-Lung Axis Inflammatory Responses by Mediating ILC2 Compartmental Migration

Qinqin Pu et al.

Summary: The gut microbiota plays a vital role in regulating the migration of ILC2 cells through the gut-lung axis, influencing host defense against infection. The study shows that two types of ILC2 cells have distinct but crucial roles in host immunity.

JOURNAL OF IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit

Filipa Cardoso et al.

Summary: Signals from sympathetic neurons and immune cells regulate adipocytes and contribute to fat tissue biology. A neuro-mesenchymal unit via a brain-adipose circuit controls ILC2s in adipose tissue, affecting metabolism and obesity. This study identifies a complex interaction between neuronal and immune cells in the regulation of host metabolism and obesity.

NATURE (2021)

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Article Immunology

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot et al.

Summary: ILC2s play a critical role in melanoma immunity by producing cytokines that enhance antitumor responses. High infiltration of ILC2s in melanoma is associated with good clinical prognosis, but their antitumor functions may be restricted by programmed cell death protein-1.

NATURE IMMUNOLOGY (2021)

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Article Cell Biology

Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression

Jingjing Qi et al.

Summary: Innate lymphoid cells (ILCs) are tissue-resident lymphocytes without antigen-specific receptors, and their roles in cancer immunity and immunotherapy are still unclear. Studies have identified tumor-specific ILC subsets in colorectal cancer (CRC) patients, with SLAMF1 potentially serving as an anti-tumor biomarker.

CELL REPORTS MEDICINE (2021)

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Article Respiratory System

Neutralization of IL-33 modifies the type 2 and type 3 inflammatory signature of viral induced asthma exacerbation

Kristi J. Warren et al.

Summary: The study demonstrated that blocking IL-33 in RSV-induced asthma exacerbation significantly reduces allergic inflammation and alleviates asthma symptoms. Neutralizing IL-33 was shown to decrease the numbers of ILC2 and eosinophils, as well as reduce the expression of allergic proteins.

RESPIRATORY RESEARCH (2021)

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Article Immunology

ILC2s are the predominant source of intestinal ILC-derived IL-10

Jennifer K. Bando et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Allergy

Optimal identification of human conventional and nonconventional (CRTH2(-)IL7R alpha(-)) ILC2s using additional surface markers

Sucai Liu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Immunology

Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity

Roberto R. Ricardo-Gonzalez et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Immunology

The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung

Oyebola O. Oyesola et al.

JOURNAL OF IMMUNOLOGY (2020)

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Article Immunology

Uric acid pathway activation during respiratory virus infection promotes Th2 immune response via innate cytokine production and ILC2 accumulation

Wendy Fonseca et al.

MUCOSAL IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

John Alec Moral et al.

NATURE (2020)

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Article Immunology

Developmental plasticity allows outside-in immune responses by resident memory T cells

Raissa Fonseca et al.

NATURE IMMUNOLOGY (2020)

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Article Immunology

BATF acts as an essential regulator of IL-25-responsive migratory ILC2 cell fate and function

Mindy M. Miller et al.

SCIENCE IMMUNOLOGY (2020)

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Article Cell Biology

Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer

Shuo Wang et al.

CELL RESEARCH (2020)

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Article Immunology

Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA

Naoko Satoh-Takayama et al.

IMMUNITY (2020)

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Article Immunology

Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation

Fotios Karagiannis et al.

IMMUNITY (2020)

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Article Oncology

Mesenchymal PGD2 activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs

Limei Wu et al.

LEUKEMIA (2020)

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Article Immunology

ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure

Anja Schulz-Kuhnt et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung

Martijn J. Schuijs et al.

NATURE IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

IL-10 producing type 2 innate lymphoid cells prolong islet allograft survival

Qingsong Huang et al.

EMBO MOLECULAR MEDICINE (2020)

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Article Immunology

In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors

Patrice Zeis et al.

IMMUNITY (2020)

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Article Immunology

Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity

Benjamin P. Hurrell et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

PD-1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator-activated receptor-γ

Banu Batyrova et al.

IMMUNITY INFLAMMATION AND DISEASE (2020)

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Review Immunology

Plasticity of innate lymphoid cell subsets

Suzanne M. Bal et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Immunology

Innate lymphoid cell composition associates with COVID-19 disease severity

Marina Garcia et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

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Article Gastroenterology & Hepatology

Distinct Alterations in the Composition of Mucosal Innate Lymphoid Cells in Newly Diagnosed and Established Crohn's Disease and Ulcerative Colitis

Marianne Forkel et al.

JOURNAL OF CROHNS & COLITIS (2019)

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Article Immunology

Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells

Thomas Hochdorfer et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2019)

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Article Immunology

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life

Renee R. C. E. Schreurs et al.

IMMUNITY (2019)

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Article Allergy

Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid

Hideaki Morita et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Allergy

Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients

Carla Winkler et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

Lauriane Galle-Treger et al.

NATURE COMMUNICATIONS (2019)

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Article Immunology

Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming

Christoph Schneider et al.

IMMUNITY (2019)

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Article Critical Care Medicine

Elevated Levels of Type 2 Respiratory Innate Lymphoid Cells in Human Infants with Severe Respiratory Syncytial Virus Bronchiolitis

Luan D. Vu et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Article Immunology

Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation

Hiroyuki Nagashima et al.

IMMUNITY (2019)

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Article Immunology

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

Batika M. J. Rana et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Article Immunology

KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2- ILCs biased toward ILC2 or ILC3

Maho Nagasawa et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Article Immunology

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

Jochem H. Bernink et al.

NATURE IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

Korneliusz Golebski et al.

NATURE COMMUNICATIONS (2019)

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Article Immunology

Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans

Franz Puttur et al.

SCIENCE IMMUNOLOGY (2019)

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Article Immunology

Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses

Antonia Wallrapp et al.

IMMUNITY (2019)

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Article Immunology

ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites

Laura Campbell et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Article Allergy

Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation

Jovana Maric et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Immunology

Memory CD4+ T cells are generated in the human fetal intestine

Na Li et al.

NATURE IMMUNOLOGY (2019)

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Review Immunology

ILC2s: New Actors in Tumor Immunity

Giuseppe Ercolano et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling

Christoph Schneider et al.

CELL (2018)

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Article Allergy

Regulation of type 2 innate lymphoid cell-dependent airway hyperreactivity by butyrate

Christina Li-Ping Thio et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Immunology

Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2

Satoshi Koga et al.

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Article Multidisciplinary Sciences

S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

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SCIENCE (2018)

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Pulmonary neuroendocrine cells amplify allergic asthma responses

Pengfei Sui et al.

SCIENCE (2018)

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Jose Ordovas-Montanes et al.

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Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

Kairui Mao et al.

NATURE (2018)

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Article Immunology

Tissue signals imprint ILC2 identity with anticipatory function

Roberto R. Ricardo-Gonzalez et al.

NATURE IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

Antonia Wallrapp et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Alternative activation generates IL-10 producing type 2 innate lymphoid cells

Corey R. Seehus et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

Sara Trabanelli et al.

NATURE COMMUNICATIONS (2017)

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Article Microbiology

Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy

Benjamin Kraemer et al.

PLOS PATHOGENS (2017)

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Article Immunology

Human CD5+ Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34+ Progenitor Cells Is Regulated by Id2

Maho Nagasawa et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Critical Care Medicine

Allergen-induced Increases in Sputum Levels of Group 2 Innate Lymphoid Cells in Subjects with Asthma

Ruchong Chen et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

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Article Immunology

Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression

Henrik N. Kloverpris et al.

IMMUNITY (2016)

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Article Immunology

IL-12 drives functional plasticity of human group 2 innate lymphoid cells

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