期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 86, 期 5, 页码 646-654出版社
OXFORD UNIV PRESS
DOI: 10.1093/bbb/zbac028
关键词
atopic dermatitis; inflammation; rhodophyceae; skin barrier; filaggrin
类别
资金
- Ministry of Science and Technology of Taiwan [MOST 108-2313-B-110-001-MY3]
- Zuoying Branch of Kaohsiung Armed Forces General Hospital
This study demonstrated that the ethyl acetate fraction of S. suiae sp. extract has anti-inflammatory effects, alleviates symptoms of AD, inhibits inflammatory responses in skin tissues, and restores barrier function.
Atopic dermatitis (AD) is a chronic inflammatory and pruritic disease; it can be treated by inhibiting inflammation. Sarcodia suiae sp. is an edible, artificially cultivable red algae with multiple bioactivities. We assessed the anti-inflammatory activity of the ethyl acetate fraction of S. suiae sp. ethanol extract (PD1) on 1-chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions. Results show that PD1 alleviated symptoms and significantly decreased clinical dermatitis score. PD1 inhibited serum immunoglobulin E expression and alleviated swelling in the spleen and subiliac lymph nodes. In skin tissues, PD1 alleviated aberrant hyperplasia, decreased epidermal thickness, and decreased the accumulation of mast cells. PD1 mediated the recovery of skin barrier-related proteins, such as claudin-1 and filaggrin. Our study demonstrated that PD1 has anti-inflammatory effects, alleviates AD symptoms, inhibits inflammatory responses in skin tissues, and restores barrier function in DNCB-induced AD mice. These findings reveal that S. suiae sp. extract provides an alternative protective option against AD.
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