期刊
NATURE METABOLISM
卷 4, 期 3, 页码 320-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s42255-022-00545-5
关键词
-
资金
- National Natural Science Foundation of China [31670417, 31870388, 92057206]
- [2019YFA0801900]
The study reveals that exposure to a temperature of 32.5 degrees C leads to a reduced lifespan in both mice and hamsters, coinciding with lowered metabolic rate and elevated body temperature. This demonstrates the significant impact of body temperature and metabolic rate on lifespan.
The relationships between metabolic rate, body temperature (T-b), body composition and ageing are complex, and not fully resolved. In particular, T-b and metabolic rate often change in parallel, making disentangling their effects difficult. Here we show that in both sexes of mice and hamsters exposure to a temperature of 32.5 degrees C leads to a reduced lifespan, coincident with lowered metabolic rate and elevated T-b with no change in body composition. We exploit the unique situation that when small mammals are exposed to hot ambient temperatures their T-b goes up, at the same time that their metabolic rate goes down, allowing us to experimentally separate the impacts of T-b and metabolic rate on lifespan. The impact of ambient temperature on lifespan can be reversed by exposing the animals to elevated heat loss by forced convection, which reverses the effect on T-b but does not affect metabolic rate, demonstrating the causal effect of T-b on lifespan under laboratory conditions for these models. The impact of manipulations such as calorie restriction that increase lifespan may be mediated via effects on T-b, and measuring T-b may be a useful screening tool for putative therapeutics to extend the human lifespan. Zhao et al. uncouple the effects of body temperature and metabolic rate on lifespan in two rodent models, showing that in warm conditions, where body temperature is elevated and metabolic rate reduced, lifespan is reduced. Reversal of increased body temperature reverses the negative impact of high ambient temperatures on lifespan despite lowered metabolic rate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据