Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles

A sustainable strategy for the alkylation of heterocycles is presented. The protocol relies on the in situ generation and further in-line use of alkyl zinc sulfinates through a continuous-flow system. The environmentally friendly character of the protocol is assured by the use of a green solvent mixture, the presence of a metal free oxidant and low waste generation.

Automated summary

A sustainable strategy for alkylation of heterocycles is proposed, which involves the in situ generation and further in-line use of alkyl zinc sulfinates through a continuous-flow system. The protocol demonstrates environmentally friendly characteristics by employing a green solvent mixture, a metal-free oxidant, and low waste generation.