期刊
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
卷 55, 期 1, 页码 -出版社
ASSOC BRAS DIVULG CIENTIFICA
DOI: 10.1590/1414-431X2022e11832
关键词
Gut microbiota; Colorectal cancer; Faecalibacterium prausnitzii; Fusobacterium nucleatum; Dysbiosis
资金
- INCT (National Institute of Science and Technology for Diabetes and Obesity) [465693/2014-8CNPq]
- FAPESP [2014/50907-5]
This study investigated the composition of gut microbiota in Brazilian colorectal adenocarcinoma (CRC) patients compared with a control population. The results showed that CRC patients had increased alpha diversity, higher percentage of Prevotella genus, and decreased proportion of Megamonas and Ruminococcus. Faecalibacterium prausnitzii was associated with a better prognosis in early stages of CRC, while Fusobacterium nucleatum was identified as an important marker of colorectal carcinogenesis and tumor aggressiveness.
The human gut microbiota is a complex and dynamic community of microorganisms living in our intestines and has emerged as an important factor for colorectal adenocarcinoma (CRC). The purpose of our study was to investigate the microbiota composition in Brazilian CRC patients compared with a local control population (CTL) to find out which changes could be considered universal or regional features in CRC microbiota. Fecal samples were obtained from 28 CRC and 23 CTL individuals. The 16S rRNA gene was used for metagenomic analysis. In addition to the anthropometric variables, the clinical stage (TNM 2018) was considered. Patients with CRC had a significant increase in alpha diversity and a higher percentage of genus Prevotella and a decreased proportion of Megamonas and Ruminococcus. Additionally, the proportion of Faecalibacterium prausnitzii was associated with a better prognosis in the first stages of CRC, and Fusobacterium nucleatum proved to be an important marker of colorectal carcinogenesis and tumor aggressiveness. Although regional differences influence the composition of the microbiota, in the case of CRC, the microhabitat created by the tumor seems to be a major factor. Our results contribute to a better understanding of the carcinogenic process, and even in different environments, some factors appear to be characteristic of the microbiota of patients with CRC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据