Systemic Sclerosis (SSc) After COVID-19: A Case Report

Article Immunology

Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases

Aristo Vojdani et al.

Summary: The study found immune reactivity between SARS-CoV-2 antibodies and various human tissue antigens, as well as similarities between COVID-19 viral proteins and human tissue antigens. This extensive immune cross-reactivity may impact the disease progression of COVID-19, affecting disease severity, triggering autoimmunity, and exacerbating pre-existing autoimmune diseases. The results highlight potential risks for autoimmunity and multi-system disorders with COVID-19, emphasizing the importance of ensuring the safety of vaccines and treatments against this disease.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

The SARS-CoV-2 as an instrumental trigger of autoimmunity

Arad Dotan et al.

Summary: This article emphasizes the association between COVID-19 and the development of multiple types of autoantibodies and autoimmune diseases in patients. It highlights the potential molecular resemblance between SARS-CoV-2 and host self-components, leading to hyper-stimulation of the immune system. Recognizing autoimmune manifestations of COVID-19 is crucial for managing the ongoing pandemic and its long-term consequences.

AUTOIMMUNITY REVIEWS (2021)

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Review Immunology

Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review

Kuo-Tung Tang et al.

Summary: The systematic review highlights the potential of COVID-19 to trigger various autoimmune and rheumatic manifestations, including autoimmune cytopenia, cutaneous vasculitis, encephalitis, and Guillain-Barre syndrome. While certain associations like antiphospholipid syndrome, hemophagocytic lymphohistiocytosis, and myasthenia gravis remain conflicting.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Adaptive Immunity and the Risk of Autoreactivity in COVID-19

Rhiane Moody et al.

Summary: COVID-19, primarily a respiratory infection, can lead to complications affecting multiple organs. Immune responses can both protect against and exacerbate the disease. Viral infections have been linked to autoimmune diseases like multiple sclerosis and lupus, with reports of new onset autoimmune-like diseases in COVID-19 patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement

Mugdha Mohkhedkar et al.

Summary: The study identifies 28 human proteins with regions homologous to SARS-CoV-2 peptides as potential autoantigens, explaining the occurrence of autoimmune conditions following COVID-19 infection. These autoantigens are found to be distributed widely in tissues, suggesting their involvement in multi-organ manifestations through molecular mimicry. The report may guide future antigen-specific studies for management of extrapulmonary symptoms of COVID-19.

MOLECULAR IMMUNOLOGY (2021)

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Article Immunology

Case Report: Systemic Sclerosis After Covid-19 Infection

Serena Fineschi

Summary: COVID-19 infection can trigger autoimmune diseases like systemic sclerosis (SSc) and lead to the production of autoantibodies. This case report describes a patient who developed autoantibody production and symptoms affecting the skin and gastrointestinal system after mild COVID-19 infection, eventually being diagnosed with SSc.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy