期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 20, 期 14, 页码 2808-2812出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob00249c
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资金
- JSPS KAKENHI [JP21K14633, JP21K05061]
We developed a new catalytic system for the decarbonylative C(sp(2))-H alkylation of indolines. This method allows for the use of cheap, abundant, and non-toxic alkyl carboxylic acids and their anhydrides as an alkyl source, introducing a primary alkyl chain that was not possible with previous methods.
We developed a rhodium-catalysed decarbonylative C(sp(2))-H alkylation method for indolines. This reaction facilitates the use of alkyl carboxylic acids and their anhydrides as a cheap, abundant and non-toxic alkyl source under redox-neutral conditions, featuring the introduction of a primary alkyl chain, which cannot be addressed by previous radical-mediated decarboxylative reaction. Through a mechanistic investigation, we revealed that an initially formed C-7 acylated indoline was transformed into the corresponding alkylated indoline via a decarbonylation process.
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