Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands

Article Pathology

Sclerosing Polycystic Adenoma of Salivary Glands A Novel Neoplasm Characterized by PI3K-AKT Pathway Alterations-New Insights Into a Challenging Entity

Alena Skalova et al.

Summary: Sclerosing polycystic adenoma (SPA) is a rare salivary gland tumor that can develop intraluminal epithelial proliferation with different cytomorphologic characteristics, and it has specific molecular alterations.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2022)

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Article Pathology

The Myoepithelial Cells of Salivary Intercalated Duct-type Intraductal Carcinoma Are Neoplastic A Study Using Combined Whole-slide Imaging, Immunofluorescence, and RET Fluorescence In Situ Hybridization

Justin A. Bishop et al.

Summary: Intraductal carcinoma (IDC) of the salivary gland is similar to breast ductal carcinoma in situ and can be divided into at least 3 different types based on molecular insights. Recent studies have challenged the notion that myoepithelial cells in IDC are non-neoplastic, raising questions about the appropriate terminology and classification for this tumor.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2021)

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Article Pathology

Salivary Mucinous Adenocarcinoma Is a Histologically Diverse Single Entity With Recurrent AKT1 E17K Mutations Clinicopathologic and Molecular Characterization With Proposal for a Unified Classification

Lisa M. Rooper et al.

Summary: The clinicopathologic and molecular features of salivary mucinous adenocarcinomas were evaluated for classification clarification, revealing a histologically diverse single entity closely related to salivary intraductal papillary mucinous neoplasm. A unified mucinous adenocarcinoma category subdivided into papillary, colloid, signet ring, and mixed subtypes is proposed for better recognition and classification of these tumors, with recurrent AKT1 E17K mutations across patterns suggesting their close relationship.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2021)

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Review Pathology

High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance

Alena Skalova et al.

Summary: High-grade transformation in salivary gland carcinomas consists of traditional low-grade components intermingled with areas of high-grade morphology, with higher Ki-67 labeling index and potential genetic alterations like p53 inactivation and HER2 overexpression. These tumors are more aggressive than conventional carcinomas, with a higher recurrence rate and poorer prognosis, necessitating thorough sampling to avoid overlooking the high-grade component.

ADVANCES IN ANATOMIC PATHOLOGY (2021)

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Article Cell Biology

Oncocytic intraductal carcinoma of salivary glands: a distinct variant with TRIM33-RET fusions and BRAF V600E mutations

Justin A. Bishop et al.

Summary: Salivary gland intraductal carcinoma (IDC) is a complex ductal neoplasm with multiple subtypes, including oncocytic IDC which shares similarities with intercalated duct-like IDC. Molecular analysis is essential for distinguishing different IDC subtypes.

HISTOPATHOLOGY (2021)

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Article Pathology

Microsecretory Adenocarcinoma of Salivary Glands: An Expanded Series of 24 Cases

Justin A. Bishop et al.

Summary: Microsecretory adenocarcinoma (MSA) is a recently described salivary gland tumor with characteristic histologic and immunophenotypic features. Most cases of MSA occur in the oral cavity, with consistent clinical behavior following surgery. The study suggests that MSA is a distinct and low-grade salivary gland carcinoma that generally has a benign clinical course.

HEAD & NECK PATHOLOGY (2021)

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Article Pathology

SS18 Break-Apart Fluorescence In Situ Hybridization is a Practical and Effective Method for Diagnosing Microsecretory Adenocarcinoma of Salivary Glands

Justin A. Bishop et al.

Summary: Molecular analysis refines salivary gland tumor classification and identifies new tumor types. Microsecretory adenocarcinoma (MSA) is characterized by microcystic growth, bland cytomorphology, luminal secretions, and fibromyxoid stroma, defined by MEF2C-SS18 fusion. SS18 break-apart FISH is highly sensitive and specific for diagnosing MSA.

HEAD & NECK PATHOLOGY (2021)

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Article Pathology

Salivary Intraductal Carcinoma Arising within Intraparotid Lymph Node: A Report of 4 Cases with Identification of a NovelSTRN-ALKFusion

Lisa M. Rooper et al.

Summary: Intraductal carcinoma (IDC) is a rare salivary gland tumor that presents a complex epithelial proliferation with different subtypes. Recent cases of IDC arising within lymph nodes have sparked discussions on its classification and nature.

HEAD & NECK PATHOLOGY (2021)

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Article Cell Biology

Histopathological evaluation of minor salivary gland papillary-cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm

Masato Nakaguro et al.

HISTOPATHOLOGY (2020)

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Article Pathology

Histologic spectrum of polymorphous adenocarcinoma of the salivary gland harbor genetic alterations affecting PRKD genes

Ana Paula Martins Sebastiao et al.

MODERN PATHOLOGY (2020)

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Article Pathology

Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG) An International Interobserver Study

Bin Xu et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2020)

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Article Pathology

Molecular Profiling of Salivary Oncocytic Mucoepidermoid Carcinomas Helps to Resolve Differential Diagnostic Dilemma With Low-grade Oncocytic Lesions

Alena Skalova et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2020)

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Article Pathology

Sclerosing Polycystic Adenosis of Salivary Glands: A Neoplasm Characterized by PI3K Pathway Alterations More Correctly Named Sclerosing Polycystic Adenoma

Justin A. Bishop et al.

HEAD & NECK PATHOLOGY (2020)

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Review Immunology

An update on head and neck cancer: new entities and their histopathology, molecular background, treatment, and outcome

Simon Andreasen et al.

APMIS (2019)

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Article Pathology

Microsecretory Adenocarcinoma A Novel Salivary Gland Tumor Characterized by a Recurrent MEF2C-SS18 Fusion

Justin A. Bishop et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2019)

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Article Pathology

NCOA4-RET and TRIM27-RET Are Characteristic Gene Fusions in Salivary Intraductal Carcinoma, Including Invasive and Metastatic Tumors Is Intraductal Correct?

Alena Skalova et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2019)

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Letter Pathology

Intraductal Papillary Mucinous Neoplasm of the Minor Salivary Gland With Associated Invasive Micropapillary Carcinoma

Shaodong Yang et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2019)

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Article Medical Laboratory Technology

Data Set for the Reporting of Carcinomas of the Major Salivary Glands Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting

Raja R. Seethala et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2019)

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Letter Pathology

Microcystic Adenocarcinoma: An Initially Overlooked First Proposal of the Term

Fumio Ide et al.

HEAD & NECK PATHOLOGY (2019)

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Article Pathology

Recurrent RET Gene Rearrangements in Intraductal Carcinomas of Salivary Gland

Ilan Weinreb et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2018)

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Review Pathology

The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas

Alena Skalova et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2018)

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Article Pathology

Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation

Abbas Agaimy et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2018)

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Article Pathology

Molecular Profiling of Salivary Gland Intraductal Carcinoma Revealed a Subset of Tumors Harboring NCOA4-RET and Novel TRIM27-RET Fusions A Report of 17 cases

Alena Skalova et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2018)

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Article Oncology

The PRKD1 E710D hotspot mutation is highly specific in separating polymorphous adenocarcinoma of the palate from adenoid cystic carcinoma and pleomorphic adenoma on FNA

Simon Andreasen et al.

CANCER CYTOPATHOLOGY (2018)

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Article Pathology

Newly described salivary gland tumors

Alena Skalova et al.

MODERN PATHOLOGY (2017)

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Article Pathology

Striated duct adenoma presenting with intra-tumoral hematoma and papillary thyroid carcinoma-like histology

Yohei Ito et al.

PATHOLOGY INTERNATIONAL (2017)

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Article Pathology

Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma

Anne M. Mills et al.

HEAD & NECK PATHOLOGY (2016)

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Article Oncology

Novel PRKD Gene Rearrangements and Variant Fusions in Cribriform Adenocarcinoma of Salivary Gland Origin

Ilan Weinreb et al.

GENES CHROMOSOMES & CANCER (2014)

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Article Genetics & Heredity

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adeno carcinomas of the salivary glands

Ilan Weinreb et al.

NATURE GENETICS (2014)

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Article Pathology

Invasive carcinoma arising from sclerosing polycystic adenosis of the salivary gland

Rita Canas Marques et al.

VIRCHOWS ARCHIV (2014)

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Review Pathology

Salivary Duct Carcinoma: New Developments-Morphological Variants Including Pure In Situ High Grade Lesions; Proposed Molecular Classification

Roderick H. W. Simpson

HEAD & NECK PATHOLOGY (2013)

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Review Pathology

Oncocytic and Apocrine Epithelial Myoepithelial Carcinoma: Novel Variants of a Challenging Tumor

Raja R. Seethala

HEAD & NECK PATHOLOGY (2013)

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Review Pathology

Histologic Grading and Prognostic Biomarkers in Salivary Gland Carcinomas

Raja R. Seethala

ADVANCES IN ANATOMIC PATHOLOGY (2011)

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Article Pathology

Cribriform Adenocarcinoma of Minor Salivary Gland Origin Principally Affecting the Tongue: Characterization of New Entity

Alena Skalova et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2011)

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Letter Dentistry, Oral Surgery & Medicine

Microcystic adnexal (sclerosing sweat duct) carcinoma of intraoral minor salivary gland origin: an extracutaneous adnexal neoplasm?

Fumio Ide et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY (2011)

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Article Cell Biology

Ductal adenomas of salivary gland showing features of striated duct differentiation ('striated duct adenoma'): a report of six cases

Ilan Weinreb et al.

HISTOPATHOLOGY (2010)

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Article Pathology

Intercalated Duct Lesions of Salivary Gland A Morphologic Spectrum From Hyperplasia to Adenoma

Ilan Weinreb et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2009)

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Article Pathology

Low-grade intraductal carcinoma of salivary gland -: Report of 3 cases with marked apocrine differentiation

Ilan Weinreb et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2006)

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Article Pathology

Keratocystoma of the parotid gland: A report of two cases of an unusual pathologic entity

T Nagao et al.

MODERN PATHOLOGY (2002)

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Article Cell Biology

Intercalated duct hyperplasia: possible relationship to epithelial-myoepithelial carcinoma and hybrid tumours of salivary gland

R Chetty

HISTOPATHOLOGY (2000)

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Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands

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